Cannabis Compound Database: Showing Compound Card for Glutathione (CDB004805)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (50)transporters (5) Show 60 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:38:34 UTC

Updated at

2020-12-07 19:10:59 UTC

CannabisDB ID

CDB004805

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Glutathione

Description

Glutathione, also known as GSH or agifutol S, belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another. Glutathione is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. Glutathione is a very strong basic compound (based on its pKa). A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine. Glutathione exists in all living species, ranging from bacteria to humans. Within humans, glutathione participates in a number of enzymatic reactions. In particular, leukotriene A4 and glutathione can be converted into leukotriene C4 through its interaction with the enzyme leukotriene C4 synthase. In addition, 15(S)-hpete and glutathione can be converted into 15(S)-hete and oxidized glutathione through its interaction with the enzyme glutathione peroxidase 1. In humans, glutathione is involved in mefenamic acid action pathway. Outside of the human body, Glutathione is found, on average, in the highest concentration within a few different foods, such as purslanes, spinachs, and corns. Glutathione has also been detected, but not quantified in, several different foods, such as yautia, coconuts, common salsifies, pigeon pea, and ohelo berries. This could make glutathione a potential biomarker for the consumption of these foods. Glutathione is a potentially toxic compound. Glutathione is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
5-L-Glutamyl-L-cysteinylglycine	ChEBI
gamma-L-Glutamyl-L-cysteinyl-glycine	ChEBI
Glutathione-SH	ChEBI
GSH	ChEBI
N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine	ChEBI
Reduced glutathione	ChEBI
Poly(gamma-glutamylcysteine)glycine	Kegg
(gamma-Glutamylcysteine)N-glycine	Kegg
Tathion	Kegg
g-L-Glutamyl-L-cysteinyl-glycine	Generator
Γ-L-glutamyl-L-cysteinyl-glycine	Generator
N-(N-g-L-Glutamyl-L-cysteinyl)glycine	Generator
N-(N-Γ-L-glutamyl-L-cysteinyl)glycine	Generator
Poly(g-glutamylcysteine)glycine	Generator
Poly(γ-glutamylcysteine)glycine	Generator
(g-Glutamylcysteine)N-glycine	Generator
(Γ-glutamylcysteine)N-glycine	Generator
Agifutol S	HMDB
Bakezyme RX	HMDB
Copren	HMDB
Deltathione	HMDB
gamma-Glutamylcysteinylglycine	HMDB
gamma-L-Glutamyl-L-cysteinylglycine	HMDB
Glutathion	HMDB
Glutathione red	HMDB
Glutathione reduced	HMDB
Glutatiol	HMDB
Glutatione	HMDB
Glutide	HMDB
Glutinal	HMDB
Isethion	HMDB
L-g-Glutamyl-L-cysteinyl-glycine	HMDB
L-gamma-Glutamyl-L-cysteinyl-glycine	HMDB
L-gamma-Glutamyl-L-cysteinylglycine	HMDB
L-Glutamyl-L-cysteinylglycine	HMDB
L-Glutathione	HMDB
L-Glutathione reduce	HMDB
Ledac	HMDB
Neuthion	HMDB
Red. glutathione	HMDB
Tathione	HMDB
Triptide	HMDB
Glutathione, reduced	HMDB
gamma L Glu L cys gly	HMDB
gamma-L-Glu-L-cys-gly	HMDB
gamma L Glutamyl L cysteinylglycine	HMDB

Chemical Formula

C₁₀H₁₇N₃O₆S

Average Molecular Weight

307.32

Monoisotopic Molecular Weight

307.0838

IUPAC Name

(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid

Traditional Name

glutathione

CAS Registry Number

70-18-8

SMILES

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

InChI Identifier

InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

InChI Key

RWSXRVCMGQZWBV-WDSKDSINSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Peptides

Alternative Parents

Substituents

Alpha peptide
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alpha-amino acid
Alpha-amino acid or derivatives
L-alpha-amino acid
Dicarboxylic acid or derivatives
Fatty acid
Amino acid or derivatives
Amino acid
Alkylthiol
Carboximidic acid
Carboximidic acid derivative
Carboxylic acid
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Hydrocarbon derivative
Primary aliphatic amine
Organic oxide
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Amine
Organonitrogen compound
Organooxygen compound
Organosulfur compound
Organopnictogen compound
Primary amine
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

thiol (CHEBI:16856 )
L-cysteine derivative (CHEBI:16856 )
tripeptide (CHEBI:16856 )
Coenzymes (C00051 )

