Record Information
Version1.0
Created at2020-04-17 18:49:39 UTC
Updated at2020-12-07 19:11:15 UTC
CannabisDB IDCDB004911
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameGuanosine monophosphate
DescriptionGuanosine monophosphate, also known as guanylic acid or 5'-GMP, belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. Guanosine monophosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Guanosine monophosphate exists in all living species, ranging from bacteria to humans. Within humans, guanosine monophosphate participates in a number of enzymatic reactions. In particular, guanosine triphosphate and guanosine monophosphate can be biosynthesized from diguanosine tetraphosphate; which is catalyzed by the enzyme bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. In addition, guanosine monophosphate can be biosynthesized from guanosine diphosphate; which is mediated by the enzyme ectonucleoside triphosphate diphosphohydrolase 5. In humans, guanosine monophosphate is involved in purine metabolism. A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase. Outside of the human body, Guanosine monophosphate has been detected, but not quantified in, several different foods, such as rosemaries, common chokecherries, pigeon pea, rices, and horseradish tree. This could make guanosine monophosphate a potential biomarker for the consumption of these foods. Guanosine monophosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
5'-GMPChEBI
GMPChEBI
Guanosine 5'-phosphateChEBI
Guanosine-5'-monophosphateChEBI
Guanylic acidChEBI
pGChEBI
Guanosine 5'-monophosphateKegg
Guanosine 5'-phosphoric acidGenerator
Guanosine-5'-monophosphoric acidGenerator
GuanylateGenerator
Guanosine 5'-monophosphoric acidGenerator
Guanosine monophosphoric acidGenerator
e 626HMDB
Guanidine monophosphateHMDB
Guanosine 5'-phosphorateHMDB
Guanosine-5'-phosphateHMDB
Guanosine-phosphateHMDB
5' Guanylic acidHMDB
Acid, 5'-guanylicHMDB
Acid, guanylicHMDB
Guanosine 5' monophosphateHMDB
5'-monoPhosphate, guanosineHMDB
monoPhosphate, guanosineHMDB
5'-Guanylic acidHMDB
Chemical FormulaC10H14N5O8P
Average Molecular Weight363.22
Monoisotopic Molecular Weight363.058
IUPAC Name{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Traditional Nameguanylate
CAS Registry Number85-32-5
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
InChI Identifier
InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChI KeyRQFCJASXJCIDSX-UUOKFMHZSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine ribonucleotides
Direct ParentPurine ribonucleoside monophosphates
Alternative Parents
Substituents
  • Purine ribonucleoside monophosphate
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • 6-oxopurine
  • Hypoxanthine
  • Monosaccharide phosphate
  • Pentose monosaccharide
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Monoalkyl phosphate
  • Pyrimidone
  • Alkyl phosphate
  • Pyrimidine
  • Monosaccharide
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Tetrahydrofuran
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Vinylogous amide
  • 1,2-diol
  • Secondary alcohol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Primary amine
  • Organic nitrogen compound
  • Amine
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Alcohol
  • Organonitrogen compound
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility369 mg/mLNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-2ALOGPS
logP-3.1ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)1.29ChemAxon
pKa (Strongest Basic)0.38ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area201.75 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity75.49 m³·mol⁻¹ChemAxon
Polarizability30.7 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
GC-MSGuanosine monophosphate, 6 TMS, GC-MS Spectrumsplash10-014i-1942000000-27fc2e135f86071ba4d7Spectrum
GC-MSGuanosine monophosphate, non-derivatized, GC-MS Spectrumsplash10-014i-1942000000-27fc2e135f86071ba4d7Spectrum
GC-MSGuanosine monophosphate, non-derivatized, GC-MS Spectrumsplash10-014i-0941000000-245c5258141d8d2a9fa5Spectrum
Predicted GC-MSGuanosine monophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0002-9722000000-9155df338c7516c297b6Spectrum
