Cannabis Compound Database: Showing Compound Card for Guanosine monophosphate (CDB004911)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (64)transporters (1) Show 144 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:49:39 UTC

Updated at

2020-12-07 19:11:15 UTC

CannabisDB ID

CDB004911

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Guanosine monophosphate

Description

Guanosine monophosphate, also known as guanylic acid or 5'-GMP, belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. Guanosine monophosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Guanosine monophosphate exists in all living species, ranging from bacteria to humans. Within humans, guanosine monophosphate participates in a number of enzymatic reactions. In particular, guanosine triphosphate and guanosine monophosphate can be biosynthesized from diguanosine tetraphosphate; which is catalyzed by the enzyme bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. In addition, guanosine monophosphate can be biosynthesized from guanosine diphosphate; which is mediated by the enzyme ectonucleoside triphosphate diphosphohydrolase 5. In humans, guanosine monophosphate is involved in purine metabolism. A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase. Outside of the human body, Guanosine monophosphate has been detected, but not quantified in, several different foods, such as rosemaries, common chokecherries, pigeon pea, rices, and horseradish tree. This could make guanosine monophosphate a potential biomarker for the consumption of these foods. Guanosine monophosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
5'-GMP	ChEBI
GMP	ChEBI
Guanosine 5'-phosphate	ChEBI
Guanosine-5'-monophosphate	ChEBI
Guanylic acid	ChEBI
pG	ChEBI
Guanosine 5'-monophosphate	Kegg
Guanosine 5'-phosphoric acid	Generator
Guanosine-5'-monophosphoric acid	Generator
Guanylate	Generator
Guanosine 5'-monophosphoric acid	Generator
Guanosine monophosphoric acid	Generator
e 626	HMDB
Guanidine monophosphate	HMDB
Guanosine 5'-phosphorate	HMDB
Guanosine-5'-phosphate	HMDB
Guanosine-phosphate	HMDB
5' Guanylic acid	HMDB
Acid, 5'-guanylic	HMDB
Acid, guanylic	HMDB
Guanosine 5' monophosphate	HMDB
5'-monoPhosphate, guanosine	HMDB
monoPhosphate, guanosine	HMDB
5'-Guanylic acid	HMDB

Chemical Formula

C₁₀H₁₄N₅O₈P

Average Molecular Weight

363.22

Monoisotopic Molecular Weight

363.058

IUPAC Name

{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

Traditional Name

guanylate

CAS Registry Number

85-32-5

SMILES

NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1

InChI Identifier

InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

InChI Key

RQFCJASXJCIDSX-UUOKFMHZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside monophosphates

Alternative Parents

Substituents

Purine ribonucleoside monophosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-oxopurine
Hypoxanthine
Monosaccharide phosphate
Pentose monosaccharide
Imidazopyrimidine
Purine
Aminopyrimidine
Monoalkyl phosphate
Pyrimidone
Alkyl phosphate
Pyrimidine
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Phosphoric acid ester
Tetrahydrofuran
Azole
Imidazole
Heteroaromatic compound
Vinylogous amide
1,2-diol
Secondary alcohol
Oxacycle
Azacycle
Organoheterocyclic compound
Primary amine
Organic nitrogen compound
Amine
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic oxygen compound
Alcohol
Organonitrogen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

guanosine 5'-phosphate (CHEBI:17345 )
purine ribonucleoside 5'-monophosphate (CHEBI:17345 )
Ribonucleotides (C00144 )

Ontology

Disposition

Source:

Endogenous

Biological location:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Biological role:

Molecular messenger:

