Cannabis Compound Database: Showing Compound Card for Propionyl-CoA (CDB005128)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (105)transporters (7) Show 136 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:12:08 UTC

Updated at

2020-11-18 16:39:25 UTC

CannabisDB ID

CDB005128

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Propionyl-CoA

Description

Propionyl-CoA, also known as propanoyl-CoA, belongs to the class of organic compounds known as acyl coas. These are organic compounds containing a coenzyme A substructure linked to an acyl chain. Propionyl-CoA is a strong basic compound (based on its pKa). Propionyl-CoA is a potentially toxic compound. Propionyl-CoA is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Methylacetyl-CoA	HMDB
2-Methylacetyl-coenzyme A	HMDB
alpha-Methylacetyl-CoA	HMDB
alpha-Methylacetyl-coenzyme A	HMDB
Propanoyl-CoA	HMDB
Propanoyl-coenzyme A	HMDB
Propionyl-coenzyme A	HMDB

Chemical Formula

C₂₄H₄₀N₇O₁₇P₃S

Average Molecular Weight

823.6

Monoisotopic Molecular Weight

823.1414

IUPAC Name

{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({[hydroxy({3-hydroxy-2,2-dimethyl-3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy})phosphoryl]oxy})phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid

Traditional Name

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-({[hydroxy([hydroxy(3-hydroxy-2,2-dimethyl-3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy)phosphoryl]oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxyphosphonic acid

CAS Registry Number

317-66-8

SMILES

CCC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N

InChI Identifier

InChI=1S/C24H40N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,34-35H,4-10H2,1-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/t13-,17-,18-,19?,23-/m1/s1

InChI Key

QAQREVBBADEHPA-UXYNFSPESA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as acyl coas. These are organic compounds containing a coenzyme A substructure linked to an acyl chain.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acyl thioesters

Direct Parent

Acyl CoAs

Alternative Parents

Substituents

Coenzyme a or derivatives
Purine ribonucleoside 3',5'-bisphosphate
Purine ribonucleoside bisphosphate
Purine ribonucleoside diphosphate
Ribonucleoside 3'-phosphate
Pentose phosphate
Pentose-5-phosphate
Beta amino acid or derivatives
Glycosyl compound
N-glycosyl compound
6-aminopurine
Monosaccharide phosphate
Organic pyrophosphate
Pentose monosaccharide
Imidazopyrimidine
Purine
Monoalkyl phosphate
Aminopyrimidine
Imidolactam
N-acyl-amine
N-substituted imidazole
Organic phosphoric acid derivative
Monosaccharide
Pyrimidine
Alkyl phosphate
Fatty amide
Phosphoric acid ester
Tetrahydrofuran
Imidazole
Azole
Heteroaromatic compound
Carbothioic s-ester
Secondary alcohol
Thiocarboxylic acid ester
Carboxamide group
Secondary carboxylic acid amide
Amino acid or derivatives
Sulfenyl compound
Thiocarboxylic acid or derivatives
Organoheterocyclic compound
Azacycle
Oxacycle
Carboxylic acid derivative
Organosulfur compound
Organic oxygen compound
Hydrocarbon derivative
Carbonyl group
Organic nitrogen compound
Primary amine
Organopnictogen compound
Organic oxide
Organooxygen compound
Organonitrogen compound
Alcohol
Amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Ontology

Not Available

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.2	ALOGPS
logP	-5.2	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Acidic)	0.82	ChemAxon
pKa (Strongest Basic)	4.01	ChemAxon
Physiological Charge	-4	ChemAxon
Hydrogen Acceptor Count	17	ChemAxon
Hydrogen Donor Count	9	ChemAxon
Polar Surface Area	363.63 Å²	ChemAxon
Rotatable Bond Count	21	ChemAxon
Refractivity	176.83 m³·mol⁻¹	ChemAxon
Polarizability	72.52 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Propionyl-CoA, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-1921000110-a902ba2e846c5fa3a6f6	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0019-1911000000-73f7c171e662ee7ccd1d	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0019-1910000000-e82bdc99f5bada8c440e	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0a7i-9830232560-d45384d1d1a3fe0dd614	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-4910200000-2a67602fe8e4a74a6abe	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-056r-8900100000-d3e8a1b9393d73c218b4	2016-08-03	View Spectrum

