| Identification |
|---|
| HMDB Protein ID
| CDBP00762 |
| Secondary Accession Numbers
| Not Available |
| Name
| Maleylacetoacetate isomerase |
| Description
| Not Available |
| Synonyms
|
- GSTZ1-1
- Glutathione S-transferase zeta 1
- MAAI
|
| Gene Name
| GSTZ1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
|
| GO Classification
|
| Biological Process |
| glutathione metabolic process |
| L-phenylalanine catabolic process |
| tyrosine catabolic process |
| Cellular Component |
| cytosol |
| mitochondrion |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| Molecular Function |
| glutathione peroxidase activity |
| glutathione transferase activity |
| maleylacetoacetate isomerase activity |
| Process |
| cellular metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| aromatic amino acid family metabolic process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-phenylalanine degradation | Not Available | Not Available | | Phenylalanine and Tyrosine Metabolism |    |  | | Phenylketonuria |    | Not Available | | Tyrosinemia Type 2 (or Richner-Hanhart syndrome) |    | Not Available | | Tyrosinemia Type 3 (TYRO3) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q24.3 |
| SNPs
| GSTZ1 |
| Gene Sequence
|
>651 bp
ATGCAGGCGGGGAAGCCCATCCTCTATTCCTATTTCCGAAGCTCCTGCTCATGGAGAGTT
CGAATTGCTCTGGCCTTGAAAGGCATCGACTACGAGACGGTGCCCATCAATCTCATAAAG
GATGGGGGCCAACAGTTTTCTAAGGACTTCCAGGCACTGAATCCTATGAAGCAGGTGCCA
ACCCTGAAGATTGATGGAATCACCATTCACCAGTCACTGGCCATCATTGAGTATCTAGAG
GAGATGCGTCCCACTCCGCGACTTCTGCCTCAGGACCCAAAGAAGAGGGCCAGCGTGCGT
ATGATTTCTGACCTCATCGCTGGTGGCATCCAGCCCCTGCAGAACCTGTCTGTCCTGAAG
CAAGTGGGAGAGGAGATGCAGCTGACCTGGGCCCAGAACGCCATCACTTGTGGCTTTAAC
GCCCTGGAGCAGATCCTACAGAGCACAGCGGGCATATACTGTGTAGGAGACGAGGTGACC
ATGGCTGATCTGTGCTTGGTGCCTCAGGTGGCAAATGCTGAAAGATTCAAGGTGGATCTC
ACCCCCTACCCTACCATCAGCTCCATCAACAAGAGGCTGCTGGTCTTGGAGGCCTTCCAG
GTGTCTCACCCCTGCCGGCAGCCAGATACACCCACTGAGCTGAGGGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 216 |
| Molecular Weight
| 17895.68 |
| Theoretical pI
| 5.954 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Maleylacetoacetate isomerase
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVP
TLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
|
| External Links |
|---|
| GenBank ID Protein
| 7417477 |
| UniProtKB/Swiss-Prot ID
| O43708 |
| UniProtKB/Swiss-Prot Entry Name
| MAAI_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AC007954 |
| GeneCard ID
| GSTZ1 |
| GenAtlas ID
| GSTZ1 |
| HGNC ID
| HGNC:4643 |
| References |
|---|
| General References
| Not Available |