Second messenger

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	369 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-2	ALOGPS
logP	-3.1	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	1.29	ChemAxon
pKa (Strongest Basic)	0.38	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	201.75 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	75.49 m³·mol⁻¹	ChemAxon
Polarizability	30.7 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Guanosine monophosphate, 6 TMS, GC-MS Spectrum	splash10-014i-1942000000-27fc2e135f86071ba4d7	Spectrum
GC-MS	Guanosine monophosphate, non-derivatized, GC-MS Spectrum	splash10-014i-1942000000-27fc2e135f86071ba4d7	Spectrum
GC-MS	Guanosine monophosphate, non-derivatized, GC-MS Spectrum	splash10-014i-0941000000-245c5258141d8d2a9fa5	Spectrum
Predicted GC-MS	Guanosine monophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9722000000-9155df338c7516c297b6	Spectrum
Predicted GC-MS	Guanosine monophosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-01ot-9522200000-3e2591b21841c753ec13	Spectrum
Predicted GC-MS	Guanosine monophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0udi-0901000000-fbce35f7dfa73ab5fc11	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0udi-0900000000-764722cc1b8cc2aaa480	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0udi-0900000000-c268cdce8dfd6c39fa3c	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-03di-0409000000-309e438ad8b6162df850	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-0udi-0904000000-cf72d0459316801b014e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-0udi-0900000000-abc7bfe7620db1c34775	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-01t9-9114000000-9a1071a2e17ea3ca268c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-01t9-9113000000-05a8989070e3b89138f1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-01t9-9114000000-9a1071a2e17ea3ca268c	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-01t9-9113000000-05a8989070e3b89138f1	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-03di-0409000000-309e438ad8b6162df850	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-0udi-0904000000-cf72d0459316801b014e	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-0udi-0900000000-abc7bfe7620db1c34775	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9000000000-c340c748805ec82deb0d	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-03di-3009000000-5d594db970a4fea1099e	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9011000000-8335076473133728e58f	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Positive	splash10-0udi-0904000000-cf72d0459316801b014e	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900000000-1f479e6ff94baf0265bc	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-1900000000-1dd27aac9ee9a0882191	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0913000000-05cd931f142e4b624c8b	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900000000-318d089a94a5bcfd20f2	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-0900000000-e616291ba80c4abf405c	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0imi-7709000000-6c811759b6f078f642a2	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0fb9-9800000000-59c4ae8bf5bfa0d23da1	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9100000000-73f60c52b80206170819	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcription/Translation	Not Available	Not Available
Purine Metabolism
Glutamate Metabolism
Adenosine Deaminase Deficiency		Not Available
Adenylosuccinate Lyase Deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
5'-nucleotidase	NT5E	6q14-q21	P21589	details
Cytosolic 5'-nucleotidase 1B	NT5C1B	2p24.2	Q96P26	details
Cytosolic 5'-nucleotidase 1A	NT5C1A	1p34.3-p33	Q9BXI3	details
5'(3')-deoxyribonucleotidase, cytosolic type	NT5C		Q8TCD5	details
5'(3')-deoxyribonucleotidase, mitochondrial	NT5M		Q9NPB1	details
Ectonucleoside triphosphate diphosphohydrolase 1	ENTPD1	10q24	P49961	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Ectonucleoside triphosphate diphosphohydrolase 3	ENTPD3	3p21.3	O75355	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
Adenine phosphoribosyltransferase	APRT	16q24	P07741	details
Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	Xq26.1	P00492	details
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	12p13	Q13956	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	2q32.1	P54750	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	15q25.3	O60658	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	12q13	Q01064	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	11p15.1	Q13370	details
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	PDE6C	10q24	P51160	details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	8q13	Q13946	details
GMP synthase [glutamine-hydrolyzing]	GMPS	3q24	P49915	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	12p12	Q14432	details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	6q26	Q9Y233	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	PDE1C	7p14.3	Q14123	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	1p31	Q07343	details
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	6q23-q24	Q9NP56	details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	21q22.3	O76083	details
cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	11q13.4	O00408	details
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]	NUDT2	9p13	P50583	details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	PDE6A	5q31.2-q34	P16499	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	5q13.3	O95263	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	19p13.11	Q08493	details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	PDE6B	4p16.3	P35913	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	5q12	Q08499	details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	17q25	P18545	details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	PDE6D	2q35-q36	O43924	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	19p13.2	P27815	details
cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	4q27	O76074	details
Protein-glutamine gamma-glutamyltransferase E	TGM3	20q11.2	Q08188	details
GMP reductase 2	GMPR2	14q12	Q9P2T1	details
GMP reductase 1	GMPR	6p23	P36959	details
Ectonucleoside triphosphate diphosphohydrolase 4	ENTPD4	8p21.3	Q9Y227	details
Ectonucleoside triphosphate diphosphohydrolase 6	ENTPD6	20p11.21	O75354	details
Ectonucleoside triphosphate diphosphohydrolase 5	ENTPD5	14q24	O75356	details
Bifunctional purine biosynthesis protein PURH	ATIC	2q35	P31939	details
Guanylate kinase	GUK1	1q32-q41	Q16774	details
Disks large homolog 4	DLG4	17p13.1	P78352	details
Rho guanine nucleotide exchange factor 1	ARHGEF1	19q13.13	Q92888	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	20q13.3	P63092	details
