Identification |
HMDB Protein ID
| CDBP00482 |
Secondary Accession Numbers
| Not Available |
Name
| S-formylglutathione hydrolase |
Description
| Not Available |
Synonyms
|
- Esterase D
- FGH
- Methylumbelliferyl-acetate deacetylase
|
Gene Name
| ESD |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in carboxylesterase activity |
Specific Function
| Serine hydrolase involved in the detoxification of formaldehyde.
|
GO Classification
|
Biological Process |
formaldehyde catabolic process |
Cellular Component |
Golgi apparatus |
nucleus |
cytoplasmic membrane-bounded vesicle |
Component |
cytoplasmic vesicle |
cytoplasmic membrane-bounded vesicle |
organelle |
vesicle |
Function |
carboxylesterase activity |
thiolester hydrolase activity |
s-formylglutathione hydrolase activity |
hydrolase activity, acting on ester bonds |
catalytic activity |
hydrolase activity |
Molecular Function |
carboxylesterase activity |
methylumbelliferyl-acetate deacetylase activity |
S-formylglutathione hydrolase activity |
|
Cellular Location
|
- Cytoplasm
- Cytoplasmic vesicle
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 13 |
Locus
| 13q14.1-q14.2 |
SNPs
| ESD |
Gene Sequence
|
>849 bp
ATGGCATTGAAGCAGATTTCCAGCAACAAGTGCTTTGGGGGATTGCAGAAAGTTTTTGAA
CATGACAGTGTTGAACTAAACTGCAAAATGAAATTTGCTGTCTACTTACCACCAAAGGCA
GAAACAGGAAAGTGCCCTGCACTGTATTGGCTCTCAGGTTTAACTTGCACAGAGCAAAAT
TTTATATCAAAATCTGGTTATCATCAGTCTGCTTCAGAACATGGTCTTGTTGTCATTGCT
CCAGATACCAGCCCTCGTGGCTGCAATATTAAAGGTGAAGATGAGAGCTGGGACTTTGGC
ACTGGTGCTGGATTTTATGTTGATGCCACTGAAGATCCTTGGAAAACCAACTACAGAATG
TACTCTTATGTCACAGAGGAGCTTCCCCAACTCATAAATGCCAATTTTCCAGTGGATCCC
CAAAGGATGTCTATTTTTGGCCACTCCATGGGAGGTCATGGAGCTCTGATCTGTGCTTTG
AAAAATCCTGGAAAATACAAATCTGTGTCAGCATTTGCTCCAATTTGCAACCCTGTACTC
TGTCCCTGGGGCAAAAAAGCCTTTAGTGGATATTTGGGAACAGATCAAAGTAAATGGAAG
GCTTATGATGCTACCCACCTTGTGAAATCCTATCCAGGATCTCAGCTGGACATACTAATT
GATCAAGGGAAAGATGACCAGTTTCTTTTAGATGGACAGTTACTCCCTGATAACTTCATA
GCTGCCTGTACAGAAAAGAAAATCCCCGTTGTTTTTCGATTGCAAGAGGGTTATGATCAT
AGCTACTACTTCATTGCAACCTTTATTACTGACCACATCAGACATCATGCTAAATACCTG
AATGCATGA
|
Protein Properties |
Number of Residues
| 282 |
Molecular Weight
| 31462.545 |
Theoretical pI
| 7.014 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>S-formylglutathione hydrolase
MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQN
FISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRM
YSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVL
CPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFI
AACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P10768 |
UniProtKB/Swiss-Prot Entry Name
| ESTD_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF112219 |
GeneCard ID
| ESD |
GenAtlas ID
| ESD |
HGNC ID
| HGNC:3465 |
References |
General References
| Not Available |