Predicted GC-MSGuanosine monophosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-01ot-9522200000-3e2591b21841c753ec13Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0udi-0901000000-fbce35f7dfa73ab5fc11Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0udi-0900000000-764722cc1b8cc2aaa480Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0udi-0900000000-c268cdce8dfd6c39fa3cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-03di-0409000000-309e438ad8b6162df850Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positivesplash10-0udi-0904000000-cf72d0459316801b014eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0udi-0900000000-abc7bfe7620db1c34775Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-01t9-9114000000-9a1071a2e17ea3ca268cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-01t9-9113000000-05a8989070e3b89138f1Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-01t9-9114000000-9a1071a2e17ea3ca268cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-01t9-9113000000-05a8989070e3b89138f1Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-03di-0409000000-309e438ad8b6162df850Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0udi-0904000000-cf72d0459316801b014eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-0udi-0900000000-abc7bfe7620db1c34775Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0913000000-05cd931f142e4b624c8bSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0900000000-318d089a94a5bcfd20f2Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0udi-0900000000-e616291ba80c4abf405cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0imi-7709000000-6c811759b6f078f642a2Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0fb9-9800000000-59c4ae8bf5bfa0d23da1Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9100000000-73f60c52b80206170819Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
5'-nucleotidaseNT5E6q14-q21P21589 details
Cytosolic 5'-nucleotidase 1BNT5C1B2p24.2Q96P26 details
Cytosolic 5'-nucleotidase 1ANT5C1A1p34.3-p33Q9BXI3 details
5'(3')-deoxyribonucleotidase, cytosolic typeNT5CQ8TCD5 details
5'(3')-deoxyribonucleotidase, mitochondrialNT5MQ9NPB1 details
Ectonucleoside triphosphate diphosphohydrolase 1ENTPD110q24P49961 details
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Ectonucleoside triphosphate diphosphohydrolase 3ENTPD33p21.3O75355 details
Inosine triphosphate pyrophosphataseITPA20pQ9BY32 details
Adenine phosphoribosyltransferaseAPRT16q24P07741 details
Hypoxanthine-guanine phosphoribosyltransferaseHPRT1Xq26.1P00492 details
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6H12p13Q13956 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1APDE1A2q32.1P54750 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8APDE8A15q25.3O60658 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BPDE1B12q13Q01064 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BPDE3B11p15.1Q13370 details
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'PDE6C10q24P51160 details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7APDE7A8q13Q13946 details
GMP synthase [glutamine-hydrolyzing]GMPS3q24P49915 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase APDE3A12p12Q14432 details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10APDE10A6q26Q9Y233 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPDE1C7p14.3Q14123 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4BPDE4B1p31Q07343 details
cAMP-specific 3',5'-cyclic phosphodiesterase 7BPDE7B6q23-q24Q9NP56 details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9APDE9A21q22.3O76083 details
cGMP-dependent 3',5'-cyclic phosphodiesterasePDE2A11q13.4O00408 details
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]NUDT29p13P50583 details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaPDE6A5q31.2-q34P16499 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BPDE8B5q13.3O95263 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4CPDE4C19p13.11Q08493 details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaPDE6B4p16.3P35913 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4DPDE4D5q12Q08499 details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6G17q25P18545 details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaPDE6D2q35-q36O43924 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4APDE4A19p13.2P27815 details
cGMP-specific 3',5'-cyclic phosphodiesterasePDE5A4q27O76074 details
Protein-glutamine gamma-glutamyltransferase ETGM320q11.2Q08188 details
GMP reductase 2GMPR214q12Q9P2T1 details
GMP reductase 1GMPR6p23P36959 details
Ectonucleoside triphosphate diphosphohydrolase 4ENTPD48p21.3Q9Y227 details
Ectonucleoside triphosphate diphosphohydrolase 6ENTPD620p11.21O75354 details
