Cannabis Compound Database: Showing Compound Card for Niacinamide (CDB004912)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (34) Show 68 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:49:45 UTC

Updated at

2020-12-07 19:11:15 UTC

CannabisDB ID

CDB004912

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Niacinamide

Description

Niacinamide, also known as nicotinamid or nicovit, belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group. Niacinamide is a strong basic compound (based on its pKa). Niacinamide exists in all living species, ranging from bacteria to humans. niacinamide and phosphoribosyl pyrophosphate can be converted into nicotinic acid mononucleotide and phosphate through the action of the enzyme nicotinamide phosphoribosyltransferase. In humans, niacinamide is involved in the metabolic disorder called the nad+ signalling pathway (cancer). Niacinamide is an odorless tasting compound. Outside of the human body, Niacinamide is found, on average, in the highest concentration within a few different foods, such as common sages, milk (cow), and cocoa beans and in a lower concentration in common pea and beers. Niacinamide has also been detected, but not quantified in, several different foods, such as pineappple sages, boysenberries, cashew nuts, macadamia nut (m. tetraphylla), and sweet marjorams. This could make niacinamide a potential biomarker for the consumption of these foods. Niacinamide is a potentially toxic compound. A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. Niacinamide is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
3-Pyridinecarboxamide	ChEBI
beta-Pyridinecarboxamide	ChEBI
Niacin	ChEBI
Nicotinamid	ChEBI
Nicotinic acid amide	ChEBI
Nicotinsaeureamid	ChEBI
Nikotinamid	ChEBI
Nikotinsaeureamid	ChEBI
Vitamin b3	ChEBI
Vitamin PP	ChEBI
Nicotinamide	Kegg
b-Pyridinecarboxamide	Generator
Β-pyridinecarboxamide	Generator
Nicotinate amide	Generator
3-Carbamoylpyridine	HMDB
3-Pyridinecarboxylic acid amide	HMDB
Acid amide	HMDB
Amid kyseliny nikotinove	HMDB
Amide PP	HMDB
Aminicotin	HMDB
Amixicotyn	HMDB
Amnicotin	HMDB
Austrovit PP	HMDB
Benicot	HMDB
Delonin amide	HMDB
Dipegyl	HMDB
Dipigyl	HMDB
Endobion	HMDB
Factor PP	HMDB
Hansamid	HMDB
Inovitan PP	HMDB
m-(Aminocarbonyl)pyridine	HMDB
Mediatric	HMDB
NAM	HMDB
Nandervit-N	HMDB
Niacevit	HMDB
Niamide	HMDB
Niavit PP	HMDB
Nicamide	HMDB
Nicamina	HMDB
Nicamindon	HMDB
Nicasir	HMDB
Nicobion	HMDB
Nicofort	HMDB
Nicogen	HMDB
Nicomidol	HMDB
Nicosan 2	HMDB
Nicosylamide	HMDB
Nicota	HMDB
Nicotamide	HMDB
Nicotilamide	HMDB
Nicotililamido	HMDB
Nicotinamida	HMDB
Nicotinamidum	HMDB
Nicotine acid amide	HMDB
Nicotine amide	HMDB
Nicotinic amide	HMDB
Nicotinsaureamid	HMDB
Nicotol	HMDB
Nicotylamide	HMDB
Nicotylamidum	HMDB
Nicovel	HMDB
Nicovit	HMDB
Nicovitina	HMDB
Nicovitol	HMDB
Nicozymin	HMDB
Nictoamide	HMDB
Niko-tamin	HMDB
Niocinamide	HMDB
Niozymin	HMDB
Papulex	HMDB
Pelmin	HMDB
Pelmine	HMDB
Pelonin amide	HMDB
PP-Faktor	HMDB
Propamine a	HMDB
Pyridine-3-carboxylic acid amide	HMDB
Savacotyl	HMDB
Vi-nicotyl	HMDB
Vi-noctyl	HMDB
Witamina PP	HMDB
3 Pyridinecarboxamide	HMDB
Astra brand OF niacinamide	HMDB
b 3, Vitamin	HMDB
Niacinamide merck brand	HMDB
Pharmagenix brand OF niacinamide	HMDB
b3, Vitamin	HMDB
Enduramide	HMDB
Jenapharm, nicotinsäureamid	HMDB
Niacinamide jenapharm brand	HMDB
Niacinamide pharmagenix brand	HMDB
Jenapharm brand OF niacinamide	HMDB
Nicotinsäureamid jenapharm	HMDB
Vitamin b 3	HMDB
Merck brand OF niacinamide	HMDB
Niacinamide astra brand	HMDB
Niacinamide	ChEBI

