Identification |
HMDB Protein ID
| CDBP01042 |
Secondary Accession Numbers
| Not Available |
Name
| Monocarboxylate transporter 3 |
Description
| Not Available |
Synonyms
|
- MCT 3
- Solute carrier family 16 member 8
|
Gene Name
| SLC16A8 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in transmembrane transport |
Specific Function
| Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate |
GO Classification
|
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
substrate-specific transmembrane transporter activity |
transporter activity |
organic acid transmembrane transporter activity |
carboxylic acid transmembrane transporter activity |
monocarboxylic acid transmembrane transporter activity |
secondary active monocarboxylate transmembrane transporter activity |
transmembrane transporter activity |
Process |
establishment of localization |
transport |
organic anion transport |
transmembrane transport |
anion transport |
ion transport |
|
Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:2 |
Locus
| 22q12.3-q13.2 |
SNPs
| SLC16A8 |
Gene Sequence
|
>1515 bp
ATGGGCGCTGGCGGCCCCCGGCGGGGCGAGGGCCCCCCAGACGGCGGCTGGGGCTGGGTG
GTGCTGGGCGCCTGCTTTGTGGTCACCGGCTTCGCCTACGGCTTCCCCAAAGCCGTGAGC
GTCTTCTTCCGCGCGCTCATGCGCGACTTCGACGCCGGCTACAGCGACACGGCCTGGGTG
TCCTCCATCATGCTAGCCATGCTCTACGGCACGGGCCCCGTGTCCAGCATCCTCGTGACC
CGCTTTGGCTGTCGCCCGGTGATGCTGGCGGGTGGGCTGCTGGCTTCCGCGGGCATGATC
CTAGCTTCCTTTGCCACGCGCCTTCTGGAGCTCTACCTGACCGCTGGGGTGCTCACAGGC
CTGGGCCTGGCCCTCAACTTCCAGCCGTCGCTCATCATGCTGGGGCTGTACTTCGAGCGG
CGGCGGCCTCTGGCCAACGGGCTGGCGGCGGCGGGCAGCCCCGTGTTCCTGTCCGCGCTG
TCGCCGCTCGGCCAGCAGCTGCTGGAGCGCTTCGGCTGGCGCGGCGGCTTCCTGCTGCTC
GGCGGGCTCCTGCTGCACTGCTGCGCCTGCGGGGCTGTCATGAGGCCGCCGCCCGGGCCG
GGCCCGCGACCGCGCAGGGACAGCGCCGGCGACCGCGCCGGGGACGCTCCGGGCGAGGCG
GAGGCTGACGGTGCGGGGCTGCAGCTGCGCGAGGCATCCCCCTGGGTCCGGCCCCGCCGG
CGCCTGCTGGACTTGGCAGTGTGCACCGACCGCGCCTTCGCCGTGTACGCCGTCACCAAG
TTCCTGATGGCGCTCGGGCTCTTCGTCCCCGCCATCCTGCTGGTGAACTACGCCAAGGAC
GCGGGCGTGCCCGACACCGACGCCGCCTTCCTGCTGTCCATCGTGGGCTTCGTGGACATC
GTGGCGCGCCCGGCGTGCGGCGCCCTGGCGGGCCTGGCGCGTCTGCGGCCGCACGTCCCG
TATCTGTTCAGCCTGGCCCTGCTGGCCAATGGGCTCACAGACCTGAGCAGCGCACGCGCG
CGCTCCTACGGCGCCCTCGTCGCCTTCTGCGTCGCCTTCGGCCTCTCCTACGGCATGGTG
GGCGCGCTGCAGTTCGAGGTGCTCATGGCGGCTGTGGGCGCGCCCCGCTTCCCCAGTGCG
CTGGGCCTGGTGTTGCTCGTGGAGGCCGCGGCTGTGCTCATCGGACCGCCCTCTGCCGGC
CGCCTGGTGGATGCGTTGAAGAACTATGAGATCATCTTCTACCTGGCCGGCTCTGAGGTG
GCCCTGGCTGGGGTCTTCATGGCTGTCGCCACCAACTGCTGCCTGCGTTGTGCTAAAGCT
GCCCCGTCAGGCCCAGGCACTGAGGGCGGAGCCAGTGACACTGAGGACGCTGAGGCTGAA
GGGGACTCTGAGCCCCTGCCTGTTGTTGCAGAGGAACCCGGCAACCTGGAGGCCCTGGAG
GTGCTCAGCGCCCGGGGCGAGCCCACAGAACCAGAAATAGAGGCGAGGCCGAGGCTGGCT
GCCGAGTCTGTATAA
|
Protein Properties |
Number of Residues
| 504 |
Molecular Weight
| 52318.2 |
Theoretical pI
| 5.32 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["15-35", "59-79", "86-106", "116-136", "144-164", "173-193", "255-275", "290-310", "319-335", "343-363", "377-397", "411-431"]
|
Protein Sequence
|
>Monocarboxylate transporter 3
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWV
SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTG
LGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLL
GGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRR
RLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDI
VARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMV
GALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEV
ALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALE
VLSARGEPTEPEIEARPRLAAESV
|
External Links |
GenBank ID Protein
| 6103363 |
UniProtKB/Swiss-Prot ID
| O95907 |
UniProtKB/Swiss-Prot Entry Name
| MOT3_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF132610 |
GeneCard ID
| SLC16A8 |
GenAtlas ID
| SLC16A8 |
HGNC ID
| HGNC:16270 |
References |
General References
| Not Available |