Record Information
Version1.0
Created at2020-04-17 19:09:13 UTC
Updated at2020-12-07 19:11:35 UTC
CannabisDB IDCDB005099
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameQH2
DescriptionQH2, also known as COQH2 or ubiquinol, belongs to the class of organic compounds known as ubiquinols. These are coenzyme Q derivatives containing a 5, 6-dimethoxy-3-methylbenzene-1,4-diol moiety to which an isoprenyl group is attached at ring position 2(or 6). QH2 is possibly neutral. QH2 is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
CoQH2Kegg
Coenzymes QH2HMDB
Reduced ubiquinoneHMDB
UbiquinolHMDB
Ubiquinone-1HMDB
Coenzyme Q10, reducedHMDB
Ubiquinol-10HMDB
Chemical Formula(C5H8)nC14H20O4
Average Molecular WeightNot Available
Monoisotopic Molecular WeightNot Available
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number56275-39-9
SMILES
COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC
InChI Identifier
InChI=1S/C19H28O4/c1-12(2)8-7-9-13(3)10-11-15-14(4)16(20)18(22-5)19(23-6)17(15)21/h8,10,20-21H,7,9,11H2,1-6H3/b13-10+
InChI KeyRNUCUWWMTTWKAH-JLHYYAGUSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as ubiquinols. These are coenzyme Q derivatives containing a 5, 6-dimethoxy-3-methylbenzene-1,4-diol moiety to which an isoprenyl group is attached at ring position 2(or 6).
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassPrenol lipids
Sub ClassQuinone and hydroquinone lipids
Direct ParentUbiquinols
Alternative Parents
Substituents
  • Ubiquinol skeleton
  • Aromatic monoterpenoid
  • Methoxyphenol
  • Monocyclic monoterpenoid
  • Monoterpenoid
  • O-dimethoxybenzene
  • Dimethoxybenzene
  • Anisole
  • Phenoxy compound
  • Hydroquinone
  • M-cresol
  • Methoxybenzene
  • O-cresol
  • Phenol ether
  • Alkyl aryl ether
  • Phenol
  • Toluene
  • Monocyclic benzene moiety
  • Benzenoid
  • Ether
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Organooxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP4.41ALOGPS
logS-4.4ALOGPS
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSQH2, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a4r-4193000000-48fe18179b80bb21b5c7Spectrum
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-0239000000-bbff225e78add9a452cd2019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-05fs-5941000000-9f3d49dffc1fee6bce792019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0690-9510000000-6b82f15187f9c07ab9642019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0009000000-538077b5337d583f80b62019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00kb-1195000000-ee266dcd83a76f9e49732019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0aba-5390000000-aa9db1cbd8b9e542a9242019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-1229000000-bcae25f8e04aef2f7f2e2021-09-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-4971000000-a2a095c9a71f782655e62021-09-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-05pw-6930000000-256eb8fb25dcd7ed3a832021-09-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0009000000-0385a0c55ac9f0aa5ed42021-09-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-014i-0559000000-c001cae147213a35d7d52021-09-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0kdr-1981000000-d586cd100610d78946f22021-09-23View Spectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
NADH-ubiquinone oxidoreductase chain 1MT-ND1P03886 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1NDUFB114q32.12O75438 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialNDUFS21q23O75306 details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialSDHC1q23.3Q99643 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12NDUFA1212q22Q9UI09 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1NDUFA1O15239 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2NDUFA4L212q13.3Q9NRX3 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3NDUFA319q13.42O95167 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8NDUFA89q33.2P51970 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4NDUFA47p21.3O00483 details
NADH-ubiquinone oxidoreductase chain 4LMT-ND4LP03901 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11NDUFA1119p13.3Q86Y39 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialNDUFS45q11.1O43181 details
NADH-ubiquinone oxidoreductase chain 5MT-ND5P03915 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialNDUFS311p11.11O75489 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5NDUFS51p34.2-p33O43920 details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialNDUFV218p11.22P19404 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialNDUFA102q37.3O95299 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6NDUFA622q13.2P56556 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4NDUFB43q13.33O95168 details
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialSDHA5p15P31040 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNDUFS811q13O00217 details
NADH-ubiquinone oxidoreductase chain 2MT-ND2P03891 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7NDUFA719p13.2O95182 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2NDUFA25q31O43678 details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNDUFS12q33-q34P28331 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialNDUFB53q26.33O43674 details
NADH dehydrogenase [ubiquinone] 1 subunit C2NDUFC211q14.1O95298 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3NDUFB32q31.3O43676 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7NDUFB719p13.12P17568 details
Acyl carrier protein, mitochondrialNDUFAB116p12.2O14561 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5NDUFA57q32Q16718 details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialETFDH4q32-q35Q16134 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialNDUFA912p13.3Q16795 details
NADH-ubiquinone oxidoreductase chain 4MT-ND4P03905 details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialSDHD11q23O14521 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS719p13.3O75251 details
NADH-ubiquinone oxidoreductase chain 3MT-ND3P03897 details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUFV111q13P49821 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9NDUFB98q13.3Q9Y6M9 details
NADH-ubiquinone oxidoreductase chain 6MT-ND6P03923 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13NDUFA1319p13.2Q9P0J0 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialNDUFS65p15.33O75380 details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSDHB1p36.1-p35P21912 details
Cytochrome b-c1 complex subunit 7UQCRB8q22P14927 details
Cytochrome b-c1 complex subunit Rieske, mitochondrialUQCRFS119q12P47985 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialNDUFB11Q9NX14 details
Cytochrome b-c1 complex subunit 8UQCRQ5q31.1O14949 details
NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDaNDUFB27q34A4D1T5 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11NDUFA1119p13.3Q86Y39 details
Acyl carrier protein, mitochondrialNDUFAB116p12.2O14561 details
Cytochrome b-c1 complex subunit 9UQCR1022cen-q12.3Q9UDW1 details
Cytochrome b-c1 complex subunit 7UQCRB8q22P14927 details
Cytochrome b-c1 complex subunit Rieske, mitochondrialUQCRFS119q12P47985 details
Cytochrome b-c1 complex subunit 6, mitochondrialUQCRH1p34.1P07919 details
Cytochrome b-c1 complex subunit 8UQCRQ5q31.1O14949 details
Cytochrome b-c1 complex subunit 10UQCR1119p13.3O14957 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialNDUFS21q23O75306 details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialSDHC1q23.3Q99643 details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialNDUFV218p11.22P19404 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNDUFS811q13O00217 details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNDUFS12q33-q34P28331 details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialETFDH4q32-q35Q16134 details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialSDHD11q23O14521 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS719p13.3O75251 details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUFV111q13P49821 details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSDHB1p36.1-p35P21912 details
Cytochrome b-c1 complex subunit 2, mitochondrialUQCRC216p12P22695 details
Cytochrome b-c1 complex subunit 1, mitochondrialUQCRC13p21.3P31930 details
Cytochrome b-c1 complex subunit Rieske, mitochondrialUQCRFS119q12P47985 details
Cytochrome c1, heme protein, mitochondrialCYC18q24.3P08574 details
ReceptorsNot Available
Transcriptional FactorsNot Available
Concentrations Data
Not Available
HMDB IDHMDB0001304
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022543
KNApSAcK IDNot Available
Chemspider ID4444052
KEGG Compound IDC00390
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkCoenzyme Q10
METLIN ID6146
PubChem Compound5280344
PDB IDNot Available
ChEBI IDNot Available
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 71 proteins in total.