Chemical Formula

C₆H₆N₂O

Average Molecular Weight

122.12

Monoisotopic Molecular Weight

122.048

IUPAC Name

pyridine-3-carboxamide

Traditional Name

nicotinamide

CAS Registry Number

98-92-0

SMILES

NC(=O)C1=CC=CN=C1

InChI Identifier

InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI Key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyridines and derivatives

Sub Class

Pyridinecarboxylic acids and derivatives

Direct Parent

Nicotinamides

Alternative Parents

Substituents

Nicotinamide
Heteroaromatic compound
Primary carboxylic acid amide
Carboxamide group
Azacycle
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

pyridine alkaloid (CHEBI:17154 )
pyridinecarboxamide (CHEBI:17154 )
Water-soluble vitamins (C00153 )
Pyridine alkaloids (C00153 )
a vitamin (NIACINAMIDE )
an aliphatic amide (NIACINAMIDE )

Ontology

Dermal

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Organ and components:

Tissue and substructures:

Biofluid and excreta:

Cell and elements:

Extracellular

Cell:

Role

Biological role:

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	130 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	500 mg/mL at 25 °C	Not Available
logP	-0.37	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-0.45	ALOGPS
logP	-0.39	ChemAxon
logS	-0.39	ALOGPS
pKa (Strongest Acidic)	13.39	ChemAxon
pKa (Strongest Basic)	3.63	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	55.98 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	32.98 m³·mol⁻¹	ChemAxon
Polarizability	11.71 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-0kor-9600000000-2b1c5667d92bc1b80b36	2014-09-20	View Spectrum
GC-MS	Niacinamide, 1 TMS, GC-MS Spectrum	splash10-004i-0900000000-acb6a21304b0c09c8472	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-004r-0900000000-ce86dcff0153b66dd538	Spectrum
GC-MS	Niacinamide, 1 TMS, GC-MS Spectrum	splash10-004i-9500000000-790385e574240b8d39de	Spectrum
GC-MS	Niacinamide, 2 TMS, GC-MS Spectrum	splash10-0udi-2910000000-d760b65bb76d6464038e	Spectrum
GC-MS	Niacinamide, 1 TMS, GC-MS Spectrum	splash10-004i-4900000000-47c6f72d1bb5465c1376	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-0kor-9800000000-1809e537780b814af0c9	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-0kor-9800000000-c4a5ff5285417499eff8	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-004i-0900000000-0e84a60cc2a2d44704f4	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-004i-0900000000-acb6a21304b0c09c8472	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-004r-0900000000-ce86dcff0153b66dd538	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-004i-9500000000-790385e574240b8d39de	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-0udi-2910000000-d760b65bb76d6464038e	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-004i-4900000000-47c6f72d1bb5465c1376	Spectrum
GC-MS	Niacinamide, non-derivatized, GC-MS Spectrum	splash10-004i-0900000000-23a567506bfbc259e77c	Spectrum
Predicted GC-MS	Niacinamide, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-05fr-8900000000-931c139355be3ef594f2	Spectrum
Predicted GC-MS	Niacinamide, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Niacinamide, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-00di-2900000000-72a7c92eb2667f5b6c3f	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-9000000000-6486d230a4a2fd4bab0e	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-001i-9000000000-6486d230a4a2fd4bab0e	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positive	splash10-0kor-9800000000-89d56b6cb7e033699d24	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-00di-0900000000-eed71abbb10ba926c13d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-00di-3900000000-0c62aa6aba6e23b6c195	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-001i-9100000000-4357a8833611d1756c59	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-001i-9000000000-c9685717817d0081fe6d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-0fc0-9000000000-ec0ccca306f38cf72a78	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-00di-4900000000-f6d71a6c467f84ddd6ab	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-001i-9100000000-62c4bd312efbfa37d1a1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-00di-4900000000-05714b528dc84942b9db	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-001i-9100000000-edb6a77c0dfdcbdacc5d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-00di-0900000000-eed71abbb10ba926c13d	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-00di-3900000000-0c62aa6aba6e23b6c195	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-001i-9100000000-4357a8833611d1756c59	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-001i-9000000000-c9685717817d0081fe6d	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0fc0-9000000000-ec0ccca306f38cf72a78	