Ontology

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Industrial application:

Personal care products

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	195 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	292.5 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-2.7	ALOGPS
logP	-4.9	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	1.94	ChemAxon
pKa (Strongest Basic)	9.22	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	158.82 Å²	ChemAxon
Rotatable Bond Count	9	ChemAxon
Refractivity	69.11 m³·mol⁻¹	ChemAxon
Polarizability	29.11 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Glutathione, x TMS, GC-MS Spectrum	splash10-0a4i-0900000000-5841845f736f9a667622	Spectrum
GC-MS	Glutathione, x TMS, GC-MS Spectrum	splash10-0a4i-0900000000-bdecde153761cb67852e	Spectrum
GC-MS	Glutathione, non-derivatized, GC-MS Spectrum	splash10-0a4i-0900000000-5841845f736f9a667622	Spectrum
GC-MS	Glutathione, non-derivatized, GC-MS Spectrum	splash10-0a4i-0900000000-bdecde153761cb67852e	Spectrum
GC-MS	Glutathione, non-derivatized, GC-MS Spectrum	splash10-0a4i-1910000000-52bc43dd913b68d74f84	Spectrum
GC-MS	Glutathione, non-derivatized, GC-MS Spectrum	splash10-08fs-3960000000-63ce34def2ae94b95515	Spectrum
GC-MS	Glutathione, non-derivatized, GC-MS Spectrum	splash10-0pb9-0921000000-88168b0a9f5fc5fead3f	Spectrum
Predicted GC-MS	Glutathione, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0006-7890000000-5853006f66d946dd3d2e	Spectrum
Predicted GC-MS	Glutathione, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0596-9112300000-e82cf72540c283d8e323	Spectrum
Predicted GC-MS	Glutathione, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_1_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Glutathione, TMS_2_10, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-004i-3795000000-d019cd7dcbad1f8a9e78	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-003r-9400000000-a83bf6292d41988256e3	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-001i-9000000000-305a92f8a9ffea58fa0e	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0009000000-e950bfc5867b391c6960	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0910000000-83f6c079d1112e74ecf4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-003r-0910000000-5b243cf8bd357ab270b1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0009000000-29ef335479f56b620d88	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0009001000-d1f5986166efa523d024	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-056s-0495300000-dba7be381fd1ef776527	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0920000000-de5b8a5a377324599b39	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-053r-0007920000-7500cef211e48c8ea244	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0119003000-4eb7ed4e2a4cf6a83c66	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0uki-0290000000-6893386899c6eed6a1a6	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-05g0-0190000000-cacc2de4ab18ed59798b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0009000000-6b4268add43ab66ef015	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-08fr-0015009000-a01bdc13a34d6ce8416f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0uki-0290000000-ea94ec8247b4e025adbe	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0039210000-e1f721157a9ea89959d6	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a59-0039210000-35ce450ea95922abf0e1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0a4i-0009000000-9b01fba547d1fcde113a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0006-0952000000-4a2a42699cf4aab2c559	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-002f-2900000000-bd9ba27b48b1322b7618	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-004m-5900000000-cc7184d5bba50e6e49d0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0a4i-9200000000-aecd0eb18a10c3ffb7ab	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0729-4492000000-78a928563adf9038ba59	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glutamate Metabolism
Glutathione Metabolism
Pyruvaldehyde Degradation		Not Available
Arachidonic Acid Metabolism
