| Identification |
|---|
| HMDB Protein ID
| CDBP00635 |
| Secondary Accession Numbers
| Not Available |
| Name
| L-serine dehydratase/L-threonine deaminase |
| Description
| Not Available |
| Synonyms
|
- L-serine deaminase
- L-threonine dehydratase
- SDH
- TDH
|
| Gene Name
| SDS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| L-serine catabolic process |
| gluconeogenesis |
| pyruvate biosynthetic process |
| Cellular Component |
| mitochondrion |
| Function |
| binding |
| catalytic activity |
| cofactor binding |
| pyridoxal phosphate binding |
| Molecular Function |
| L-threonine ammonia-lyase activity |
| pyridoxal phosphate binding |
| protein homodimerization activity |
| L-serine ammonia-lyase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycine, serine and threonine metabolism | Not Available |  | | Cysteine and methionine metabolism | Not Available |  | | Ammonia Recycling |    |  | | Threonine and 2-Oxobutanoate Degradation |    | Not Available | | Glycine and Serine Metabolism |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q24.13 |
| SNPs
| SDS |
| Gene Sequence
|
>987 bp
ATGATGTCTGGAGAACCCCTGCACGTGAAGACCCCCATCCGTGACAGCATGGCCCTGTCC
AAAATGGCCGGCACCAGCGTCTACCTCAAGATGGACAGTGCCCAGCCCTCCGGCTCCTTC
AAGATCCGGGGCATTGGGCACTTCTGCAAGAGGTGGGCCAAGCAAGGCTGTGCACATTTT
GTCTGCTCCTCGGCGGGCAACGCAGGCATGGCGGCTGCATATGCGGCCAGGCAACTCGGC
GTCCCCGCCACCATCGTGGTGCCCAGCACCACACCTGCTCTCACCATTGAGCGCCTCAAG
AATGAAGGTGCCACAGTCAAGGTGGTGGGTGAGTTATTGGATGAAGCCTTCGAGCTGGCC
AAGGCCCTAGCGAAGAACAACCCGGGTTGGGTCTACATTCCCCCCTTTGATGACCCCCTC
ATCTGGGAAGGCCACGCTTCCATCGTGAAAGAGCTGAAGGAGACACTGTGGGAAAAGCCG
GGGGCCATCGCGCTGTCAGTGGGCGGCGGGGGCCTGCTGTGTGGAGTGGTCCAGGGGCTG
CAGGAGGTGGGCTGGGGGGACGTGCCTGTCATCGCCATGGAGACTTTTGGTGCCCACAGC
TTCCACGCTGCCACCACCGCAGGCAAACTTGTCTCCCTGCCCAAGATCACCAGTGTTGCC
AAGGCCCTGGGCGTGAAGACTGTGGGGGCTCAGGCCCTGAAGCTGTTTCAGGAACACCCC
ATTTTCTCTGAAGTTATCTCGGACCAGGAGGCTGTGGCCGCCATTGAGAAGTTCGTGGAT
GATGAGAAGATCCTGGTGGAGCCCGCCTGCGGGGCAGCCCTGGCCGCTGTCTATAGCCAC
GTGATCCAGAAGCTCCAACTGGAGGGGAATCTCCGAACCCCGCTGCCATCCCTCGTGGTC
ATCGTCTGCGGGGGCAGCAACATCAGCCTGGCCCAGCTGCGGGCGCTCAAGGAACAGCTG
GGCATGACAAATAGGTTGCCCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 328 |
| Molecular Weight
| 34625.105 |
| Theoretical pI
| 8.01 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-serine dehydratase/L-threonine deaminase
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHF
VCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELA
KALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGL
QEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHP
IFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVV
IVCGGSNISLAQLRALKEQLGMTNRLPK
|
| External Links |
|---|
| GenBank ID Protein
| 158258957 |
| UniProtKB/Swiss-Prot ID
| P20132 |
| UniProtKB/Swiss-Prot Entry Name
| SDHL_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK292760 |
| GeneCard ID
| SDS |
| GenAtlas ID
| SDS |
| HGNC ID
| HGNC:10691 |
| References |
|---|
| General References
| Not Available |