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-00di-0900000000-960acce7ead55399b5db	2017-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-0900000000-2c7ec333d35eb740520a	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0089-9600000000-466f98885e2efba73575	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0ue9-9200000000-6ef8d7e5edcdd0b02758	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-1900000000-f38177aa475e58941088	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00fr-9800000000-6a883d82fcd7c450f6ce	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9000000000-882d0c59d946a5087b9f	2015-05-27	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, DMSO-d6, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 25.16 MHz, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Nicotinate and Nicotinamide Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nicotinamide N-methyltransferase	NNMT	11q23.1	P40261	details
Tankyrase-2	TNKS2	10q23.3	Q9H2K2	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Poly [ADP-ribose] polymerase 3	PARP3	3p21.31-p21.1	Q9Y6F1	details
Ecto-ADP-ribosyltransferase 3	ART3	4p15.1-p14	Q13508	details
Ecto-ADP-ribosyltransferase 5	ART5	11p15.4	Q96L15	details
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	11p15	P52961	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
ADP-ribosyl cyclase 2	BST1	4p15	Q10588	details
Poly [ADP-ribose] polymerase 2	PARP2	14q11.2-q12	Q9UGN5	details
ADP-ribosyl cyclase 1	CD38	4p15	P28907	details
Ecto-ADP-ribosyltransferase 4	ART4	12p13-p12	Q93070	details
Poly [ADP-ribose] polymerase 4	PARP4	13q11	Q9UKK3	details
L-lactate dehydrogenase A chain	LDHA	11p15.4	P00338	details
Purine nucleoside phosphorylase	PNP	14q13.1	P00491	details
Nicotinamide phosphoribosyltransferase	NAMPT	7q22.3	P43490	details
Poly [ADP-ribose] polymerase 10	PARP10	8q24.3	Q53GL7	details
Poly [ADP-ribose] polymerase 11	PARP11	12p13.3	Q9NR21	details
Poly [ADP-ribose] polymerase 12	PARP12	7q34	Q9H0J9	details
Poly [ADP-ribose] polymerase 14	PARP14	3q21.1	Q460N5	details
Poly [ADP-ribose] polymerase 15	PARP15	3q21.1	Q460N3	details
Mono [ADP-ribose] polymerase PARP16	PARP16	15q22.31	Q8N5Y8	details
Poly [ADP-ribose] polymerase 6	PARP6	15q23	Q2NL67	details
Poly [ADP-ribose] polymerase 8	PARP8	5q11.1	Q8N3A8	details
Poly [ADP-ribose] polymerase 9	PARP9	3q21	Q8IXQ6	details
TCDD-inducible poly [ADP-ribose] polymerase	TIPARP	3q25.31	Q7Z3E1	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details
NAD-dependent protein deacetylase sirtuin-2	SIRT2	19q13	Q8IXJ6	details
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	SIRT3	11p15.5	Q9NTG7	details
NAD-dependent protein deacetylase sirtuin-4	SIRT4	12q	Q9Y6E7	details
NAD-dependent protein deacylase sirtuin-5, mitochondrial	SIRT5	6p23	Q9NXA8	details
NAD-dependent protein deacetylase sirtuin-7	SIRT7	17q25	Q9NRC8	details
tRNA 2'-phosphotransferase 1	TRPT1	11q13.1	Q86TN4	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tankyrase-2	TNKS2	10q23.3	Q9H2K2	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
Cytochrome P450 3A4	CYP3A4	7q21.1	P08684	details
Cytochrome P450 2E1	CYP2E1	10q24.3-qter	P05181	details
Cytochrome P450 2D6	CYP2D6	22q13.1	P10635	details
Poly [ADP-ribose] polymerase 12	PARP12	7q34	Q9H0J9	details
TCDD-inducible poly [ADP-ribose] polymerase	TIPARP	3q25.31	Q7Z3E1	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details
NAD-dependent protein deacetylase sirtuin-2	SIRT2	19q13	Q8IXJ6	details
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	SIRT3	11p15.5	Q9NTG7	details
NAD-dependent protein deacetylase sirtuin-4	SIRT4	12q	Q9Y6E7	details
NAD-dependent protein deacylase sirtuin-5, mitochondrial	SIRT5	6p23	Q9NXA8	details
NAD-dependent protein deacetylase sirtuin-7	SIRT7	17q25	Q9NRC8	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tankyrase-2	TNKS2	10q23.3	Q9H2K2	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
ADP-ribosyl cyclase 1	CD38	4p15	P28907	details
TCDD-inducible poly [ADP-ribose] polymerase	TIPARP	3q25.31	Q7Z3E1	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
ADP-ribosyl cyclase 1	CD38	4p15	P28907	details
Nicotinamide phosphoribosyltransferase	NAMPT	7q22.3	P43490	details
Poly [ADP-ribose] polymerase 14	PARP14	3q21.1	Q460N5	details
Poly [ADP-ribose] polymerase 15	PARP15	3q21.1	Q460N3	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details
NAD-dependent protein deacetylase sirtuin-2	SIRT2	19q13	Q8IXJ6	details
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	SIRT3	11p15.5	Q9NTG7	details
NAD-dependent protein deacetylase sirtuin-4	SIRT4	12q	Q9Y6E7	details
NAD-dependent protein deacylase sirtuin-5, mitochondrial	SIRT5	6p23	Q9NXA8	details
NAD-dependent protein deacetylase sirtuin-7	SIRT7	17q25	Q9NRC8	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001406