Vinexin	SORBS3	8p21.3	O60504	details
GTPase HRas	HRAS	11p15.5	P01112	details
Guanine nucleotide-binding protein G(q) subunit alpha	GNAQ	9q21	P50148	details
Guanine nucleotide-binding protein subunit alpha-11	GNA11	19p13.3	P29992	details
Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	3p21	P11488	details
Protein ALEX	GNAS	20q13.3	P84996	details
Lysophosphatidic acid receptor 2	LPAR2	19p12	Q9HBW0	details
Cytosolic 5'-nucleotidase 3	NT5C3	7p14.3	Q9H0P0	details
ENTPD4 protein	ENTPD4	8p21.3	Q8NE73	details
Cytosolic purine 5'-nucleotidase	NT5C2	10q24.32	P49902	details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	2q31.2	Q9HCR9	details
Ectonucleoside triphosphate diphosphohydrolase 8	ENTPD8	9q34.3	Q5MY95	details
GTPase-activating protein and VPS9 domain-containing protein 1	GAPVD1	9q33.3	Q14C86	details
Probable E3 ubiquitin-protein ligase HERC1	HERC1	15q22	Q15751	details
Rho-related GTP-binding protein RhoU	RHOU	1q42.11-q42.3	Q7L0Q8	details
Protein RCC2	RCC2	1p36.13	Q9P258	details
Protein very KIND	KNDC1	10q26.3	Q76NI1	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Cyclic nucleotide-gated cation channel alpha-3	CNGA3	2q11.2	Q16281	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
5'-nucleotidase	NT5E	6q14-q21	P21589	details
Cytosolic 5'-nucleotidase 1B	NT5C1B	2p24.2	Q96P26	details
Cytosolic 5'-nucleotidase 1A	NT5C1A	1p34.3-p33	Q9BXI3	details
5'(3')-deoxyribonucleotidase, cytosolic type	NT5C		Q8TCD5	details
5'(3')-deoxyribonucleotidase, mitochondrial	NT5M		Q9NPB1	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	2q32.1	P54750	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	15q25.3	O60658	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	12q13	Q01064	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	11p15.1	Q13370	details
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	PDE6C	10q24	P51160	details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	8q13	Q13946	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	12p12	Q14432	details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	6q26	Q9Y233	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	PDE1C	7p14.3	Q14123	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	1p31	Q07343	details
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	6q23-q24	Q9NP56	details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	21q22.3	O76083	details
cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	11q13.4	O00408	details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	PDE6A	5q31.2-q34	P16499	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	5q13.3	O95263	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	19p13.11	Q08493	details
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	PDE6B	4p16.3	P35913	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	5q12	Q08499	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	19p13.2	P27815	details
cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	4q27	O76074	details
GMP reductase 2	GMPR2	14q12	Q9P2T1	details
GMP reductase 1	GMPR	6p23	P36959	details
Cytosolic 5'-nucleotidase 3	NT5C3	7p14.3	Q9H0P0	details
Cytosolic purine 5'-nucleotidase	NT5C2	10q24.32	P49902	details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	2q31.2	Q9HCR9	details
Dedicator of cytokinesis protein 2	DOCK2	5q35.1	Q92608	details
Ras guanyl-releasing protein 3	RASGRP3	2p25.1-p24.1	Q8IV61	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	12p13	Q13956	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	2q32.1	P54750	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	12q13	Q01064	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	11p15.1	Q13370	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	PDE1C	7p14.3	Q14123	details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	17q25	P18545	details
Atrial natriuretic peptide receptor 2	NPR2	9p21-p12	P20594	details
Atrial natriuretic peptide receptor 1	NPR1	1q21-q22	P16066	details
Heat-stable enterotoxin receptor	GUCY2C	12p12	P25092	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	GNG2	14q21	P59768	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	20q13.3	P63092	details
Guanine nucleotide-binding protein G(q) subunit alpha	GNAQ	9q21	P50148	details
Guanine nucleotide-binding protein subunit alpha-11	GNA11	19p13.3	P29992	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	GNG11	7q21	P61952	details
Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	3p21	P11488	details
Lysophosphatidic acid receptor 2	LPAR2	19p12	Q9HBW0	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	GNG10	9q31.3	P50151	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNG12	1p31.3	Q9UBI6	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNG13	16p13.3	Q9P2W3	details
Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNGT1	7q21.3	P63211	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNG3	11p11	P63215	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	GNG4	1q42.3	P50150	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNG5	1p22	P63218	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	GNG7	19p13.3	O60262	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNG8	19q13.32	Q9UK08	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	GNGT2	17q21	O14610	details
T-lymphoma invasion and metastasis-inducing protein 2	TIAM2	6q25.2	Q8IVF5	details
Guanine nucleotide-binding protein G(i) subunit alpha-1	GNAI1	7q21	P63096	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	GNAS	20q13.3	Q5JWF2	details
Guanine nucleotide-binding protein subunit alpha-14	GNA14	9q21	O95837	details
Guanine nucleotide-binding protein G(k) subunit alpha	GNAI3	1p13	P08754	details
Guanine nucleotide-binding protein G(i) subunit alpha-2	GNAI2	3p21	P04899	details
Guanine nucleotide-binding protein G(t) subunit alpha-2	GNAT2	1p13.1	P19087	details
Guanine nucleotide-binding protein G(o) subunit alpha	GNAO1	16q13	P09471	details
Guanine nucleotide-binding protein subunit alpha-13	GNA13	17q24.3	Q14344	details
Guanine nucleotide binding protein (G protein), alpha 14	GNA14	9q21	B1ALW3	details
Guanine nucleotide-binding protein subunit alpha-12	GNA12	7p22.2	Q03113	details
Growth factor receptor-bound protein 2	GRB2	17q24-q25	P62993	details
Guanine nucleotide binding protein (G protein), q polypeptide	GNAQ	9q21	B1AM21	details
Guanine nucleotide-binding protein G(z) subunit alpha	GNAZ	22q11.22	P19086	details
Guanine nucleotide-binding protein G(olf) subunit alpha	GNAL	18p11.22-p11.21	P38405	details
Guanine nucleotide-binding protein subunit alpha-15	GNA15	19p13.3	P30679	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	15q25.3	O60658	details
cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	11q13.4	O00408	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	5q13.3	O95263	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001397

