Cannabis Compound Database: Showing Compound Card for Pyruvic acid (CDB004829)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (50)transporters (8) Show 86 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:41:03 UTC

Updated at

2022-12-13 23:36:29 UTC

CannabisDB ID

CDB004829

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Pyruvic acid

Description

Pyruvic acid, also known as pyroracemic acid or 2-oxopropanoate, belongs to the class of organic compounds known as alpha-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon. Pyruvic acid is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. Pyruvic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Pyruvic acid exists in all living species, ranging from bacteria to humans. Outside of the human body, Pyruvic acid has been detected, but not quantified in, several different foods, such as ohelo berries, cottonseeds, chinese cinnamons, common sages, and vanilla. This could make pyruvic acid a potential biomarker for the consumption of these foods. A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. Pyruvic acid is a potentially toxic compound. Pyruvic acid is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Ketopropionic acid	ChEBI
2-Oxopropanoic acid	ChEBI
2-Oxopropansaeure	ChEBI
2-Oxopropionsaeure	ChEBI
Acetylformic acid	ChEBI
Acide pyruvique	ChEBI
alpha-Ketopropionic acid	ChEBI
alpha-Oxopropionsaeure	ChEBI
Brenztraubensaeure	ChEBI
BTS	ChEBI
CH3COCOOH	ChEBI
Pyroracemic acid	ChEBI
2-Oxopropanoate	Kegg
2-Ketopropionate	Generator
Acetylformate	Generator
a-Ketopropionate	Generator
a-Ketopropionic acid	Generator
alpha-Ketopropionate	Generator
Α-ketopropionate	Generator
Α-ketopropionic acid	Generator
a-Oxopropionsaeure	Generator
Α-oxopropionsaeure	Generator
Pyroracemate	Generator
Pyruvate	Generator
2-Oxopropionate	HMDB
2-Oxopropionic acid	HMDB
Acid, pyruvic	MeSH, HMDB
Pyruvic acid	HMDB
alpha-Ketopropanoic acid	HMDB
α-Ketopropanoic acid	HMDB

Chemical Formula

C₃H₄O₃

Average Molecular Weight

88.06

Monoisotopic Molecular Weight

88.016

IUPAC Name

2-oxopropanoic acid

Traditional Name

pyruvic acid

CAS Registry Number

127-17-3

SMILES

CC(=O)C(O)=O

InChI Identifier

InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)

InChI Key

LCTONWCANYUPML-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Keto acids and derivatives

Sub Class

Alpha-keto acids and derivatives

Direct Parent

Alpha-keto acids and derivatives

Alternative Parents

Substituents

Alpha-keto acid
Alpha-hydroxy ketone
Ketone
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

2-oxo monocarboxylic acid (CHEBI:32816 )
Oxo fatty acids (LMFA01060077 )

Ontology

Physiological effect

Health effect:

Health condition:

Metabolism and nutrition disorders:

3-methylglutaconic aciduria type ii, x-linked

Infections and infestations:

Meningitis

Corynebacterium glutamicum

Escherichia:

Escherichia coli

Plant:

Biological location:

Role

Industrial application:

