| Identification |
|---|
| HMDB Protein ID
| CDBP00759 |
| Secondary Accession Numbers
| Not Available |
| Name
| Microsomal glutathione S-transferase 3 |
| Description
| Not Available |
| Synonyms
|
- Microsomal GST-3
- Microsomal GST-III
|
| Gene Name
| MGST3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Also functions as a glutathione peroxidase.
|
| GO Classification
|
| Biological Process |
| signal transduction |
| xenobiotic metabolic process |
| glutathione biosynthetic process |
| lipid metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| nuclear envelope |
| integral to membrane |
| Molecular Function |
| glutathione peroxidase activity |
| glutathione transferase activity |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
- Microsome membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q23 |
| SNPs
| MGST3 |
| Gene Sequence
|
>459 bp
ATGGCTGTCCTCTCTAAGGAATATGGTTTTGTGCTTCTAACTGGTGCTGCCAGCTTTATA
ATGGTGGCCCACCTAGCCATCAATGTTTCCAAGGCCCGCAAGAAGTACAAAGTGGAGTAT
CCTATCATGTACAGCACGGACCCTGAAAATGGGCACATCTTCAACTGCATTCAGCGAGCC
CACCAGAACACGTTGGAAGTGTATCCTCCCTTCTTATTTTTTCTAGCTGTTGGAGGTGTT
TACCACCCGCGTATAGCTTCTGGCCTGGGCTTGGCCTGGATTGTTGGACGAGTTCTTTAT
GCTTATGGCTATTACACGGGAGAACCCAGCAAGCGTAGTCGAGGAGCCCTGGGGTCCATC
GCCCTCCTGGGCTTGGTGGGCACAACTGTGTGCTCTGCTTTCCAGCATCTTGGTTGGGTT
AAAAGTGGCTTGGGCAGTGGACCCAAATGCTGCCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 152 |
| Molecular Weight
| 16516.185 |
| Theoretical pI
| 9.382 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Microsomal glutathione S-transferase 3
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA
HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI
ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
|
| External Links |
|---|
| GenBank ID Protein
| 2583081 |
| UniProtKB/Swiss-Prot ID
| O14880 |
| UniProtKB/Swiss-Prot Entry Name
| MGST3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF026977 |
| GeneCard ID
| MGST3 |
| GenAtlas ID
| MGST3 |
| HGNC ID
| HGNC:7064 |
| References |
|---|
| General References
| Not Available |