Glutathione Synthetase Deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Prostaglandin E synthase	PTGES	9q34.3	O14684	details
Glutathione reductase, mitochondrial	GSR	8p21.1	P00390	details
Peroxiredoxin-6	PRDX6	1q25.1	P30041	details
Lactoylglutathione lyase	GLO1	6p21.3-p21.1	Q04760	details
S-formylglutathione hydrolase	ESD	13q14.1-q14.2	P10768	details
Gamma-glutamyltranspeptidase 1	GGT1	22q11.23	P19440	details
Gamma-glutamyltransferase 7	GGT7	20q11.22	Q9UJ14	details
Glutathione synthetase	GSS	20q11.2	P48637	details
Leukotriene C4 synthase	LTC4S	5q35	Q16873	details
Glutathione S-transferase Mu 2	GSTM2	1p13.3	P28161	details
Glutathione peroxidase 7	GPX7	1p32	Q96SL4	details
Epididymal secretory glutathione peroxidase	GPX5	6p22.1	O75715	details
Glutathione S-transferase Mu 1	GSTM1	1p13.3	P09488	details
Hydroxyacylglutathione hydrolase, mitochondrial	HAGH	16p13.3	Q16775	details
Glutathione S-transferase kappa 1	GSTK1	7q34	Q9Y2Q3	details
Microsomal glutathione S-transferase 3	MGST3	1q23	O14880	details
Glutathione S-transferase Mu 3	GSTM3	1p13.3	P21266	details
Glutathione S-transferase A1	GSTA1	6p12.1	P08263	details
Maleylacetoacetate isomerase	GSTZ1	14q24.3	O43708	details
Microsomal glutathione S-transferase 1	MGST1	12p12.3-p12.1	P10620	details
Glutathione S-transferase Mu 4	GSTM4	1p13.3	Q03013	details
Glutathione S-transferase Mu 5	GSTM5	1p13.3	P46439	details
Microsomal glutathione S-transferase 2	MGST2	4q28.3	Q99735	details
Glutathione S-transferase omega-1	GSTO1	10q25.1	P78417	details
Glutathione S-transferase A5	GSTA5	6p12.2	Q7RTV2	details
Glutathione S-transferase A2	GSTA2	6p12.1	P09210	details
Glutathione peroxidase 6	GPX6	6p22.1	P59796	details
Glutathione S-transferase A3	GSTA3	6p12.1	Q16772	details
Glutathione S-transferase A4	GSTA4	6p12.1	O15217	details
Glutathione peroxidase 1	GPX1	3p21.3	P07203	details
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	19p13.3	P36969	details
Glutathione peroxidase 3	GPX3	5q23	P22352	details
Glutathione S-transferase omega-2	GSTO2	10q25.1	Q9H4Y5	details
Glutathione S-transferase theta-1	GSTT1	22q11.23	P30711	details
Glutathione peroxidase 2	GPX2	14q24.1	P18283	details
Glutathione S-transferase P	GSTP1	11q13	P09211	details
Hematopoietic prostaglandin D synthase	HPGDS	4q22.3	O60760	details
Glutaredoxin-1	GLRX	5q14	P35754	details
Glutaredoxin-2, mitochondrial	GLRX2	1q31.2-q31.3	Q9NS18	details
Hydroxyacylglutathione hydrolase-like protein	HAGHL		Q6PII5	details
Gamma-glutamyltransferase 6	GGT6	17p13.2	Q6P531	details
Thioredoxin domain-containing protein 12	TXNDC12	1p32.3	O95881	details
GGT7 protein	GGT7	20q11.22	A0PJJ9	details
Gamma-glutamyltransferase 5	GGT5	22q11.23	P36269	details
Glutathione S-transferase theta-2	GSTT2		P0CG29	details
Gamma-glutamyltranspeptidase 2	GGT2		P36268	details
Putative gamma-glutamyltranspeptidase 3	GGT3P		A6NGU5	details
Probable glutathione peroxidase 8	GPX8	5q11.2	Q8TED1	details
Glutathione S-transferase theta-2B	GSTT2B	22q11.23	P0CG30	details
Glutathione S-transferase theta-4	GSTT4		A8MPT4	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Canalicular multispecific organic anion transporter 1	ABCC2	10q24	Q92887	details
Multidrug resistance-associated protein 1	ABCC1	16p13.1	P33527	details
Canalicular multispecific organic anion transporter 2	ABCC3	17q22	O15438	details
Multidrug resistance-associated protein 4	ABCC4	13q32	O15439	details
Multidrug resistance-associated protein 5	ABCC5	3q27	O15440	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Lactoylglutathione lyase	GLO1	6p21.3-p21.1	Q04760	details
Hydroxyacylglutathione hydrolase, mitochondrial	HAGH	16p13.3	Q16775	details
Hydroxyacylglutathione hydrolase-like protein	HAGHL		Q6PII5	details

Receptors

Not Available

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Lactoylglutathione lyase	GLO1	6p21.3-p21.1	Q04760	details
Glutathione peroxidase 3	GPX3	5q23	P22352	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000125

DrugBank ID

DB00143

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

124886

PDB ID

Not Available

ChEBI ID

16856

References

General References

Not Available

Only showing the first 10 proteins. There are 60 proteins in total.

