| Identification |
|---|
| HMDB Protein ID
| CDBP01518 |
| Secondary Accession Numbers
| Not Available |
| Name
| Disks large homolog 4 |
| Description
| Not Available |
| Synonyms
|
- PSD-95
- Postsynaptic density protein 95
- SAP-90
- SAP90
- Synapse-associated protein 90
|
| Gene Name
| DLG4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Cell junction
- Cell junction
- Cell junction
- synapse
- synapse
- synapse
- postsynaptic cell membrane
- postsynaptic density
- synaptosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17p13.1 |
| SNPs
| DLG4 |
| Gene Sequence
|
>2175 bp
ATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCC
CCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTC
AACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGGACCGAGGGGGAG
ATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCA
GGTGGCACTGACAACCCACACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATT
CCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCATCCTGTTTGTA
AATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCA
GGCTCCATCGTTCGCCTCTATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAG
ATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGGGCGTAGGGAAC
CAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCC
CACAAGGATGGGAGGTTGCAGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTA
GAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGATGTTGTCTAC
CTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATC
ACAACCTCTTATTCCCAGCACCTGGACAATGAGATCAGTCACAGCAGCTACCTGGGCACC
GACTACCCCACAGCCATGACCCCCACTTCCCCTCGGCGCTACTCTCCAGTGGCCAAGGAC
CTGCTCGGGGAGGAAGACATTCCCCGAGAACCGAGGCGAATTGTGATCCACCGGGGCTCC
ACGGGCCTGGGCTTCAACATCGTGGGTGGCGAGGACGGTGAAGGCATCTTCATCTCCTTT
ATCCTGGCCGGGGGCCCTGCAGACCTCAGTGGGGAGCTGCGGAAGGGGGACCAGATCCTG
TCGGTCAACGGTGTGGACCTCCGAAATGCCAGCCATGAGCAGGCTGCCATTGCCCTGAAG
AATGCGGGTCAGACGGTCACGATCATCGCTCAGTATAAACCAGAAGAGTACAGCCGATTC
GAGGCCAAGATCCACGACCTTCGGGAACAGCTCATGAACAGCAGCCTGGGCTCAGGGACT
GCGTCCCTGCGGAGCAACCCCAAAAGGGGTTTCTACATCAGGGCCCTGTTTGATTACGAC
AAGACCAAGGACTGCGGCTTCCTGAGCCAGGCCCTGAGCTTCCGCTTTGGGGATGTGCTG
CATGTCATCGATGCTAGTGATGAGGAGTGGTGGCAGGCACGGCGGGTCCACTCTGACAGT
GAGACCGACGACATTGGGTTCATCCCCAGCAAACGGCGGGTTGAGCGACGAGAGTGGTCA
AGGTTAAAGGCCAAGGACTGGGGCTCCAGCTCTGGATCGCAGGGTCGAGAAGACTCGGTT
CTGAGCTACGAGACAGTGACGCAGATGGAAGTGCACTATGCTCGCCCCATCATCATCCTT
GGGCCCACCAAGGACCGCGCCAACGATGATCTTCTCTCCGAGTTCCCCGACAAGTTTGGA
TCCTGTGTTCCCCATACGACACGGCCCAAGCGGGAGTATGAGATAGATGGCCGGGATTAC
CACTTTGTGTCGTCCCGGGAGAAAATGGAGAAGGACATTCAGGCGCACAAGTTCATTGAG
GCCGGCCAGTACAACAGCCACCTCTATGGGACCAGCGTCCAGTCCGTGCGAGAGGTGGCA
GAGCAGGGGAAGCACTGCATCCTCGATGTCTCGGCCAATGCCGTGCGGCGGCTGCAGGCG
GCCCACCTGCACCCCATCGCCATCTTCATCCGCCCCCGCTCCCTGGAGAATGTGCTAGAG
ATTAACAAGCGGATCACAGAGGAGCAAGCCCGCAAAGCCTTCGACAGAGCCACCAAGCTG
GAGCAGGAGTTCACAGAGTGCTTCTCAGCCATCGTGGAGGGTGACAGCTTTGAGGAGATC
TACCACAAGGTGAAGCGTGTCATCGAGGACCTCTCAGGCCCCTACATCTGGGTTCCAGCC
CGAGAGAGACTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 724 |
| Molecular Weight
| 80494.6 |
| Theoretical pI
| 5.71 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Disks large homolog 4
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGE
MEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV
NEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN
QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVY
LKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKD
LLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQIL
SVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGT
ASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDS
ETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIIL
GPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIE
AGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLE
INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPA
RERL
|
| External Links |
|---|
| GenBank ID Protein
| 221039688 |
| UniProtKB/Swiss-Prot ID
| P78352 |
| UniProtKB/Swiss-Prot Entry Name
| DLG4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK293835 |
| GeneCard ID
| DLG4 |
| GenAtlas ID
| DLG4 |
| HGNC ID
| HGNC:2903 |
| References |
|---|
| General References
| Not Available |