| Identification |
|---|
| HMDB Protein ID
| CDBP00766 |
| Secondary Accession Numbers
| Not Available |
| Name
| Microsomal glutathione S-transferase 2 |
| Description
| Not Available |
| Synonyms
|
- Microsomal GST-2
- Microsomal GST-II
|
| Gene Name
| MGST2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in enzyme activator activity |
| Specific Function
| Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.
|
| GO Classification
|
| Biological Process |
| response to organic nitrogen |
| response to lipopolysaccharide |
| positive regulation of catalytic activity |
| xenobiotic metabolic process |
| glutathione biosynthetic process |
| leukotriene biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| plasma membrane |
| nuclear envelope |
| integral to membrane |
| Component |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| Function |
| enzyme regulator activity |
| enzyme activator activity |
| Molecular Function |
| glutathione peroxidase activity |
| glutathione transferase activity |
| enzyme activator activity |
| leukotriene-C4 synthase activity |
| Process |
| unsaturated fatty acid metabolic process |
| icosanoid metabolic process |
| leukotriene metabolic process |
| metabolic process |
| cellular metabolic process |
| organic acid metabolic process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| monocarboxylic acid metabolic process |
| fatty acid metabolic process |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
- Microsome membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q28.3 |
| SNPs
| MGST2 |
| Gene Sequence
|
>444 bp
ATGGCCGGGAACTCGATCCTGCTGGCTGCTGTCTCTATTCTCTCGGCCTGTCAGCAAAGT
TATTTTGCTTTGCAAGTTGGAAAGGCAAGATTAAAATACAAAGTTACGCCCCCAGCAGTC
ACTGGGTCACCAGAGTTTGAGAGAGTATTTCGGGCACAACAAAACTGTGTGGAGTTTTAT
CCTATATTCATAATTACATTGTGGATGGCTGGGTGGTATTTCAACCAAGTTTTTGCTACT
TGTCTGGGTCTGGTGTACATATATGGCCGTCACCTATACTTCTGGGGATATTCAGAAGCT
GCTAAAAAACGGATCACCGGTTTCCGACTGAGTCTGGGGATTTTGGCCTTGTTGACCCTC
CTAGGTGCCCTGGGAATTGCAAACAGCTTTCTGGATGAATATCTGGACCTCAATATTGCC
AAGAAACTGAGGCGGCAATTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 147 |
| Molecular Weight
| 16620.4 |
| Theoretical pI
| 9.557 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Microsomal glutathione S-transferase 2
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY
PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL
LGALGIANSFLDEYLDLNIAKKLRRQF
|
| External Links |
|---|
| GenBank ID Protein
| 1747521 |
| UniProtKB/Swiss-Prot ID
| Q99735 |
| UniProtKB/Swiss-Prot Entry Name
| MGST2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U77604 |
| GeneCard ID
| MGST2 |
| GenAtlas ID
| MGST2 |
| HGNC ID
| HGNC:7063 |
| References |
|---|
| General References
| Not Available |