| Identification |
|---|
| HMDB Protein ID
| CDBP01463 |
| Secondary Accession Numbers
| Not Available |
| Name
| Hematopoietic prostaglandin D synthase |
| Description
| Not Available |
| Synonyms
|
- GST class-sigma
- Glutathione S-transferase
- Glutathione-dependent PGD synthase
- Glutathione-requiring prostaglandin D synthase
- H-PGDS
- Prostaglandin-H2 D-isomerase
|
| Gene Name
| HPGDS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
|
| GO Classification
|
| Biological Process |
| locomotory behavior |
| signal transduction |
| prostaglandin metabolic process |
| prostaglandin biosynthetic process |
| Cellular Component |
| cytoplasm |
| nucleus |
| Molecular Function |
| magnesium ion binding |
| glutathione transferase activity |
| calcium ion binding |
| prostaglandin-D synthase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG |
|---|
| Arachidonic Acid Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q22.3 |
| SNPs
| HPGDS |
| Gene Sequence
|
>600 bp
ATGCCAAACTACAAACTCACTTATTTTAATATGAGGGGGAGAGCAGAAATTATTCGTTAC
ATATTTGCTTATTTGGACATACAGTATGAAGACCACAGAATAGAACAAGCTGACTGGCCT
GAAATCAAATCAACTCTCCCATTTGGAAAAATCCCCATTTTGGAAGTTGATGGACTTACT
CTTCACCAGAGCCTAGCAATAGCAAGATATTTGACCAAAAACACAGATTTGGCTGGAAAC
ACAGAAATGGAACAATGTCATGTTGATGCTATTGTGGACACTCTGGATGATTTCATGTCA
TGTTTTCCTTGGGCAGAGAAAAAGCAAGATGTGAAAGAGCAGATGTTCAATGAGCTGCTC
ACGTATAATGCGCCTCATCTTATGCAAGACTTGGACACATATTTAGGGGGGAGAGAATGG
CTTATTGGTAACTCTGTAACTTGGGCAGACTTCTACTGGGAGATTTGCAGTACCACACTT
TTGGTCTTTAAGCCTGACCTGTTAGACAACCATCCAAGGCTGGTGACTTTACGGAAGAAA
GTCCAAGCCATTCCTGCCGTCGCTAACTGGATAAAACGAAGGCCCCAAACCAAACTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 199 |
| Molecular Weight
| 23343.65 |
| Theoretical pI
| 5.849 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hematopoietic prostaglandin D synthase
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O60760 |
| UniProtKB/Swiss-Prot Entry Name
| HPGDS_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| D82073 |
| GeneCard ID
| HPGDS |
| GenAtlas ID
| HPGDS |
| HGNC ID
| HGNC:17890 |
| References |
|---|
| General References
| Not Available |