| Identification |
|---|
| HMDB Protein ID
| CDBP02458 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutaredoxin-2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| GLRX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release |
| GO Classification
|
| Function |
| catalytic activity |
| electron carrier activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| disulfide oxidoreductase activity |
| protein disulfide oxidoreductase activity |
| oxidoreductase activity |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Isoform 2:Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q31.2-q31.3 |
| SNPs
| GLRX2 |
| Gene Sequence
|
>495 bp
ATGATTTGGCGCCGCGCGGCGCTGGCGGGGACGCGGCTGGTTTGGAGCAGGAGCGGCTCG
GCAGGCTGGCTTGACAGGGCGGCGGGAGCTGCGGGAGCTGCGGCAGCTGCGGCCTCTGGG
ATGGAGAGCAATACATCATCATCTTTGGAGAATTTAGCGACGGCGCCTGTGAACCAGATC
CAAGAAACAATTTCTGATAATTGTGTGGTGATTTTCTCAAAAACATCCTGTTCTTACTGT
ACAATGGCAAAAAAGCTTTTCCATGACATGAATGTTAACTATAAAGTGGTGGAACTGGAC
CTGCTTGAATATGGAAACCAGTTCCAAGATGCTCTTTACAAAATGACTGGTGAAAGAACT
GTTCCAAGAATATTTGTCAATGGTACTTTTATTGGAGGTGCAACTGACACTCATAGGCTT
CACAAAGAAGGAAAATTGCTCCCACTAGTTCATCAGTGTTATTTAAAAAAAAGTAAGAGG
AAAGAATTTCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 164 |
| Molecular Weight
| 18051.5 |
| Theoretical pI
| 9.49 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Glutaredoxin-2, mitochondrial
MIWRRAALAGTRLVWSRSGSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQI
QETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERT
VPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKEFQ
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9NS18 |
| UniProtKB/Swiss-Prot Entry Name
| GLRX2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF132495 |
| GeneCard ID
| GLRX2 |
| GenAtlas ID
| GLRX2 |
| HGNC ID
| HGNC:16065 |
| References |
|---|
| General References
| Not Available |