DrugBank ID

DB02701

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

17154

References

General References

Not Available

Only showing the first 10 proteins. There are 68 proteins in total.

Show All

Enzymes

Enzyme Details

1. Nicotinamide N-methyltransferase

General function:: Involved in methyltransferase activity
Specific function:: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
Gene Name:: NNMT
Uniprot ID:: P40261
Molecular weight:: 29573.705

Enzyme Details

2. Tankyrase-2

General function:: Involved in NAD+ ADP-ribosyltransferase activity
Specific function:: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
Gene Name:: TNKS2
Uniprot ID:: Q9H2K2
Molecular weight:: 126916.895

Enzyme Details

3. NAD-dependent protein deacetylase sirtuin-6

General function:: Involved in zinc ion binding
Specific function:: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Gene Name:: SIRT6
Uniprot ID:: Q8N6T7
Molecular weight:: 36064.295

Enzyme Details

4. Poly [ADP-ribose] polymerase 3

General function:: Involved in NAD+ ADP-ribosyltransferase activity
Specific function:: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Gene Name:: PARP3
Uniprot ID:: Q9Y6F1
Molecular weight:: 60845.685

Enzyme Details

5. Ecto-ADP-ribosyltransferase 3

General function:: Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Specific function:: Not Available
Gene Name:: ART3
Uniprot ID:: Q13508
Molecular weight:: 43922.97

Enzyme Details

6. Ecto-ADP-ribosyltransferase 5

General function:: Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Specific function:: Not Available
Gene Name:: ART5
Uniprot ID:: Q96L15
Molecular weight:: 32053.48

Enzyme Details

7. GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

General function:: Involved in NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Specific function:: Has ADP-ribosyltransferase activity toward GLP1R.
Gene Name:: ART1
Uniprot ID:: P52961
Molecular weight:: 36334.32

Enzyme Details

8. Tankyrase-1

General function:: Involved in NAD+ ADP-ribosyltransferase activity
Specific function:: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.
Gene Name:: TNKS
Uniprot ID:: O95271
Molecular weight:: 142038.18

Enzyme Details

9. Poly [ADP-ribose] polymerase 1

General function:: Involved in DNA binding
Specific function:: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Gene Name:: PARP1
Uniprot ID:: P09874
Molecular weight:: 113082.945

Enzyme Details

10. ADP-ribosyl cyclase 2

General function:: Involved in NAD+ nucleosidase activity
Specific function:: Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
Gene Name:: BST1
Uniprot ID:: Q10588
Molecular weight:: 35723.545

Only showing the first 10 proteins. There are 68 proteins in total.

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Showing Compound Card for Niacinamide (CDB004912)

Structure for CDB004912 (Niacinamide)

Enzymes