Food and nutrition

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Liquid

Experimental Properties

Property	Value	Reference
Melting Point	13.8 °C	Not Available
Boiling Point	165 °C	Wikipedia
Water Solubility	1000 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.38	ALOGPS
logP	0.066	ChemAxon
logS	0.18	ALOGPS
pKa (Strongest Acidic)	2.93	ChemAxon
pKa (Strongest Basic)	-9.6	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	54.37 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	17.99 m³·mol⁻¹	ChemAxon
Polarizability	7.31 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-0006-9000000000-f315d0752893e7d0c657	2014-09-20	View Spectrum
GC-MS	Pyruvic acid, non-derivatized, GC-MS Spectrum	splash10-00dr-4900000000-f26ef76666e40ab9fe61	Spectrum
GC-MS	Pyruvic acid, 1 MEOX; 1 TMS, GC-MS Spectrum	splash10-00di-5900000000-b8e81f82572d4796e944	Spectrum
GC-MS	Pyruvic acid, 2 TMS, GC-MS Spectrum	splash10-014i-5970000000-154bf9ad168a12593fcc	Spectrum
GC-MS	Pyruvic acid, non-derivatized, GC-MS Spectrum	splash10-0006-9000000000-a2cf85a5e1d2379d26df	Spectrum
GC-MS	Pyruvic acid, non-derivatized, GC-MS Spectrum	splash10-00dr-4900000000-f26ef76666e40ab9fe61	Spectrum
GC-MS	Pyruvic acid, non-derivatized, GC-MS Spectrum	splash10-00di-5900000000-b8e81f82572d4796e944	Spectrum
GC-MS	Pyruvic acid, non-derivatized, GC-MS Spectrum	splash10-014i-5970000000-154bf9ad168a12593fcc	Spectrum
GC-MS	Pyruvic acid, non-derivatized, GC-MS Spectrum	splash10-00dr-5900000000-5b1f470d4ff91420618c	Spectrum
Predicted GC-MS	Pyruvic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0006-9000000000-5417b44aa241a7ba27e8	Spectrum
Predicted GC-MS	Pyruvic acid, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dm-9400000000-6db65a709bdc47e3adf7	Spectrum
Predicted GC-MS	Pyruvic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Pyruvic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Pyruvic acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Pyruvic acid, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Pyruvic acid, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI M-80B) , Positive	splash10-0006-9000000000-a2cf85a5e1d2379d26df	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-000i-9000000000-dd49835da8355fb6e625	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-000i-9000000000-f09d8e3d7a774b255d89	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0006-9000000000-7d91f6f626cab1a366fd	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9000000000-8ae98cdb3e142034e52a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-e04e6c68013983e1b6dc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-000i-9000000000-dd49835da8355fb6e625	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-000i-9000000000-f09d8e3d7a774b255d89	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-7d91f6f626cab1a366fd	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-8ae98cdb3e142034e52a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-e04e6c68013983e1b6dc	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-000f-9000000000-f24c93ecfd3928827154	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0udj-9000000000-fc3b9ad0c57f44261fba	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-014i-9000000000-f3444f8b94ee5a0a9f74	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 33V, Negative	splash10-0avr-9000000000-dc40a6a1b9b166d6e68a	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 33V, Negative	splash10-016r-9000000000-efac7b176bb77118ecb8	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-9000000000-d0defa72b09503c6d6d1	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000f-9000000000-c25fa150e9c490319a2a	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0006-9000000000-ccb42b4c05ddd001990f	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-000i-9000000000-faf36ff70d6205370270	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-000i-9000000000-60c1a02aabf80f51050f	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-000f-9000000000-ca5f4a2f06787d8b62a0	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0006-9000000000-0eb1fb2cdd24bdc78601	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0006-9000000000-87bbaed151efac084591	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0006-9000000000-87bbaed151efac084591	2021-09-22	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, CDCl₃, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 25.16 MHz, CDCl₃, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Urea Cycle