Show All

Enzymes

Enzyme Details

1. Prostaglandin E synthase

General function:: Involved in prostaglandin-E synthase activity
Specific function:: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
Gene Name:: PTGES
Uniprot ID:: O14684
Molecular weight:: 17102.135

Enzyme Details

2. Glutathione reductase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Maintains high levels of reduced glutathione in the cytosol.
Gene Name:: GSR
Uniprot ID:: P00390
Molecular weight:: 56256.565

Enzyme Details

3. Peroxiredoxin-6

General function:: Involved in antioxidant activity
Specific function:: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
Gene Name:: PRDX6
Uniprot ID:: P30041
Molecular weight:: 25034.715

Enzyme Details

4. Lactoylglutathione lyase

General function:: Involved in lactoylglutathione lyase activity
Specific function:: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.
Gene Name:: GLO1
Uniprot ID:: Q04760
Molecular weight:: 20777.515

Enzyme Details

5. S-formylglutathione hydrolase

General function:: Involved in carboxylesterase activity
Specific function:: Serine hydrolase involved in the detoxification of formaldehyde.
Gene Name:: ESD
Uniprot ID:: P10768
Molecular weight:: 31462.545

Enzyme Details

6. Gamma-glutamyltranspeptidase 1

General function:: Involved in gamma-glutamyltransferase activity
Specific function:: Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.
Gene Name:: GGT1
Uniprot ID:: P19440
Molecular weight:: 61409.67

Enzyme Details

7. Gamma-glutamyltransferase 7

General function:: Involved in gamma-glutamyltransferase activity
Specific function:: Cleaves glutathione conjugates (By similarity).
Gene Name:: GGT7
Uniprot ID:: Q9UJ14
Molecular weight:: 70466.015

Enzyme Details

8. Glutathione synthetase

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: GSS
Uniprot ID:: P48637
Molecular weight:: 52384.325

Enzyme Details

9. Leukotriene C4 synthase

General function:: Involved in enzyme activator activity
Specific function:: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
Gene Name:: LTC4S
Uniprot ID:: Q16873
Molecular weight:: 16566.465

Enzyme Details

10. Glutathione S-transferase Mu 2

General function:: Involved in glutathione transferase activity
Specific function:: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Gene Name:: GSTM2
Uniprot ID:: P28161
Molecular weight:: 25744.395

Transporters

Enzyme Details

1. Canalicular multispecific organic anion transporter 1

General function:: Involved in ATP binding
Specific function:: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter
Gene Name:: ABCC2
Uniprot ID:: Q92887
Molecular weight:: 174205.6

Enzyme Details

2. Multidrug resistance-associated protein 1

General function:: Involved in ATP binding
Specific function:: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency
Gene Name:: ABCC1
Uniprot ID:: P33527
Molecular weight:: 171589.5

Enzyme Details

3. Canalicular multispecific organic anion transporter 2

General function:: Involved in ATP binding
Specific function:: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes
Gene Name:: ABCC3
Uniprot ID:: O15438
Molecular weight:: 169341.1

Enzyme Details

4. Multidrug resistance-associated protein 4

General function:: Involved in ATP binding
Specific function:: May be an organic anion pump relevant to cellular detoxification
Gene Name:: ABCC4
Uniprot ID:: O15439
Molecular weight:: 149525.3

Enzyme Details

5. Multidrug resistance-associated protein 5

General function:: Involved in ATP binding
Specific function:: Acts as a multispecific organic anion pump which can transport nucleotide analogs
Gene Name:: ABCC5
Uniprot ID:: O15440
Molecular weight:: 160658.8

Only showing the first 10 proteins. There are 60 proteins in total.

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Showing Compound Card for Glutathione (CDB004805)

Structure for CDB004805 (Glutathione)

Enzymes

Transporters