NMR

Not Available

Pathways

Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Malonyl-CoA decarboxylase, mitochondrial	MLYCD	16q24	O95822	details
Carnitine O-acetyltransferase	CRAT	9q34.1	P43155	details
3-ketoacyl-CoA thiolase, mitochondrial	ACAA2	18q21.1	P42765	details
Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	20q11.22	Q9NR19	details
Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	20p11.23-p11.21	Q9NUB1	details
3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	3p22.2	P09110	details
Trifunctional enzyme subunit beta, mitochondrial	HADHB	2p23	P55084	details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	14q24.3	Q02252	details
Long-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADL	2q34	P28330	details
Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	12q24.31	P16219	details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	1p31	P11310	details
Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	17q25.1	Q15067	details
Peroxisomal acyl-coenzyme A oxidase 2	ACOX2	3p14.3	Q99424	details
Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	15q14-q15	P26440	details
Peroxisomal acyl-coenzyme A oxidase 3	ACOX3	4p15.3	O15254	details
Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	19p13.2	Q92947	details
Hepatic triacylglycerol lipase	LIPC	15q21-q23	P11150	details
Diacylglycerol O-acyltransferase 1	DGAT1	8q24.3	O75907	details
Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	3q21-q22	P05166	details
Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	13q32	P05165	details
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	BCKDHB	6q14.1	P21953	details
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	BCKDHA	19q13.1-q13.2	P12694	details
Acyl-CoA desaturase	SCD	10q24.31	O00767	details
Non-specific lipid-transfer protein	SCP2	1p32	P22307	details
Sterol O-acyltransferase 2	SOAT2	12q13.13	O75908	details
Sterol O-acyltransferase 1	SOAT1	1q25	P35610	details
Bile acid-CoA:amino acid N-acyltransferase	BAAT	9q22.3	Q14032	details
Long-chain-fatty-acid--CoA ligase 4	ACSL4	Xq22.3-q23	O60488	details
Long-chain-fatty-acid--CoA ligase 1	ACSL1	4q35	P33121	details
Long-chain-fatty-acid--CoA ligase 6	ACSL6	5q31	Q9UKU0	details
Long-chain-fatty-acid--CoA ligase 5	ACSL5	10q25.1-q25.2	Q9ULC5	details
Long-chain-fatty-acid--CoA ligase 3	ACSL3	2q34-q35	O95573	details
Glycerol-3-phosphate acyltransferase 1, mitochondrial	GPAM	10q25.2	Q9HCL2	details
Trans-2-enoyl-CoA reductase, mitochondrial	MECR	1p35.3	Q9BV79	details
Peroxisomal trans-2-enoyl-CoA reductase	PECR	2q35	Q9BY49	details
Cytosolic acyl coenzyme A thioester hydrolase	ACOT7	1p36	O00154	details
Acyl-coenzyme A thioesterase 2, mitochondrial	ACOT2	14q24.3	P49753	details
Acyl-coenzyme A thioesterase 4	ACOT4	14q24.3	Q8N9L9	details
Acyl-coenzyme A thioesterase 8	ACOT8	20q13.12	O14734	details
Dihydroxyacetone phosphate acyltransferase	GNPAT	1q42	O15228	details
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma	AGPAT3	21q22.3	Q9NRZ7	details
1-acyl-sn-glycerol-3-phosphate acyltransferase beta	AGPAT2	9q34.3	O15120	details
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha	AGPAT1	6p21.3	Q99943	details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	10q26.13	P45954	details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Peroxisome proliferator-activated receptor gamma	PPARG	3p25	P37231	details
Peroxisome proliferator-activated receptor alpha	PPARA	22q12-q13.1\|22q13.31	Q07869	details
Peroxisome proliferator-activated receptor delta	PPARD	6p21.2	Q03181	details
Acyl-CoA-binding protein	DBI	2q12-q21	P07108	details
Fatty acid-binding protein, heart	FABP3	1p33-p32	P05413	details
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon	AGPAT5	8p23.1	Q9NUQ2	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial	DBT	1p31	P11182	details
2-acylglycerol O-acyltransferase 2	MOGAT2	11q13.5	Q3SYC2	details
Long-chain fatty acid transport protein 3	SLC27A3	1q21.3	Q5K4L6	details
Acyl-CoA dehydrogenase family member 10	ACAD10	12q24.12	Q6JQN1	details
Acyl-CoA dehydrogenase family member 11	ACAD11	3q22.1	Q709F0	details
Glycerol-3-phosphate acyltransferase 4	AGPAT6	8p11.21	Q86UL3	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Diacylglycerol O-acyltransferase 2	DGAT2	11q13.5	Q96PD7	details
1-acyl-sn-glycerol-3-phosphate acyltransferase delta	AGPAT4	6q26	Q9NRZ5	details
2-acylglycerol O-acyltransferase 1	MOGAT1	2q36.1	Q96PD6	details
Isobutyryl-CoA dehydrogenase, mitochondrial	ACAD8	11q25	Q9UKU7	details
