Showing Protein Microsomal glutathione S-transferase 2 (CDBP00766)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP00766
Secondary Accession Numbers Not Available
Name Microsomal glutathione S-transferase 2
Description Not Available
Synonyms
  1. Microsomal GST-2
  2. Microsomal GST-II
Gene Name MGST2
Protein Type Enzyme
Biological Properties
General Function Involved in enzyme activator activity
Specific Function Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.
GO Classification
Biological Process
response to organic nitrogen
response to lipopolysaccharide
positive regulation of catalytic activity
xenobiotic metabolic process
glutathione biosynthetic process
leukotriene biosynthetic process
Cellular Component
nuclear envelope
integral to membrane
endoplasmic reticulum membrane
plasma membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
enzyme regulator activity
enzyme activator activity
Molecular Function
glutathione peroxidase activity
glutathione transferase activity
enzyme activator activity
leukotriene-C4 synthase activity
Process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
leukotriene metabolic process
metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
Cellular Location
  1. Multi-pass membrane protein (Potential)
  2. Multi-pass membrane protein (Potential)
  3. Endoplasmic reticulum membrane
  4. Microsome membrane
Pathways
Gene Properties
Chromosome Location 4
Locus 4q28.3
SNPs MGST2
Gene Sequence 
>444 bp
ATGGCCGGGAACTCGATCCTGCTGGCTGCTGTCTCTATTCTCTCGGCCTGTCAGCAAAGT
TATTTTGCTTTGCAAGTTGGAAAGGCAAGATTAAAATACAAAGTTACGCCCCCAGCAGTC
ACTGGGTCACCAGAGTTTGAGAGAGTATTTCGGGCACAACAAAACTGTGTGGAGTTTTAT
CCTATATTCATAATTACATTGTGGATGGCTGGGTGGTATTTCAACCAAGTTTTTGCTACT
TGTCTGGGTCTGGTGTACATATATGGCCGTCACCTATACTTCTGGGGATATTCAGAAGCT
GCTAAAAAACGGATCACCGGTTTCCGACTGAGTCTGGGGATTTTGGCCTTGTTGACCCTC
CTAGGTGCCCTGGGAATTGCAAACAGCTTTCTGGATGAATATCTGGACCTCAATATTGCC
AAGAAACTGAGGCGGCAATTCTAA
Protein Properties
Number of Residues 147
Molecular Weight 16620.4
Theoretical pI 9.557
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Microsomal glutathione S-transferase 2
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY
PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL
LGALGIANSFLDEYLDLNIAKKLRRQF
GenBank ID Protein 1747521
UniProtKB/Swiss-Prot ID Q99735
UniProtKB/Swiss-Prot Entry Name MGST2_HUMAN
PDB IDs Not Available
GenBank Gene ID U77604
GeneCard ID MGST2
GenAtlas ID MGST2
HGNC ID HGNC:7063
References
General References Not Available