| Identification |
|---|
| HMDB Protein ID
| CDBP00630 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein-glutamine gamma-glutamyltransferase E |
| Description
| Not Available |
| Synonyms
|
- Protein-glutamine gamma-glutamyltransferase E 27 kDa catalytic chain
- Protein-glutamine gamma-glutamyltransferase E 50 kDa non-catalytic chain
- TG(E)
- TGE
- TGase E
- TGase-3
- Transglutaminase E
- Transglutaminase-3
|
| Gene Name
| TGM3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein-glutamine gamma-glutamyltransferase activity |
| Specific Function
| Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
|
| GO Classification
|
| Biological Process |
| keratinocyte differentiation |
| protein tetramerization |
| peptide cross-linking |
| hair follicle morphogenesis |
| cell envelope organization |
| keratinization |
| Cellular Component |
| cytoplasm |
| extrinsic to internal side of plasma membrane |
| Function |
| transferase activity, transferring acyl groups |
| transferase activity, transferring amino-acyl groups |
| protein-glutamine gamma-glutamyltransferase activity |
| catalytic activity |
| transferase activity |
| Molecular Function |
| magnesium ion binding |
| GTPase activity |
| calcium ion binding |
| GTP binding |
| GDP binding |
| protein-glutamine gamma-glutamyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| post-translational protein modification |
| peptide cross-linking |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20q11.2 |
| SNPs
| TGM3 |
| Gene Sequence
|
>2082 bp
ATGGCTGCTCTAGGAGTCCAGAGTATCAACTGGCAGAAGGCCTTCAACCGACAAGCGCAT
CACACAGACAAGTTCTCCAGCCAGGAGCTCATCTTGCGGAGAGGCCAAAACTTCCAGGTC
TTAATGATCATGAACAAAGGCCTTGGCTCTAACGAAAGACTGGAGTTCATTGACACCACA
GGGCCTTACCCCTCAGAGTCGGCCATGACGAAGGCTGTGTTTCCACTCTCCAATGGCAGT
AGTGGTGGCTGGAGTGCGGTGCTTCAGGCCAGCAATGGCAATACTCTGACTATCAGCATC
TCCAGTCCTGCCAGCGCACCCATAGGACGGTACACAATGGCCCTCCAGATCTTCTCCCAG
GGCGGCATCTCCTCTGTGAAACTTGGGACGTTCATACTGCTTTTTAACCCCTGGCTGAAT
GTGGATAGCGTCTTTATGGGTAACCATGCTGAGAGAGAAGAGTATGTTCAGGAAGATGCC
GGCATCATCTTTGTGGGAAGCACAAACCGAATTGGCATGATTGGCTGGAACTTTGGACAG
TTTGAAGAAGACATTCTCAGCATCTGCCTCTCAATCTTGGATAGGAGTCTGAATTTCCGC
CGTGACGCTGCTACTGATGTGGCCAGCAGAAATGACCCCAAATACGTTGGCCGGGTGCTG
AGTGCCATGATCAATAGCAATGATGACAATGGTGTGCTTGCTGGGAATTGGAGCGGCACT
TACACCGGTGGCCGGGACCCAAGGAGCTGGGACGGCAGCGTGGAGATCCTCAAAAATTGG
AAAAAATCTGGCTTCAGCCCAGTCCGATATGGCCAGTGCTGGGTCTTTGCTGGGACCCTC
AACACAGCGCTGCGGTCTTTGGGGATTCCTTCCCGGGTGATCACCAACTTCAACTCAGCT
CATGACACAGACCGAAATCTCAGTGTGGATGTGTACTACGACCCCATGGGAAACCCCCTG
GACAAGGGTAGTGATAGCGTATGGAATTTCCATGTCTGGAATGAAGGCTGGTTTGTGAGG
TCTGACCTGGGCCCCCCGTACGGTGGATGGCAGGTGTTGGATGCTACCCCGCAGGAAAGA
AGCCAAGGGGTGTTCCAGTGCGGCCCCGCTTCGGTCATTGGTGTTCGAGAGGGTGATGTG
CAGCTGAACTTCGACATGCCCTTTATCTTCGCGGAGGTTAATGCCGACCGCATCACCTGG
CTGTACGACAACACCACTGGCAAACAGTGGAAGAATTCCGTGAACAGTCACACCATTGGC
AGGTACATCAGCACCAAGGCGGTGGGCAGCAATGCTCGCATGGACGTCACGGACAAGTAC
AAGTACCCAGAAGGCTCTGACCAGGAAAGACAAGTGTTCCAAAAGGCTTTGGGGAAACTT
AAACCCAACACGCCATTTGCCGCGACGTCTTCGATGGGTTTGGAAACAGAGGAACAGGAG
CCCAGCATCATCGGGAAGCTGAAGGTCGCTGGCATGCTGGCAGTAGGCAAAGAAGTCAAC
CTGGTCCTACTGCTCAAAAACCTGAGCAGGGATACGAAGACAGTGACAGTGAACATGACA
GCCTGGACCATCATCTACAACGGCACGCTTGTACATGAAGTGTGGAAGGACTCTGCCACA
ATGTCCCTGGACCCTGAGGAAGAGGCAGAACATCCCATAAAGATCTCGTACGCTCAGTAT
GAGAGGTACCTGAAGTCAGACAACATGATCCGGATCACAGCGGTGTGCAAGGTCCCAGAT
GAGTCTGAGGTGGTGGTGGAGCGGGACATCATCCTGGACAACCCCACCTTGACCCTGGAG
GTGCTGAACGAGGCTCGTGTGCGGAAGCCTGTGAACGTGCAGATGCTCTTCTCCAATCCA
CTGGATGAGCCGGTGAGGGACTGCGTGCTGATGGTGGAGGGAAGCGGCCTGCTGTTGGGT
AACCTGAAGATCGACGTGCCGACCCTAGGGCCCAAGGAGCGGTCCCGGGTCCGTTTTGAT
ATCCTGCCCTCCCGGAGTGGCACCAAGCAACTGCTCGCCGACTTCTCCTGCAACAAGTTC
CCTGCAATCAAGGCCATGTTGTCCATCGACGTAGCCGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 693 |
| Molecular Weight
| 76631.26 |
| Theoretical pI
| 5.864 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein-glutamine gamma-glutamyltransferase E
MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVST
GPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQ
GGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQ
FEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGT
YTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSA
HDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQER
SQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIG
RYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQE
PSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT
MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLE
VLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFD
ILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
|
| External Links |
|---|
| GenBank ID Protein
| 307504 |
| UniProtKB/Swiss-Prot ID
| Q08188 |
| UniProtKB/Swiss-Prot Entry Name
| TGM3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| L10386 |
| GeneCard ID
| TGM3 |
| GenAtlas ID
| TGM3 |
| HGNC ID
| HGNC:11779 |
| References |
|---|
| General References
| Not Available |