Glucose-Alanine Cycle		Not Available
Glycine and Serine Metabolism
Pyruvate Metabolism
Alanine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	3p21.1-p14.2	P11177	details
Pyruvate carboxylase, mitochondrial	PC	11q13.4-q13.5	P11498	details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	PDHA1	Xp22.1	P08559	details
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	PDHA2	4q22-q23	P29803	details
Dihydrolipoyl dehydrogenase, mitochondrial	DLD	7q31-q32	P09622	details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	11q23.1	P10515	details
D-amino-acid oxidase	DAO	12q24	P14920	details
4-aminobutyrate aminotransferase, mitochondrial	ABAT	16p13.2	P80404	details
Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	5p13	Q9BYV1	details
S-adenosylmethionine decarboxylase proenzyme	AMD1	6q21	P17707	details
Kynurenine--oxoglutarate transaminase 1	CCBL1	9q34.11	Q16773	details
Cystathionine gamma-lyase	CTH	1p31.1	P32929	details
L-serine dehydratase/L-threonine deaminase	SDS	12q24.13	P20132	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
3-mercaptopyruvate sulfurtransferase	MPST	22q13.1	P25325	details
Serine--pyruvate aminotransferase	AGXT	2q37.3	P21549	details
Alanine aminotransferase 1	GPT	8q24.3	P24298	details
Histidine decarboxylase	HDC	15q21-q22	P19113	details
L-lactate dehydrogenase A-like 6A	LDHAL6A	11p15.1	Q6ZMR3	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Thiosulfate sulfurtransferase	TST	22q13.1	Q16762	details
Monocarboxylate transporter 3	SLC16A8	22q12.3-q13.2	O95907	details
Monocarboxylate transporter 7	SLC16A6	17q24.2	O15403	details
Monocarboxylate transporter 6	SLC16A5	17q25.1	O15375	details
Monocarboxylate transporter 5	SLC16A4	1p13.3	O15374	details
Phosphatidylserine decarboxylase proenzyme	PISD	22q12.2	Q9UG56	details
L-lactate dehydrogenase B chain	LDHB	12p12.2-p12.1	P07195	details
L-lactate dehydrogenase C chain	LDHC	11p15.1	P07864	details
L-lactate dehydrogenase A chain	LDHA	11p15.4	P00338	details
L-lactate dehydrogenase A-like 6B	LDHAL6B	15q22.2	Q9BYZ2	details
Probable D-lactate dehydrogenase, mitochondrial	LDHD	16q23.1	Q86WU2	details
Alanine aminotransferase 2	GPT2	16q12.1	Q8TD30	details
Selenocysteine lyase	SCLY	2q37.3	Q96I15	details
N-acetylneuraminate lyase	NPL	1q25	Q9BXD5	details
Acetolactate synthase-like protein	ILVBL	19p13.1	A1L0T0	details
Malic enzyme	ME3	11cen-q22.3	Q8TBJ0	details
Acylpyruvase FAHD1, mitochondrial	FAHD1	16p13.3	Q6P587	details
Kynurenine--oxoglutarate transaminase 3	CCBL2	1p22.2	Q6YP21	details
Serine dehydratase-like	SDSL	12q24.13	Q96GA7	details
Serine racemase	SRR	17p13	Q9GZT4	details
Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial	HOGA1	10q24.2	Q86XE5	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 3	SLC16A8	22q12.3-q13.2	O95907	details
Monocarboxylate transporter 4	SLC16A3	17q25	O15427	details
Monocarboxylate transporter 1	SLC16A1	1p12	P53985	details
Monocarboxylate transporter 8	SLC16A2		P36021	details
Monocarboxylate transporter 6	SLC16A5	17q25.1	O15375	details
Monocarboxylate transporter 2	SLC16A7	12q13	O60669	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details
Solute carrier organic anion transporter family member 2A1	SLCO2A1	3q21	Q92959	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Pyruvate carboxylase, mitochondrial	PC	11q13.4-q13.5	P11498	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
NADP-dependent malic enzyme	ME1	6q12	P48163	details
NADP-dependent malic enzyme, mitochondrial	ME3	11cen-q22.3	Q16798	details
NAD-dependent malic enzyme, mitochondrial	ME2	18q21	P23368	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Acetolactate synthase-like protein	ILVBL	19p13.1	A1L0T0	details
Malic enzyme	ME3	11cen-q22.3	Q8TBJ0	details
Acylpyruvase FAHD1, mitochondrial	FAHD1	16p13.3	Q6P587	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Cystathionine gamma-lyase	CTH	1p31.1	P32929	details

