| Identification |
|---|
| HMDB Protein ID
| CDBP00760 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutathione S-transferase Mu 3 |
| Description
| Not Available |
| Synonyms
|
- GST class-mu 3
- GSTM3-3
- hGSTM3-3
|
| Gene Name
| GSTM3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
|
| GO Classification
|
| Biological Process |
| glutathione metabolic process |
| xenobiotic catabolic process |
| response to estrogen stimulus |
| cellular detoxification of nitrogen compound |
| nitrobenzene metabolic process |
| establishment of blood-nerve barrier |
| Cellular Component |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| glutathione transferase activity |
| Molecular Function |
| glutathione binding |
| glutathione transferase activity |
| protein homodimerization activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p13.3 |
| SNPs
| GSTM3 |
| Gene Sequence
|
>678 bp
ATGTCGTGCGAGTCGTCTATGGTTCTCGGGTACTGGGATATTCGTGGGCTGGCGCACGCC
ATCCGCCTGCTCCTGGAGTTCACGGATACCTCTTATGAGGAGAAACGGTACACGTGCGGG
GAAGCTCCTGACTATGATCGAAGCCAATGGCTGGATGTGAAATTCAAGCTAGACCTGGAC
TTTCCTAATCTGCCCTACCTCCTGGATGGGAAGAACAAGATCACCCAGAGCAATGCCATC
TTGCGCTACATCGCTCGCAAGCACAACATGTGTGGTGAGACTGAAGAAGAAAAGATTCGA
GTGGACATCATAGAGAACCAAGTAATGGATTTCCGCACACAACTGATAAGGCTCTGTTAC
AGCTCTGACCACGAAAAACTGAAGCCTCAGTACTTGGAAGAGCTACCTGGACAACTGAAA
CAATTCTCCATGTTTCTGTGGAAATTCTCATGGTTTGCCGGGGAAAAGCTCACCTTTGTG
GATTTTCTCACCTATGATATCTTGGATCAGAACCGTATATTTGACCCCAAGTGCCTGGAT
GAGTTCCCAAACCTGAAGGCTTTCATGTGCCGTTTTGAGGCTTTGGAGAAAATCGCTGCC
TACTTACAGTCTGATCAGTTCTGCAAGATGCCCATCAACAACAAGATGGCCCAGTGGGGC
AACAAGCCTGTATGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 225 |
| Molecular Weight
| 26559.32 |
| Theoretical pI
| 5.538 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione S-transferase Mu 3
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
|
| External Links |
|---|
| GenBank ID Protein
| 306820 |
| UniProtKB/Swiss-Prot ID
| P21266 |
| UniProtKB/Swiss-Prot Entry Name
| GSTM3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J05459 |
| GeneCard ID
| GSTM3 |
| GenAtlas ID
| GSTM3 |
| HGNC ID
| HGNC:4635 |
| References |
|---|
| General References
| Not Available |