Ectonucleoside triphosphate diphosphohydrolase 5ENTPD514q24O75356 details
Bifunctional purine biosynthesis protein PURHATIC2q35P31939 details
Guanylate kinaseGUK11q32-q41Q16774 details
Disks large homolog 4DLG417p13.1P78352 details
Rho guanine nucleotide exchange factor 1ARHGEF119q13.13Q92888 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGNAS20q13.3P63092 details
VinexinSORBS38p21.3O60504 details
GTPase HRasHRAS11p15.5P01112 details
Guanine nucleotide-binding protein G(q) subunit alphaGNAQ9q21P50148 details
Guanine nucleotide-binding protein subunit alpha-11GNA1119p13.3P29992 details
Guanine nucleotide-binding protein G(t) subunit alpha-1GNAT13p21P11488 details
Protein ALEXGNAS20q13.3P84996 details
Lysophosphatidic acid receptor 2LPAR219p12Q9HBW0 details
Cytosolic 5'-nucleotidase 3NT5C37p14.3Q9H0P0 details
ENTPD4 proteinENTPD48p21.3Q8NE73 details
Cytosolic purine 5'-nucleotidaseNT5C210q24.32P49902 details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11APDE11A2q31.2Q9HCR9 details
Ectonucleoside triphosphate diphosphohydrolase 8ENTPD89q34.3Q5MY95 details
GTPase-activating protein and VPS9 domain-containing protein 1GAPVD19q33.3Q14C86 details
Probable E3 ubiquitin-protein ligase HERC1HERC115q22Q15751 details
Rho-related GTP-binding protein RhoURHOU1q42.11-q42.3Q7L0Q8 details
Protein RCC2RCC21p36.13Q9P258 details
Protein very KINDKNDC110q26.3Q76NI1 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Cyclic nucleotide-gated cation channel alpha-3CNGA32q11.2Q16281 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
5'-nucleotidaseNT5E6q14-q21P21589 details
Cytosolic 5'-nucleotidase 1BNT5C1B2p24.2Q96P26 details
Cytosolic 5'-nucleotidase 1ANT5C1A1p34.3-p33Q9BXI3 details
5'(3')-deoxyribonucleotidase, cytosolic typeNT5CQ8TCD5 details
5'(3')-deoxyribonucleotidase, mitochondrialNT5MQ9NPB1 details
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Inosine triphosphate pyrophosphataseITPA20pQ9BY32 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1APDE1A2q32.1P54750 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8APDE8A15q25.3O60658 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BPDE1B12q13Q01064 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BPDE3B11p15.1Q13370 details
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'PDE6C10q24P51160 details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7APDE7A8q13Q13946 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase APDE3A12p12Q14432 details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10APDE10A6q26Q9Y233 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPDE1C7p14.3Q14123 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4BPDE4B1p31Q07343 details
cAMP-specific 3',5'-cyclic phosphodiesterase 7BPDE7B6q23-q24Q9NP56 details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9APDE9A21q22.3O76083 details
cGMP-dependent 3',5'-cyclic phosphodiesterasePDE2A11q13.4O00408 details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaPDE6A5q31.2-q34P16499 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BPDE8B5q13.3O95263 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4CPDE4C19p13.11Q08493 details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaPDE6B4p16.3P35913 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4DPDE4D5q12Q08499 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4APDE4A19p13.2P27815 details
cGMP-specific 3',5'-cyclic phosphodiesterasePDE5A4q27O76074 details
GMP reductase 2GMPR214q12Q9P2T1 details
GMP reductase 1GMPR6p23P36959 details
Cytosolic 5'-nucleotidase 3NT5C37p14.3Q9H0P0 details
Cytosolic purine 5'-nucleotidaseNT5C210q24.32P49902 details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11APDE11A2q31.2Q9HCR9 details
Dedicator of cytokinesis protein 2DOCK25q35.1Q92608 details
Ras guanyl-releasing protein 3RASGRP32p25.1-p24.1Q8IV61 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6H12p13Q13956 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1APDE1A2q32.1P54750 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BPDE1B12q13Q01064 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BPDE3B11p15.1Q13370 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPDE1C7p14.3Q14123 details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6G17q25P18545 details
Atrial natriuretic peptide receptor 2NPR29p21-p12P20594 details
Atrial natriuretic peptide receptor 1NPR11q21-q22P16066 details