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.00178 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.00245 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.00260 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.00238 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.00340 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.00271 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000243

DrugBank ID

DB00119

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB031141

KNApSAcK ID

C00001200

Chemspider ID

Not Available

KEGG Compound ID

C00022

BioCyc ID

PYRUVATE

BiGG ID

Not Available

Wikipedia Link

Pyruvic_acid

METLIN ID

Not Available

PubChem Compound

1060

PDB ID

Not Available

ChEBI ID

32816

References

General References

Not Available

Only showing the first 10 proteins. There are 86 proteins in total.

Show All

Enzymes

Enzyme Details

1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

General function:: Involved in catalytic activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHB
Uniprot ID:: P11177
Molecular weight:: 39233.1

Enzyme Details

2. Pyruvate carboxylase, mitochondrial

General function:: Involved in catalytic activity
Specific function:: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:: PC
Uniprot ID:: P11498
Molecular weight:: 129632.565

Enzyme Details

3. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA1
Uniprot ID:: P08559
Molecular weight:: 43295.255

Enzyme Details

4. Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA2
Uniprot ID:: P29803
Molecular weight:: 42932.855

Enzyme Details

5. Dihydrolipoyl dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Gene Name:: DLD
Uniprot ID:: P09622
Molecular weight:: 54176.91

Enzyme Details

6. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

General function:: Involved in acyltransferase activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: DLAT
Uniprot ID:: P10515
Molecular weight:: 68996.03

Enzyme Details

7. D-amino-acid oxidase

General function:: Involved in D-amino-acid oxidase activity
Specific function:: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Gene Name:: DAO
Uniprot ID:: P14920
Molecular weight:: 39473.75

Enzyme Details

8. 4-aminobutyrate aminotransferase, mitochondrial

General function:: Involved in 4-aminobutyrate transaminase activity
Specific function:: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:: ABAT
Uniprot ID:: P80404
Molecular weight:: 56438.405

Enzyme Details

9. Alanine--glyoxylate aminotransferase 2, mitochondrial

General function:: Involved in transaminase activity
Specific function:: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Gene Name:: AGXT2
Uniprot ID:: Q9BYV1
Molecular weight:: 57155.905

Enzyme Details

10. S-adenosylmethionine decarboxylase proenzyme

General function:: Involved in adenosylmethionine decarboxylase activity
Specific function:: Not Available
Gene Name:: AMD1
Uniprot ID:: P17707
Molecular weight:: 21301.015

Transporters

Enzyme Details

1. Monocarboxylate transporter 3

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A8
Uniprot ID:: O95907
Molecular weight:: 52318.2

Enzyme Details

2. Monocarboxylate transporter 4

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A3
Uniprot ID:: O15427
Molecular weight:: 49468.9

Enzyme Details

3. Monocarboxylate transporter 1

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A1
Uniprot ID:: P53985
Molecular weight:: 53957.7

Enzyme Details

4. Monocarboxylate transporter 8

General function:: Involved in transmembrane transport
Specific function:: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr
Gene Name:: SLC16A2
Uniprot ID:: P36021
Molecular weight:: 59510.9

Enzyme Details

5. Monocarboxylate transporter 6

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A5
Uniprot ID:: O15375
Molecular weight:: 54993.0

Enzyme Details

6. Monocarboxylate transporter 2

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter
Gene Name:: SLC16A7
Uniprot ID:: O60669
Molecular weight:: 52185.7

Enzyme Details

7. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Enzyme Details

8. Solute carrier organic anion transporter family member 2A1

General function:: Not Available
Specific function:: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A
Gene Name:: SLCO2A1
Uniprot ID:: Q92959
Molecular weight:: 70117.0

Only showing the first 10 proteins. There are 86 proteins in total.

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Showing Compound Card for Pyruvic acid (CDB004829)

Structure for CDB004829 (Pyruvic acid)

Enzymes

Transporters