DrugBank ID

DB01972

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Guanosine_monophosphate

METLIN ID

6216

PubChem Compound

6804

PDB ID

Not Available

ChEBI ID

17345

References

General References

Not Available

Only showing the first 10 proteins. There are 144 proteins in total.

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Enzymes

Enzyme Details

1. 5'-nucleotidase

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:: NT5E
Uniprot ID:: P21589
Molecular weight:: 57948.125

Enzyme Details

2. Cytosolic 5'-nucleotidase 1B

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:: NT5C1B
Uniprot ID:: Q96P26
Molecular weight:: 68803.055

Enzyme Details

3. Cytosolic 5'-nucleotidase 1A

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:: NT5C1A
Uniprot ID:: Q9BXI3
Molecular weight:: 41020.145

Enzyme Details

4. 5'(3')-deoxyribonucleotidase, cytosolic type

General function:: Involved in metal ion binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:: NT5C
Uniprot ID:: Q8TCD5
Molecular weight:: Not Available

Enzyme Details

5. 5'(3')-deoxyribonucleotidase, mitochondrial

General function:: Involved in phosphatase activity
Specific function:: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:: NT5M
Uniprot ID:: Q9NPB1
Molecular weight:: Not Available

Enzyme Details

6. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Enzyme Details

7. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Enzyme Details

8. Ectonucleoside triphosphate diphosphohydrolase 3

General function:: Involved in hydrolase activity
Specific function:: Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:: ENTPD3
Uniprot ID:: O75355
Molecular weight:: 59104.76

Enzyme Details

9. Inosine triphosphate pyrophosphatase

General function:: Involved in hydrolase activity
Specific function:: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Gene Name:: ITPA
Uniprot ID:: Q9BY32
Molecular weight:: 16833.23

Enzyme Details

10. Adenine phosphoribosyltransferase

General function:: Involved in adenine phosphoribosyltransferase activity
Specific function:: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Gene Name:: APRT
Uniprot ID:: P07741
Molecular weight:: 19607.535

Transporters

Enzyme Details

1. Cyclic nucleotide-gated cation channel alpha-3

General function:: Involved in ion channel activity
Specific function:: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones
Gene Name:: CNGA3
Uniprot ID:: Q16281
Molecular weight:: 78837.4

Only showing the first 10 proteins. There are 144 proteins in total.

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Showing Compound Card for Guanosine monophosphate (CDB004911)

Structure for CDB004911 (Guanosine monophosphate)

Enzymes

Transporters