| Identification |
|---|
| HMDB Protein ID
| CDBP02596 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gamma-glutamyltransferase 6 |
| Description
| Not Available |
| Synonyms
|
- GGT 6
- Gamma-glutamyltransferase 6 heavy chain
- Gamma-glutamyltransferase 6 light chain
- Gamma-glutamyltranspeptidase 6
- Glutathione hydrolase 6
|
| Gene Name
| GGT6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in gamma-glutamyltransferase activity |
| Specific Function
| Cleaves glutathione conjugates (By similarity).
|
| GO Classification
|
| Biological Process |
| glutathione metabolic process |
| glutathione biosynthetic process |
| leukotriene biosynthetic process |
| Cellular Component |
| anchored to external side of plasma membrane |
| integral to membrane |
| Function |
| transferase activity, transferring amino-acyl groups |
| gamma-glutamyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| Molecular Function |
| gamma-glutamyltransferase activity |
| hydrolase activity |
|
| Cellular Location
|
- Membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Cyanoamino acid metabolism | Not Available |  | | Taurine and Hypotaurine Metabolism |    |  | | Glutathione Metabolism |    |  | | Glutathione Synthetase Deficiency |    | Not Available | | 5-Oxoprolinuria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p13.2 |
| SNPs
| GGT6 |
| Gene Sequence
|
>1482 bp
ATGGAGCGGGCAGAAGAGCCCGTGGTCTATCAGAAGCTGCTGCCCTGGGAGCCAAGCTTG
GAGTCGGAGGAGGAAGTGGAGGAGGAGGAGACATCAGAGGCGCTGGTTCTAAACCCCCGG
AGGCACCAGGACTCTTCCAGGAACAAGGCTGGCGGGCTGCCCGGAACCTGGGCCCGTGTA
GTGGCAGCCCTGCTGCTGCTGGCTGTTGGCTGCTCCCTGGCTGTGAGGCAGCTCCAGAAT
CAGGGCAGGTCGACAGGAAGCTTGGGCTCTGTGGCCCCTCCACCCGGCGGACACTCCCAC
GGCCCTGGCGTATACCACCACGGTGCCATCATCAGCCCTGCAGGCCGAGAGCTGCTTGTT
GCCGGGGGCAACGTCGTGGATGCTGGAGTTGGAGCTGCATTGTGCCTGGCAGTGGTGCAT
CCTCATGCCACGGGGCTAGGTGCCATGTTTTGGGGCCTCTTCCACGATAGCTCCTCAGGC
AATTCCACGGCCCTGACATCAGGCCCAGCACAGACCCTGGCCCCCGGCCTGGGGCTGCCC
GCGGCTCTGCCCACCCTGCACCTGCTGCATGCACGCTTCGGCCGCCTGCCCTGGCCACGC
CTGCTAGTGGGCCCCACCACGCTGGCTCAGGAGGGCTTCCTGGTGGACACACCCCTGGCA
AGGGCTCTGGTGGCTCGGGGCACAGAAGGCCTCTGTCCACTACTTTGCCATGCTGATGGG
ACACCCCTGGGCGCTGGGGCCCGAGCCACCAACCCACAACTGGCAGCTGTGCTTCGCAGC
GCAGCCCTCGCTCCCACCTCAGACCTTGCTGGGGATGCTCTACTGAGTCTACTGGCGGGA
GACCTGGGGGTGGAGGTGCCCTCGGCTGTGCCCAGGCCCACTTTGGAACCAGCAGAGCAG
CTACCTGTGCCCCAGGGCATCCTGTTCACCACCCCCAGTCCCTCAGCTGGCCCAGAACTG
CTGGCACTGTTGGAGGCAGCCCTGCGCTCCGGGGCGCCCATCCCTGACCCCTGCCCACCG
TTCCTGCAGACTGCTGTGAGCCCCGAGAGCAGTGCCCTGGCCGCCGTGGACAGCAGCGGC
TCTGTGCTCCTTCTCACCTCCTCGCTCAACTGCTCCTTTGGCTCTGCACACCTGTCCCCA
AGCACTGGGGTTCTGCTCAGCAACCTGGTGGCCAAGTCTACCACTAGTGCCTGGGCCTGC
CCCCTCATCCTCCGTGGCAGCCTGGATGACACAGAGGCTGATGTGTTGGGGCTTGTGGCT
TCAGGGACCCCTGATGTGGCCAGGGCCATGACTCACACCCTACTCAGGCATCTGGCAGCA
AGGCCCCCTACCCAGGCCCAGCACCAGCATCAGGGTCAGCAAGAACCAACAGAGCATCCC
AGCACTTGTGGCCAAGGGACCCTGCTCCAGGTGGCAGCCCACACAGAGCACGCCCATGTC
TCCAGTGTCCCCCATGCCTGCTGCCCCTTCCAGGGGTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 493 |
| Molecular Weight
| 50508.83 |
| Theoretical pI
| 6.079 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Gamma-glutamyltransferase 6
MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPRRHQDSSRNKAGGLPGTWARV
VAALLLLAVGCSLAVRQLQNQGRSTGSLGSVAPPPGGHSHGPGVYHHGAIISPAGRELLV
AGGNVVDAGVGAALCLAVVHPHATGLGAMFWGLFHDSSSGNSTALTSGPAQTLAPGLGLP
AALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARALVARGTEGLCPLLCHADG
TPLGAGARATNPQLAAVLRSAALAPTSDLAGDALLSLLAGDLGVEVPSAVPRPTLEPAEQ
LPVPQGILFTTPSPSAGPELLALLEAALRSGAPIPDPCPPFLQTAVSPESSALAAVDSSG
SVLLLTSSLNCSFGSAHLSPSTGVLLSNLVAKSTTSAWACPLILRGSLDDTEADVLGLVA
SGTPDVARAMTHTLLRHLAARPPTQAQHQHQGQQEPTEHPSTCGQGTLLQVAAHTEHAHV
SSVPHACCPFQGF
|
| External Links |
|---|
| GenBank ID Protein
| 171543825 |
| UniProtKB/Swiss-Prot ID
| Q6P531 |
| UniProtKB/Swiss-Prot Entry Name
| GGT6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001122890.1 |
| GeneCard ID
| GGT6 |
| GenAtlas ID
| GGT6 |
| HGNC ID
| HGNC:26891 |
| References |
|---|
| General References
| Not Available |