| Identification |
|---|
| HMDB Protein ID
| CDBP00767 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutathione S-transferase omega-1 |
| Description
| Not Available |
| Synonyms
|
- GSTO-1
- Glutathione S-transferase omega 1-1
- Glutathione-dependent dehydroascorbate reductase
- Monomethylarsonic acid reductase
- S-(Phenacyl)glutathione reductase
- GSTO 1-1
- MMA(V) reductase
- SPG-R
|
| Gene Name
| GSTO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
|
| GO Classification
|
| Biological Process |
| L-ascorbic acid metabolic process |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| negative regulation of ryanodine-sensitive calcium-release channel activity |
| positive regulation of ryanodine-sensitive calcium-release channel activity |
| L-ascorbic acid biosynthetic process |
| xenobiotic catabolic process |
| cellular response to arsenic-containing substance |
| Cellular Component |
| cytosol |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| glutathione transferase activity |
| Molecular Function |
| glutathione dehydrogenase (ascorbate) activity |
| methylarsonate reductase activity |
| glutathione transferase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q25.1 |
| SNPs
| GSTO1 |
| Gene Sequence
|
>726 bp
ATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCG
GAGGGCTCGATCCGCATCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTA
GTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGCCT
GAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGT
CAGCTGATCTACGAGTCTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAG
AAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGTTT
TCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCT
GGCCTAAAAGAAGAATTTCGTAAAGAATTTACCAAGCTAGAGGAGGTTCTGACTAATAAG
AAGACGACCTTCTTTGGTGGCAATTCTATCTCTATGATTGATTACCTCATCTGGCCCTGG
TTTGAACGGCTGGAAGCAATGAAGTTAAATGAGTGTGTAGACCACACTCCAAAACTGAAA
CTGTGGATGGCAGCCATGAAGGAAGATCCCACAGTCTCAGCCCTGCTTACTAGTGAGAAA
GACTGGCAAGGTTTCCTAGAGCTCTACTTACAGAACAGCCCTGAGGCCTGTGACTATGGG
CTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 241 |
| Molecular Weight
| 27565.6 |
| Theoretical pI
| 6.589 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione S-transferase omega-1
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKP
EWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELF
SKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPW
FERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYG
L
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P78417 |
| UniProtKB/Swiss-Prot Entry Name
| GSTO1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U90313 |
| GeneCard ID
| GSTO1 |
| GenAtlas ID
| GSTO1 |
| HGNC ID
| HGNC:13312 |
| References |
|---|
| General References
| Not Available |