Acyl-CoA dehydrogenase family member 9, mitochondrial	ACAD9	3q21.3	Q9H845	details
Long-chain fatty acid transport protein 4	SLC27A4	9q34.11	Q6P1M0	details
Fatty acyl-CoA reductase 1	FAR1	11p15.2	Q8WVX9	details
Fatty acyl-CoA reductase 2	FAR2	12p11.22	Q96K12	details
Acyl-CoA wax alcohol acyltransferase 1	AWAT1	Xq13.1	Q58HT5	details
Acyl-CoA wax alcohol acyltransferase 2	AWAT2	Xq13.1	Q6E213	details
Diacylglycerol O-acyltransferase 2-like protein 6	DGAT2L6		Q6ZPD8	details
Putative diacylglycerol O-acyltransferase 2-like protein 7	DGAT2L7	7q22.1	Q6IED9	details
2-acylglycerol O-acyltransferase 3	MOGAT3	7q22.1	Q86VF5	details
Lysophospholipid acyltransferase 5	LPCAT3	12p13	Q6P1A2	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Lysocardiolipin acyltransferase 1	LCLAT1	2p23.1	Q6UWP7	details
Lysophospholipid acyltransferase LPCAT4	LPCAT4	15q14	Q643R3	details
Glycerol-3-phosphate acyltransferase 3	AGPAT9	4q21.23	Q53EU6	details
Glycine N-acyltransferase	GLYAT	11q12.1	Q6IB77	details
Glycine N-acyltransferase-like protein 1	GLYATL1	11q12.1	Q969I3	details
Glycine N-acyltransferase-like protein 2	GLYATL2	11q12.1	Q8WU03	details
Enoyl-CoA delta isomerase 2, mitochondrial	ECI2	6p24.3	O75521	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details
ACSS2 protein	ACSS2	20q11.22	Q96FY7	details
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADVL	17p13.1	P49748	details
Acyl-coenzyme A oxidase-like protein	ACOXL	2q13	Q9NUZ1	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Peroxisomal coenzyme A diphosphatase NUDT7	NUDT7	16q23.1	P0C024	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details
Glycerol-3-phosphate acyltransferase 2, mitochondrial	GPAT2	2q11.1	Q6NUI2	details
Peroxisomal D3,D2-enoyl-CoA isomerase isoform 1 variant			Q53GC8	details
Nef-associated protein 1	C9orf156	9q22.33	Q9BU70	details
Acyl-coenzyme A thioesterase 9, mitochondrial	ACOT9		Q9Y305	details
Acyl-CoA synthetase family member 3, mitochondrial	ACSF3	16q24.3	Q4G176	details
Acyl-coenzyme A thioesterase 1	ACOT1	14q24.3	Q86TX2	details
Cytosolic acyl coenzyme A thioester hydrolase-like	ACOT7L		Q6ZUV0	details
Acyl-CoA synthetase family member 2, mitochondrial	ACSF2	17q21.33	Q96CM8	details
Acyl-coenzyme A thioesterase 11	ACOT11	1p32.3	Q8WXI4	details
Long-chain-fatty-acid--CoA ligase ACSBG2	ACSBG2	19p13.3	Q5FVE4	details
Long-chain-fatty-acid--CoA ligase ACSBG1	ACSBG1	15q23-q24	Q96GR2	details
Acyl-CoA synthetase short-chain family member 3, mitochondrial	ACSS3	12q21.31	Q9H6R3	details
Ethylmalonyl-CoA decarboxylase	ECHDC1	6q22.33	Q9NTX5	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Non-specific lipid-transfer protein	SCP2	1p32	P22307	details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Fatty acid-binding protein, heart	FABP3	1p33-p32	P05413	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Long-chain fatty acid transport protein 1	SLC27A1	19p13.11	Q6PCB7	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details
Fatty acid-binding protein, intestinal	FABP2	4q28-q31	P12104	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	13q32	P05165	details
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	BCKDHA	19q13.1-q13.2	P12694	details
Acyl-CoA desaturase	SCD	10q24.31	O00767	details
Trans-2-enoyl-CoA reductase, mitochondrial	MECR	1p35.3	Q9BV79	details
Peroxisome proliferator-activated receptor gamma	PPARG	3p25	P37231	details
Peroxisome proliferator-activated receptor alpha	PPARA	22q12-q13.1\|22q13.31	Q07869	details
Peroxisome proliferator-activated receptor delta	PPARD	6p21.2	Q03181	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Lysophosphatidylcholine acyltransferase 1	LPCAT1	5p15.33	Q8NF37	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Peroxisomal coenzyme A diphosphatase NUDT7	NUDT7	16q23.1	P0C024	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Peroxisome proliferator-activated receptor gamma	PPARG	3p25	P37231	details
Peroxisome proliferator-activated receptor alpha	PPARA	22q12-q13.1\|22q13.31	Q07869	details
Peroxisome proliferator-activated receptor delta	PPARD	6p21.2	Q03181	details
Benzodiazepine receptor ligand	BRL		Q71U42	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Peroxisome proliferator-activated receptor gamma	PPARG	3p25	P37231	details
Peroxisome proliferator-activated receptor alpha	PPARA	22q12-q13.1\|22q13.31	Q07869	details
Peroxisome proliferator-activated receptor delta	PPARD	6p21.2	Q03181	details
Isobutyryl-CoA dehydrogenase, mitochondrial	ACAD8	11q25	Q9UKU7	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001275

