Identification
HMDB Protein ID CDBP00482
Secondary Accession Numbers Not Available
Name S-formylglutathione hydrolase
Description Not Available
Synonyms
  1. Esterase D
  2. FGH
  3. Methylumbelliferyl-acetate deacetylase
Gene Name ESD
Protein Type Enzyme
Biological Properties
General Function Involved in carboxylesterase activity
Specific Function Serine hydrolase involved in the detoxification of formaldehyde.
GO Classification
Biological Process
formaldehyde catabolic process
Cellular Component
Golgi apparatus
nucleus
cytoplasmic membrane-bounded vesicle
Component
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
organelle
vesicle
Function
carboxylesterase activity
thiolester hydrolase activity
s-formylglutathione hydrolase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
Molecular Function
carboxylesterase activity
methylumbelliferyl-acetate deacetylase activity
S-formylglutathione hydrolase activity
Cellular Location
  1. Cytoplasm
  2. Cytoplasmic vesicle
Pathways
Gene Properties
Chromosome Location 13
Locus 13q14.1-q14.2
SNPs ESD
Gene Sequence
>849 bp
ATGGCATTGAAGCAGATTTCCAGCAACAAGTGCTTTGGGGGATTGCAGAAAGTTTTTGAA
CATGACAGTGTTGAACTAAACTGCAAAATGAAATTTGCTGTCTACTTACCACCAAAGGCA
GAAACAGGAAAGTGCCCTGCACTGTATTGGCTCTCAGGTTTAACTTGCACAGAGCAAAAT
TTTATATCAAAATCTGGTTATCATCAGTCTGCTTCAGAACATGGTCTTGTTGTCATTGCT
CCAGATACCAGCCCTCGTGGCTGCAATATTAAAGGTGAAGATGAGAGCTGGGACTTTGGC
ACTGGTGCTGGATTTTATGTTGATGCCACTGAAGATCCTTGGAAAACCAACTACAGAATG
TACTCTTATGTCACAGAGGAGCTTCCCCAACTCATAAATGCCAATTTTCCAGTGGATCCC
CAAAGGATGTCTATTTTTGGCCACTCCATGGGAGGTCATGGAGCTCTGATCTGTGCTTTG
AAAAATCCTGGAAAATACAAATCTGTGTCAGCATTTGCTCCAATTTGCAACCCTGTACTC
TGTCCCTGGGGCAAAAAAGCCTTTAGTGGATATTTGGGAACAGATCAAAGTAAATGGAAG
GCTTATGATGCTACCCACCTTGTGAAATCCTATCCAGGATCTCAGCTGGACATACTAATT
GATCAAGGGAAAGATGACCAGTTTCTTTTAGATGGACAGTTACTCCCTGATAACTTCATA
GCTGCCTGTACAGAAAAGAAAATCCCCGTTGTTTTTCGATTGCAAGAGGGTTATGATCAT
AGCTACTACTTCATTGCAACCTTTATTACTGACCACATCAGACATCATGCTAAATACCTG
AATGCATGA
Protein Properties
Number of Residues 282
Molecular Weight 31462.545
Theoretical pI 7.014
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>S-formylglutathione hydrolase
MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQN
FISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRM
YSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVL
CPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFI
AACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P10768
UniProtKB/Swiss-Prot Entry Name ESTD_HUMAN
PDB IDs
GenBank Gene ID AF112219
GeneCard ID ESD
GenAtlas ID ESD
HGNC ID HGNC:3465
References
General References Not Available