Heat-stable enterotoxin receptorGUCY2C12p12P25092 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2GNG214q21P59768 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGNAS20q13.3P63092 details
Guanine nucleotide-binding protein G(q) subunit alphaGNAQ9q21P50148 details
Guanine nucleotide-binding protein subunit alpha-11GNA1119p13.3P29992 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11GNG117q21P61952 details
Guanine nucleotide-binding protein G(t) subunit alpha-1GNAT13p21P11488 details
Lysophosphatidic acid receptor 2LPAR219p12Q9HBW0 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10GNG109q31.3P50151 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12GNG121p31.3Q9UBI6 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13GNG1316p13.3Q9P2W3 details
Guanine nucleotide-binding protein G(T) subunit gamma-T1GNGT17q21.3P63211 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3GNG311p11P63215 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4GNG41q42.3P50150 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5GNG51p22P63218 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7GNG719p13.3O60262 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8GNG819q13.32Q9UK08 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2GNGT217q21O14610 details
T-lymphoma invasion and metastasis-inducing protein 2TIAM26q25.2Q8IVF5 details
Guanine nucleotide-binding protein G(i) subunit alpha-1GNAI17q21P63096 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasGNAS20q13.3Q5JWF2 details
Guanine nucleotide-binding protein subunit alpha-14GNA149q21O95837 details
Guanine nucleotide-binding protein G(k) subunit alphaGNAI31p13P08754 details
Guanine nucleotide-binding protein G(i) subunit alpha-2GNAI23p21P04899 details
Guanine nucleotide-binding protein G(t) subunit alpha-2GNAT21p13.1P19087 details
Guanine nucleotide-binding protein G(o) subunit alphaGNAO116q13P09471 details
Guanine nucleotide-binding protein subunit alpha-13GNA1317q24.3Q14344 details
Guanine nucleotide binding protein (G protein), alpha 14GNA149q21B1ALW3 details
Guanine nucleotide-binding protein subunit alpha-12GNA127p22.2Q03113 details
Growth factor receptor-bound protein 2GRB217q24-q25P62993 details
Guanine nucleotide binding protein (G protein), q polypeptideGNAQ9q21B1AM21 details
Guanine nucleotide-binding protein G(z) subunit alphaGNAZ22q11.22P19086 details
Guanine nucleotide-binding protein G(olf) subunit alphaGNAL18p11.22-p11.21P38405 details
Guanine nucleotide-binding protein subunit alpha-15GNA1519p13.3P30679 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8APDE8A15q25.3O60658 details
cGMP-dependent 3',5'-cyclic phosphodiesterasePDE2A11q13.4O00408 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BPDE8B5q13.3O95263 details
Concentrations Data
Not Available
HMDB IDHMDB0001397
DrugBank IDDB01972
Phenol Explorer Compound IDNot Available
FoodDB IDFDB030896
KNApSAcK IDC00019635
Chemspider ID6545
KEGG Compound IDC00144
BioCyc IDGMP
BiGG ID34024
Wikipedia LinkGuanosine_monophosphate
METLIN ID6216
PubChem Compound6804
PDB IDNot Available
ChEBI ID17345
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 144 proteins in total.

Enzymes

General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:
NT5E
Uniprot ID:
P21589
Molecular weight:
57948.125
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Molecular weight:
68803.055
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Molecular weight:
41020.145
General function:
Involved in metal ion binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Molecular weight:
Not Available
General function:
Involved in phosphatase activity
Specific function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Molecular weight:
Not Available
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
General function:
Involved in hydrolase activity
Specific function:
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Gene Name:
ITPA
Uniprot ID:
Q9BY32
Molecular weight:
16833.23
General function:
Involved in adenine phosphoribosyltransferase activity
Specific function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Gene Name:
APRT
Uniprot ID:
P07741
Molecular weight:
19607.535

Transporters

General function:
Involved in ion channel activity
Specific function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones
Gene Name:
CNGA3
Uniprot ID:
Q16281
Molecular weight:
78837.4

Only showing the first 10 proteins. There are 144 proteins in total.