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB022529

KNApSAcK ID

Not Available

Chemspider ID

388310

KEGG Compound ID

C00100

BioCyc ID

Not Available

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

15539

References

General References

Not Available

Only showing the first 10 proteins. There are 136 proteins in total.

Show All

Enzymes

Enzyme Details

1. Malonyl-CoA decarboxylase, mitochondrial

General function:: Involved in malonyl-CoA decarboxylase activity
Specific function:: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.
Gene Name:: MLYCD
Uniprot ID:: O95822
Molecular weight:: 55002.94

Enzyme Details

2. Carnitine O-acetyltransferase

General function:: Involved in acyltransferase activity
Specific function:: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Gene Name:: CRAT
Uniprot ID:: P43155
Molecular weight:: 70875.095

Enzyme Details

3. 3-ketoacyl-CoA thiolase, mitochondrial

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
Gene Name:: ACAA2
Uniprot ID:: P42765
Molecular weight:: 41923.82

Enzyme Details

4. Acetyl-coenzyme A synthetase, cytoplasmic

General function:: Involved in acetate-CoA ligase activity
Specific function:: Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name:: ACSS2
Uniprot ID:: Q9NR19
Molecular weight:: 78579.11

Enzyme Details

5. Acetyl-coenzyme A synthetase 2-like, mitochondrial

General function:: Involved in acetate-CoA ligase activity
Specific function:: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:: ACSS1
Uniprot ID:: Q9NUB1
Molecular weight:: 74625.88

Enzyme Details

6. 3-ketoacyl-CoA thiolase, peroxisomal

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Not Available
Gene Name:: ACAA1
Uniprot ID:: P09110
Molecular weight:: 34664.46

Enzyme Details

7. Trifunctional enzyme subunit beta, mitochondrial

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Not Available
Gene Name:: HADHB
Uniprot ID:: P55084
Molecular weight:: 51293.955

Enzyme Details

8. Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Gene Name:: ALDH6A1
Uniprot ID:: Q02252
Molecular weight:: 57839.31

Enzyme Details

9. Long-chain specific acyl-CoA dehydrogenase, mitochondrial

General function:: Involved in acyl-CoA dehydrogenase activity
Specific function:: Not Available
Gene Name:: ACADL
Uniprot ID:: P28330
Molecular weight:: 47655.275

Enzyme Details

10. Short-chain specific acyl-CoA dehydrogenase, mitochondrial

General function:: Involved in acyl-CoA dehydrogenase activity
Specific function:: Not Available
Gene Name:: ACADS
Uniprot ID:: P16219
Molecular weight:: 44296.705

Transporters

Enzyme Details

1. Non-specific lipid-transfer protein

General function:: Involved in oxidoreductase activity
Specific function:: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
Gene Name:: SCP2
Uniprot ID:: P22307
Molecular weight:: 34974.505

Enzyme Details

2. Very long-chain acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Gene Name:: SLC27A2
Uniprot ID:: O14975
Molecular weight:: 64614.99

Enzyme Details

3. Fatty acid-binding protein, heart

General function:: Involved in negative regulation of cell proliferation
Specific function:: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters
Gene Name:: FABP3
Uniprot ID:: P05413
Molecular weight:: 14857.9

Enzyme Details

4. Bile acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Gene Name:: SLC27A5
Uniprot ID:: Q9Y2P5
Molecular weight:: 75384.375

Enzyme Details

5. Long-chain fatty acid transport protein 1

General function:: Lipid transport and metabolism
Specific function:: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids
Gene Name:: SLC27A1
Uniprot ID:: Q6PCB7
Molecular weight:: 71107.5

Enzyme Details

6. Acyl-CoA synthetase family member 4

General function:: Involved in acyl carrier activity
Specific function:: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:: AASDH
Uniprot ID:: Q4L235
Molecular weight:: 122596.1

Enzyme Details

7. Fatty acid-binding protein, intestinal

General function:: Involved in binding
Specific function:: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor
Gene Name:: FABP2
Uniprot ID:: P12104
Molecular weight:: 15207.2

Only showing the first 10 proteins. There are 136 proteins in total.

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Showing Compound Card for Propionyl-CoA (CDB005128)

Structure for CDB005128 (Propionyl-CoA)

Enzymes

Transporters