| Identification |
|---|
| HMDB Protein ID
| CDBP02595 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-acetylneuraminate lyase |
| Description
| Not Available |
| Synonyms
|
- N-acetylneuraminate pyruvate-lyase
- N-acetylneuraminic acid aldolase
- NALase
- Sialate lyase
- Sialate-pyruvate lyase
- Sialic acid aldolase
- Sialic acid lyase
|
| Gene Name
| NPL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).
|
| GO Classification
|
| Biological Process |
| N-acetylneuraminate catabolic process |
| carbohydrate metabolic process |
| Cellular Component |
| cytoplasm |
| Function |
| catalytic activity |
| lyase activity |
| Molecular Function |
| N-acetylneuraminate lyase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amino Sugar Metabolism |    |  | | N-acetylneuraminate degradation | Not Available | Not Available | | Amino sugar and nucleotide sugar metabolism | Not Available | | | Sialuria or French Type Sialuria |    | Not Available | | Salla Disease/Infantile Sialic Acid Storage Disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q25 |
| SNPs
| NPL |
| Gene Sequence
|
>963 bp
ATGGCCTTCCCAAAGAAGAAACTTCAGGGTCTTGTGGCTGCAACCATCACGCCAATGACT
GAGAATGGAGAAATCAACTTTTCAGTAATTGGTCAGTATGTGGATTATCTTGTGAAAGAA
CAGGGAGTGAAGAACATTTTTGTGAATGGCACAACAGGAGAAGGCCTGTCCCTGAGCGTC
TCAGAGCGTCGCCAGGTTGCAGAGGAGTGGGTGACAAAAGGGAAGGACAAGCTGGATCAG
GTGATAATTCACGTAGGAGCACTGAGCTTGAAGGAGTCACAGGAACTGGCCCAACATGCA
GCAGAAATAGGAGCTGATGGCATCGCTGTCATTGCACCGTTCTTCCTCAAGCCATGGACC
AAAGATATCCTGATTAATTTCCTAAAGGAAGTGGCTGCTGCCGCCCCTGCCCTGCCATTT
TATTACTATCACATTCCTGCCTTGACAGGGGTAAAGATTCGTGCTGAGGAGTTGTTGGAT
GGGATTCTGGATAAGATCCCCACCTTCCAAGGGCTGAAATTCAGTGATACAGATCTCTTA
GACTTCGGGCAATGTGTTGATCAGAATCGCCAGCAACAGTTTGCTTTCCTTTTTGGGGTG
GATGAGCAACTGTTGAGTGCTCTGGTGATGGGAGCAACTGGAGCAGTGGGCAGTACCTAT
AACTACCTGGGAAAAAAGACAAACCAGATGTTGGAGGCTTTTGAACAAAAGGACTTCTCT
TTAGCCCTGAACTATCAGTTTTGTATCCAGAGATTTATCAACTTTGTTGTCAAACTAGGT
TTTGGAGTGTCACAGACCAAAGCCATCATGACTCTGGTCTCTGGGATTCCAATGGGCCCA
CCCCGGCTTCCACTGCAGAAAGCCTCCAGGGAGTTTACTGATAGTGCTGAAGCTAAACTG
AAGAGCCTGGATTTCCTTTCTTTCACTGATTTAAAGGATGGAAACTTGGAAGCTGGTAGC
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 320 |
| Molecular Weight
| 33116.95 |
| Theoretical pI
| 7.413 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N-acetylneuraminate lyase
MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSV
SERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHAAEIGADGIAVIAPFFLKPWT
KDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLL
DFGQCVDQNRQQQFAFLFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDFS
LALNYQFCIQRFINFVVKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKASREFTDSAEAKL
KSLDFLSFTDLKDGNLEAGS
|
| External Links |
|---|
| GenBank ID Protein
| 13430285 |
| UniProtKB/Swiss-Prot ID
| Q9BXD5 |
| UniProtKB/Swiss-Prot Entry Name
| NPL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF338436 |
| GeneCard ID
| NPL |
| GenAtlas ID
| NPL |
| HGNC ID
| HGNC:16781 |
| References |
|---|
| General References
| Not Available |