Showing Protein Leukotriene C4 synthase (CDBP00752)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP00752
Secondary Accession Numbers Not Available
Name Leukotriene C4 synthase
Description Not Available
Synonyms
  1. LTC4 synthase
  2. Leukotriene-C(4) synthase
Gene Name LTC4S
Protein Type Enzyme
Biological Properties
General Function Involved in enzyme activator activity
Specific Function Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
GO Classification
Biological Process
glutathione biosynthetic process
leukotriene biosynthetic process
response to axon injury
response to inorganic substance
response to drug
cellular response to lipopolysaccharide
cellular response to vitamin A
leukotriene metabolic process
positive regulation of catalytic activity
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
nuclear envelope
nuclear outer membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
enzyme regulator activity
enzyme activator activity
Molecular Function
glutathione transferase activity
lipid binding
enzyme activator activity
leukotriene-C4 synthase activity
glutathione peroxidase activity
glutathione binding
Process
metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
leukotriene metabolic process
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
  3. Multi-pass membrane protein
  4. Nucleus outer membrane
Pathways
Gene Properties
Chromosome Location 5
Locus 5q35
SNPs LTC4S
Gene Sequence 
>453 bp
ATGAAGGACGAGGTAGCTCTACTGGCTGCTGTCACCCTCCTGGGAGTCCTGCTGCAAGCC
TACTTCTCCCTGCAGGTGATCTCGGCGCGCAGGGCCTTCCGCGTGTCGCCGCCGCTCACC
ACCGGCCCACCCGAGTTCGAGCGCGTCTACCGAGCCCAGGTGAACTGCAGCGAGTACTTC
CCGCTGTTCCTCGCCACGCTCTGGGTCGCCGGCATCTTCTTTCATGAAGGGGCGGCGGCC
CTGTGCGGCCTGGTCTACCTGTTCGCGCGCCTCCGCTACTTCCAGGGCTACGCGCGCTCC
GCGCAGCTCAGGCTGGCACCGCTGTACGCGAGCGCGCGCGCCCTCTGGCTGCTGGTGGCG
CTGGCTGCGCTCGGCCTGCTCGCCCACTTCCTCCCGGCCGCGCTGCGCGCCGCGCTCCTC
GGACGGCTCCGGACGCTGCTGCCGTGGGCCTGA
Protein Properties
Number of Residues 150
Molecular Weight 16566.465
Theoretical pI 10.187
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Leukotriene C4 synthase
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA
LAALGLLAHFLPAALRAALLGRLRTLLPWA
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q16873
UniProtKB/Swiss-Prot Entry Name LTC4S_HUMAN
PDB IDs
GenBank Gene ID U09353
GeneCard ID LTC4S
GenAtlas ID LTC4S
HGNC ID HGNC:6719
References
General References Not Available