| Identification |
|---|
| HMDB Protein ID
| CDBP00772 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutathione S-transferase A4 |
| Description
| Not Available |
| Synonyms
|
- GST class-alpha member 4
- Glutathione S-transferase A4-4
|
| Gene Name
| GSTA4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione transferase activity |
| Specific Function
| Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
|
| GO Classification
|
| Biological Process |
| xenobiotic metabolic process |
| glutathione metabolic process |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| glutathione transferase activity |
| Molecular Function |
| glutathione transferase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p12.1 |
| SNPs
| GSTA4 |
| Gene Sequence
|
>669 bp
ATGGCAGCAAGGCCCAAGCTCCACTATCCCAACGGAAGAGGCCGGATGGAGTCCGTGAGA
TGGGTTTTAGCTGCCGCCGGAGTCGAGTTTGATGAAGAATTTCTGGAAACAAAAGAACAG
TTGTACAAGTTGCAGGATGGTAACCACCTGCTGTTCCAACAAGTGCCCATGGTTGAAATT
GACGGGATGAAGTTGGTACAGACCCGAAGCATTCTCCACTACATAGCAGACAAGCACAAT
CTCTTTGGCAAGAACCTCAAGGAGAGAACCCTGATTGACATGTACGTGGAGGGGACACTG
GATCTGCTGGAACTGCTTATCATGCATCCTTTCTTAAAACCAGATGATCAGCAAAAGGAA
GTGGTTAACATGGCCCAGAAGGCTATAATTAGATACTTTCCTGTGTTTGAAAAGATTTTA
AGGGGTCACGGACAAAGCTTTCTTGTTGGTAATCAGCTGAGCCTTGCAGATGTGATTTTA
CTCCAAACCATTTTAGCTCTAGAAGAGAAAATTCCTAATATCCTGTCTGCATTTCCTTTC
CTCCAGGAATACACAGTGAAACTAAGTAATATCCCTACAATTAAGAGATTCCTTGAACCT
GGCAGCAAGAAGAAGCCTCCCCCTGATGAAATTTATGTGAGAACCGTCTACAACATCTTT
AGGCCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 222 |
| Molecular Weight
| 25703.905 |
| Theoretical pI
| 8.267 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione S-transferase A4
MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEI
DGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKE
VVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPF
LQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP
|
| External Links |
|---|
| GenBank ID Protein
| 2597924 |
| UniProtKB/Swiss-Prot ID
| O15217 |
| UniProtKB/Swiss-Prot Entry Name
| GSTA4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Y13047 |
| GeneCard ID
| GSTA4 |
| GenAtlas ID
| GSTA4 |
| HGNC ID
| HGNC:4629 |
| References |
|---|
| General References
| Not Available |