Cannabis Compound Database: Showing Protein Aromatic-L-amino-acid decarboxylase (CDBP00272)

Identification Biological properties Gene properties Protein properties External links References XML Show 11 compounds

Identification

HMDB Protein ID

CDBP00272

Secondary Accession Numbers

Not Available

Name

Aromatic-L-amino-acid decarboxylase

Description

Not Available

Synonyms

AADC
DDC
DOPA decarboxylase

Gene Name

DDC

Protein Type

Enzyme

Biological Properties

General Function

Involved in carboxy-lyase activity

Specific Function

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

GO Classification

Biological Process
serotonin biosynthetic process
synaptic vesicle amine transport
cellular amino acid metabolic process
isoquinoline alkaloid metabolic process
cellular response to growth factor stimulus
circadian rhythm
catecholamine biosynthetic process
indolalkylamine biosynthetic process
cellular response to drug
cellular response to alkaloid
dopamine biosynthetic process
multicellular organismal aging
phytoalexin metabolic process
response to pyrethroid
Cellular Component
cytosol
synaptic vesicle
neuronal cell body
axon
Function
cofactor binding
pyridoxal phosphate binding
binding
catalytic activity
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
Molecular Function
aromatic-L-amino-acid decarboxylase activity
pyridoxal phosphate binding
amino acid binding
Process
metabolic process
cellular metabolism
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
physiological process
metabolism
cellular amino acid and derivative metabolic process
amino acid and derivative metabolism
amino acid metabolism

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
dopamine biosynthesis	Not Available	Not Available
Phenylalanine metabolism	Not Available
Serotonergic synapse	Not Available
Dopaminergic synapse	Not Available
Cocaine addiction	Not Available

Gene Properties

Chromosome Location

Locus

7p12.2

SNPs

DDC

Gene Sequence

>1443 bp
ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
TAG

Protein Properties

Number of Residues

480

Molecular Weight

53893.755

Theoretical pI

7.197

Pfam Domain Function

Pyridoxal_deC (PF00282 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Aromatic-L-amino-acid decarboxylase
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE

External Links

GenBank ID Protein

41393464

UniProtKB/Swiss-Prot ID

P20711

UniProtKB/Swiss-Prot Entry Name

DDC_HUMAN

PDB IDs

GenBank Gene ID

M76180

GeneCard ID

DDC