Identification |
HMDB Protein ID
| CDBP00370 |
Secondary Accession Numbers
| Not Available |
Name
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
Description
| Not Available |
Synonyms
|
- 2-aminoadipate aminotransferase
- 2-aminoadipate transaminase
- AadAT
- Alpha-aminoadipate aminotransferase
- KAT/AadAT
- Kynurenine aminotransferase II
- Kynurenine--oxoglutarate aminotransferase II
- Kynurenine--oxoglutarate transaminase II
- Kynurenine--oxoglutarate transaminase 2
|
Gene Name
| AADAT |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in transferase activity, transferring nitrogenous groups |
Specific Function
| Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
|
GO Classification
|
Biological Process |
tryptophan catabolic process |
2-oxoglutarate metabolic process |
biosynthetic process |
glutamate metabolic process |
L-lysine catabolic process to acetyl-CoA via saccharopine |
lysine catabolic process |
tryptophan catabolic process to kynurenine |
Cellular Component |
mitochondrial matrix |
Function |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring nitrogenous groups |
cofactor binding |
pyridoxal phosphate binding |
Molecular Function |
kynurenine-oxoglutarate transaminase activity |
pyridoxal phosphate binding |
2-aminoadipate transaminase activity |
Process |
metabolic process |
biosynthetic process |
|
Cellular Location
|
- Mitochondrion (Potential)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | L-lysine degradation via saccharopine pathway | Not Available | Not Available | Lysine biosynthesis | Not Available | ![Map00300](https://www.genome.jp/kegg/misc/thumbnail/map00300.gif) | 2-Oxocarboxylic acid metabolism | Not Available | ![Map01210](https://www.genome.jp/kegg/misc/thumbnail/map01210.gif) | Lysine Degradation | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000029/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000029/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000029/thumb?image_type=simple) | ![Map00310](https://www.genome.jp/kegg/misc/thumbnail/map00310.gif) | Saccharopinuria/Hyperlysinemia II | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000112/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000112/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000112/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q33 |
SNPs
| AADAT |
Gene Sequence
|
>1278 bp
ATGAATTACGCACGGTTCATCACGGCAGCGAGCGCAGCCAGAAACCCTTCTCCCATCCGG
ACCATGACTGACATATTGAGCAGAGGACCAAAATCGATGATCTCCTTGGCTGGTGGCTTA
CCAAATCCAAACATGTTTCCTTTTAAGACTGCCGTAATCACTGTAGAAAATGGAAAGACC
ATCCAATTTGGAGAAGAGATGATGAAGAGAGCACTTCAGTATTCTCCGAGTGCTGGAATT
CCAGAGCTTTTGTCCTGGCTAAAACAGTTACAAATAAAATTGCATAATCCTCCTACCATC
CATTACCCACCCAGTCAAGGACAAATGGATCTATGTGTCACATCTGGCAGCCAACAAGGT
CTTTGTAAGGTGTTTGAAATGATCATTAATCCTGGAGATAATGTCCTCCTAGATGAACCT
GCTTATTCAGGAACTCTTCAAAGTCTGCACCCACTGGGCTGCAACATTATTAATGTTGCC
AGTGATGAAAGTGGGATTGTTCCAGATTCCCTAAGAGACATACTTTCCAGATGGAAACCA
GAAGATGCAAAGAATCCCCAGAAAAACACCCCCAAATTTCTTTATACTGTTCCAAATGGC
AACAACCCTACTGGAAACTCATTAACCAGTGAACGCAAAAAGGAAATCTATGAGCTTGCA
AGAAAATATGATTTCCTCATAATAGAAGATGATCCTTACTATTTTCTCCAGTTTAACAAG
TTCAGGGTACCAACATTTCTTTCCATGGATGTTGATGGACGTGTCATCAGAGCTGACTCT
TTTTCAAAAATCATTTCCTCTGGGTTGAGAATAGGATTTTTAACTGGTCCAAAACCCTTA
ATAGAGAGAGTTATTTTACACATACAAGTTTCAACATTGCACCCCAGCACTTTTAACCAG
CTCATGATATCACAGCTTCTACACGAATGGGGAGAAGAAGGTTTCATGGCTCATGTAGAC
AGGGTTATTGATTTCTATAGTAACCAGAAGGATGCAATACTGGCAGCTGCAGACAAGTGG
TTAACTGGTTTGGCAGAATGGCATGTTCCTGCTGCTGGAATGTTTTTATGGATTAAAGTT
AAAGGCATTAATGATGTAAAAGAACTGATTGAAGAAAAGGCCGTTAAGATGGGGGTATTA
ATGCTCCCTGGAAATGCTTTCTACGTCGATAGCTCAGCTCCTAGCCCTTACTTGAGAGCA
TCCTTCTCTTCAGCTTCTCCAGAACAGATGGATGTGGCCTTCCAGGTATTAGCACAACTT
ATAAAAGAATCTTTATGA
|
Protein Properties |
Number of Residues
| 425 |
Molecular Weight
| 47351.17 |
Theoretical pI
| 6.954 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q8N5Z0 |
UniProtKB/Swiss-Prot Entry Name
| AADAT_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF097994 |
GeneCard ID
| AADAT |
GenAtlas ID
| AADAT |
HGNC ID
| HGNC:17929 |
References |
General References
| Not Available |