| Identification |
|---|
| HMDB Protein ID
| CDBP00272 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aromatic-L-amino-acid decarboxylase |
| Description
| Not Available |
| Synonyms
|
- AADC
- DDC
- DOPA decarboxylase
|
| Gene Name
| DDC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carboxy-lyase activity |
| Specific Function
| Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
|
| GO Classification
|
| Biological Process |
| phytoalexin metabolic process |
| response to pyrethroid |
| serotonin biosynthetic process |
| synaptic vesicle amine transport |
| cellular amino acid metabolic process |
| isoquinoline alkaloid metabolic process |
| cellular response to growth factor stimulus |
| circadian rhythm |
| catecholamine biosynthetic process |
| indolalkylamine biosynthetic process |
| cellular response to drug |
| cellular response to alkaloid |
| dopamine biosynthetic process |
| multicellular organismal aging |
| Cellular Component |
| cytosol |
| synaptic vesicle |
| neuronal cell body |
| axon |
| Function |
| carbon-carbon lyase activity |
| carboxy-lyase activity |
| cofactor binding |
| pyridoxal phosphate binding |
| binding |
| catalytic activity |
| lyase activity |
| Molecular Function |
| aromatic-L-amino-acid decarboxylase activity |
| pyridoxal phosphate binding |
| amino acid binding |
| Process |
| amino acid and derivative metabolism |
| amino acid metabolism |
| metabolic process |
| cellular metabolism |
| cellular metabolic process |
| organic acid metabolic process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| physiological process |
| metabolism |
| cellular amino acid and derivative metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | dopamine biosynthesis | Not Available | Not Available | | Phenylalanine metabolism | Not Available |  | | Serotonergic synapse | Not Available |  | | Dopaminergic synapse | Not Available |  | | Cocaine addiction | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p12.2 |
| SNPs
| DDC |
| Gene Sequence
|
>1443 bp
ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 480 |
| Molecular Weight
| 53893.755 |
| Theoretical pI
| 7.197 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aromatic-L-amino-acid decarboxylase
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
|
| External Links |
|---|
| GenBank ID Protein
| 41393464 |
| UniProtKB/Swiss-Prot ID
| P20711 |
| UniProtKB/Swiss-Prot Entry Name
| DDC_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M76180 |
| GeneCard ID
| DDC |
| GenAtlas ID
| DDC |
| HGNC ID
| HGNC:2719 |
| References |
|---|
| General References
| Not Available |