| Identification |
|---|
| HMDB Protein ID
| CDBP00779 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutathione S-transferase P |
| Description
| Not Available |
| Synonyms
|
- GST class-pi
- GSTP1-1
|
| Gene Name
| GSTP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
|
| GO Classification
|
| Biological Process |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor-mediated signaling pathway |
| nitric oxide storage |
| positive regulation of superoxide anion generation |
| response to reactive oxygen species |
| glutathione metabolic process |
| negative regulation of apoptotic process |
| cellular response to lipopolysaccharide |
| negative regulation of fibroblast proliferation |
| xenobiotic metabolic process |
| common myeloid progenitor cell proliferation |
| negative regulation of acute inflammatory response |
| negative regulation of JUN kinase activity |
| negative regulation of I-kappaB kinase/NF-kappaB cascade |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of interleukin-1 beta production |
| central nervous system development |
| negative regulation of leukocyte proliferation |
| negative regulation of monocyte chemotactic protein-1 production |
| negative regulation of necrotic cell death |
| negative regulation of nitric-oxide synthase biosynthetic process |
| negative regulation of stress-activated MAPK cascade |
| Cellular Component |
| cytosol |
| mitochondrion |
| nucleus |
| TRAF2-GSTP1 complex |
| Function |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| glutathione transferase activity |
| catalytic activity |
| Molecular Function |
| glutathione transferase activity |
| dinitrosyl-iron complex binding |
| JUN kinase binding |
| kinase regulator activity |
| nitric oxide binding |
| S-nitrosoglutathione binding |
| Process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  | | Prostate cancer | Not Available |  | | Acetaminophen Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13 |
| SNPs
| GSTP1 |
| Gene Sequence
|
>632 bp
TGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATGC
TGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAGG
AGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACC
TCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTATG
GGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCC
GCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTGA
AGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGCA
AGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGC
TGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATATG
TGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTGA
ACCTCCCCATCAATGGCAACGGGAAACAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 210 |
| Molecular Weight
| 23355.625 |
| Theoretical pI
| 5.64 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione S-transferase P
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
|
| External Links |
|---|
| GenBank ID Protein
| 32187525 |
| UniProtKB/Swiss-Prot ID
| P09211 |
| UniProtKB/Swiss-Prot Entry Name
| GSTP1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AY324387 |
| GeneCard ID
| GSTP1 |
| GenAtlas ID
| GSTP1 |
| HGNC ID
| HGNC:4638 |
| References |
|---|
| General References
| Not Available |