Enzymes

General function:
Involved in oxidation reduction
Specific function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:
MT-ND1
Uniprot ID:
P03886
Molecular weight:
35660.055
General function:
Involved in NADH dehydrogenase activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFB1
Uniprot ID:
O75438
Molecular weight:
6961.2
General function:
Involved in oxidoreductase activity, acting on NADH or NADPH
Specific function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:
NDUFS2
Uniprot ID:
O75306
Molecular weight:
51851.59
General function:
Involved in succinate dehydrogenase activity
Specific function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Gene Name:
SDHC
Uniprot ID:
Q99643
Molecular weight:
16650.185
General function:
Involved in NADH dehydrogenase (ubiquinone) activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA12
Uniprot ID:
Q9UI09
Molecular weight:
17114.4
General function:
Involved in NADH dehydrogenase (ubiquinone) activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA1
Uniprot ID:
O15239
Molecular weight:
8072.3
General function:
Not Available
Specific function:
Not Available
Gene Name:
NDUFA4L2
Uniprot ID:
Q9NRX3
Molecular weight:
9965.6
General function:
Involved in NADH dehydrogenase (ubiquinone) activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA3
Uniprot ID:
O95167
Molecular weight:
9278.8
General function:
Involved in NADH dehydrogenase (ubiquinone) activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA8
Uniprot ID:
P51970
Molecular weight:
20104.9
General function:
Involved in NADH dehydrogenase (ubiquinone) activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA4
Uniprot ID:
O00483
Molecular weight:
9369.8

Transporters

General function:
Involved in protein transporter activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA11
Uniprot ID:
Q86Y39
Molecular weight:
14852.0
General function:
Involved in acyl carrier activity
Specific function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain
Gene Name:
NDUFAB1
Uniprot ID:
O14561
Molecular weight:
17417.1
General function:
Involved in ubiquinol-cytochrome-c reductase activity
Specific function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1
Gene Name:
UQCR10
Uniprot ID:
Q9UDW1
Molecular weight:
7308.4
General function:
Involved in ubiquinol-cytochrome-c reductase activity
Specific function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping
Gene Name:
UQCRB
Uniprot ID:
P14927
Molecular weight:
13530.3
General function:
Involved in oxidoreductase activity
Specific function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex (By similarity).
Gene Name:
UQCRFS1
Uniprot ID:
P47985
Molecular weight:
29667.695
General function:
Involved in ubiquinol-cytochrome-c reductase activity
Specific function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1
Gene Name:
UQCRH
Uniprot ID:
P07919
Molecular weight:
10738.7
General function:
Involved in ubiquinol-cytochrome-c reductase activity
Specific function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone
Gene Name:
UQCRQ
Uniprot ID:
O14949
Molecular weight:
9906.3
General function:
Involved in ubiquinol-cytochrome-c reductase activity
Specific function:
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor
Gene Name:
UQCR11
Uniprot ID:
O14957
Molecular weight:
6569.7

Only showing the first 10 proteins. There are 71 proteins in total.