| Identification |
|---|
| HMDB Protein ID
| CDBP00448 |
| Secondary Accession Numbers
| Not Available |
| Name
| Kynurenine--oxoglutarate transaminase 1 |
| Description
| Not Available |
| Synonyms
|
- Cysteine-S-conjugate beta-lyase
- GTK
- Glutamine transaminase K
- Glutamine--phenylpyruvate transaminase
- KATI
- Kynurenine aminotransferase I
- Kynurenine--oxoglutarate transaminase I
|
| Gene Name
| CCBL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 1-aminocyclopropane-1-carboxylate synthase activity |
| Specific Function
| Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
|
| GO Classification
|
| Biological Process |
| tryptophan catabolic process |
| cellular amino acid biosynthetic process |
| L-kynurenine catabolic process |
| L-phenylalanine catabolic process |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| catalytic activity |
| transferase activity |
| lyase activity |
| transferase activity, transferring nitrogenous groups |
| cofactor binding |
| pyridoxal phosphate binding |
| carbon-sulfur lyase activity |
| 1-aminocyclopropane-1-carboxylate synthase activity |
| binding |
| Molecular Function |
| kynurenine-oxoglutarate transaminase activity |
| pyridoxal phosphate binding |
| cysteine-S-conjugate beta-lyase activity |
| glutamine-phenylpyruvate transaminase activity |
| L-glutamine:pyruvate aminotransferase activity |
| L-phenylalanine-oxaloacetate transaminase activity |
| L-phenylalanine:pyruvate aminotransferase activity |
| Process |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-kynurenine degradation | Not Available | Not Available | | Selenocompound metabolism | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.11 |
| SNPs
| CCBL1 |
| Gene Sequence
|
>1269 bp
ATGGCCAAACAGCTGCAGGCCCGAAGGCTAGACGGGATCGACTACAACCCCTGGGTGGAG
TTTGTGAAACTGGCCAGTGAGCATGACGTCGTGAACTTGGGCCAGGGCTTCCCGGATTTC
CCACCACCAGACTTTGCCGTGGAAGCCTTTCAGCACGCTGTCAGTGGAGACTTCATGCTT
AACCAGTACACCAAGACATTTGGTTACCCACCACTGACGAAGATCCTGGCAAGTTTCTTT
GGGGAGCTGCTGGGTCAGGAGATAGACCCGCTCAGGAATGTGCTGGTGACTGTTGGTGGC
TATGGGGCCCTGTTCACAGCCTTCCAGGCCCTGGTGGACGAAGGAGACGAGGTCATCATC
ATCGAACCCTTTTTTGACTGCTACGAGCCCATGACAATGATGGCAGGGGGTCGTCCTGTG
TTTGTGTCCCTGAAGCCGGGTCCCATCCAGAATGGAGAACTGGGTTCCAGCAGCAACTGG
CAGCTGGACCCCATGGAGCTGGCCGGCAAATTCACATCACGCACCAAAGCCCTGGTCCTC
AACACCCCCAACAACCCCCTGGGCAAGGTGTTCTCCAGGGAAGAGCTGGAGCTGGTGGCC
AGCCTTTGCCAGCAGCATGACGTGGTGTGTATCACTGATGAAGTCTACCAGTGGATGGTC
TACGACGGGCACCAGCACATCAGCATTGCCAGCCTCCCTGGCATGTGGGAACGGACCCTG
ACCATCGGCAGCGCCGGCAAGACCTTCAGCGCCACTGGCTGGAAGGTGGGCTGGGTCCTG
GGTCCAGATCACATCATGAAGCACCTGCGGACCGTGCACCAGAACTCCGTCTTCCACTGC
CCCACGCAGAGCCAGGCTGCAGTAGCCGAGAGCTTTGAACGGGAGCAGCTGCTCTTCCGC
CAACCCAGCAGCTACTTTGTGCAGTTCCCGCAGGCCATGCAGCGCTGCCGTGACCACATG
ATACGTAGCCTACAGTCAGTGGGCCTGAAGCCCATCATCCCTCAGGGCAGCTACTTCCTC
ATCACAGACATCTCAGACTTCAAGAGGAAGATGCCTGACTTGCCTGGAGCTGTGGATGAG
CCCTATGACAGACGCTTCGTCAAGTGGATGATCAAGAACAAGGGCTTGGTGGCCATCCCT
GTCTCCATCTTCTATAGTGTGCCACATCAGAAGCACTTTGACCACTATATCCGCTTCTGT
TTTGTGAAGGATGAAGCCACGCTCCAGGCCATGGACGAGAAGCTGCGGAAGTGGAAGGTG
GAACTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 422 |
| Molecular Weight
| 47874.765 |
| Theoretical pI
| 6.473 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Kynurenine--oxoglutarate transaminase 1
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
|
| External Links |
|---|
| GenBank ID Protein
| 758591 |
| UniProtKB/Swiss-Prot ID
| Q16773 |
| UniProtKB/Swiss-Prot Entry Name
| KAT1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X82224 |
| GeneCard ID
| CCBL1 |
| GenAtlas ID
| CCBL1 |
| HGNC ID
| HGNC:1564 |
| References |
|---|
| General References
| Not Available |