| Identification |
|---|
| HMDB Protein ID
| CDBP00763 |
| Secondary Accession Numbers
| Not Available |
| Name
| Microsomal glutathione S-transferase 1 |
| Description
| Not Available |
| Synonyms
|
- Microsomal GST-1
- Microsomal GST-I
|
| Gene Name
| MGST1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
|
| GO Classification
|
| Biological Process |
| Leydig cell differentiation |
| response to lipopolysaccharide |
| response to drug |
| glutathione metabolic process |
| xenobiotic metabolic process |
| cellular response to lipid hydroperoxide |
| protein homotrimerization |
| small molecule metabolic process |
| response to organic nitrogen |
| Cellular Component |
| endoplasmic reticulum membrane |
| apical part of cell |
| mitochondrion |
| nucleus |
| peroxisomal membrane |
| mitochondrial outer membrane |
| integral to membrane |
| mitochondrial inner membrane |
| Molecular Function |
| glutathione binding |
| glutathione transferase activity |
| glutathione peroxidase activity |
|
| Cellular Location
|
- Peripheral membrane protein
- Microsome
- Endoplasmic reticulum
- Mitochondrion outer membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12p12.3-p12.1 |
| SNPs
| MGST1 |
| Gene Sequence
|
>468 bp
ATGGTTGACCTCACCCAGGTAATGGATGATGAAGTATTCATGGCTTTTGCATCCTATGCA
ACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGCAACTGCATTCTATAGATTGACA
AGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAG
AAGTATCTTCGAACAGATGACAGAGTAGAACGTGTACGCAGAGCCCACCTGAATGACCTT
GAAAATATTATTCCATTTCTTGGAATTGGCCTCCTGTATTCCTTGAGTGGTCCCGACCCC
TCTACAGCCATCCTGCACTTCAGACTATTTGTCGGAGCACGGATCTACCACACCATTGCA
TATTTGACACCCCTTCCCCAGCCAAATAGAGCTTTGAGTTTTTTTGTTGGATATGGAGTT
ACTCTTTCCATGGCTTACAGGTTGCTGAAAAGTAAATTGTACCTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 155 |
| Molecular Weight
| 17598.45 |
| Theoretical pI
| 9.386 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Microsomal glutathione S-transferase 1
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAK
KYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIA
YLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P10620 |
| UniProtKB/Swiss-Prot Entry Name
| MGST1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| J03746 |
| GeneCard ID
| MGST1 |
| GenAtlas ID
| MGST1 |
| HGNC ID
| HGNC:7061 |
| References |
|---|
| General References
| Not Available |