Record Information
Version1.0
Created at2020-04-17 18:40:01 UTC
Updated at2020-12-07 19:11:01 UTC
CannabisDB IDCDB004819
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameOxoglutaric acid
DescriptionOxoglutaric acid, also known as oxoglutarate or alpha-ketoglutarate, belongs to the class of organic compounds known as gamma-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the C4 carbon atom. Oxoglutaric acid is an extremely weak basic (essentially neutral) compound (based on its pKa). Oxoglutaric acid exists in all living species, ranging from bacteria to humans. Within humans, oxoglutaric acid participates in a number of enzymatic reactions. In particular, oxoglutaric acid can be biosynthesized from isocitric acid; which is mediated by the enzyme isocitrate dehydrogenase. In addition, oxoglutaric acid can be converted into succinyl-CoA; which is mediated by the enzyme oxoglutarate dehydrogenase complex. In humans, oxoglutaric acid is involved in the oncogenic action of fumarate. Oxoglutaric acid is an odorless tasting compound. Outside of the human body, Oxoglutaric acid is found, on average, in the highest concentration within star fruits and milk (cow). Oxoglutaric acid has also been detected, but not quantified in, several different foods, such as common chokecherries, red beetroots, adzuki beans, buffalo currants, and grapefruit/pummelo hybrids. This could make oxoglutaric acid a potential biomarker for the consumption of these foods. Oxoglutaric acid is a potentially toxic compound. An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. Oxoglutaric acid is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
2-Ketoglutaric acidChEBI
alpha-Ketoglutaric acidChEBI
2-KetoglutarateGenerator
a-KetoglutarateGenerator
a-Ketoglutaric acidGenerator
alpha-KetoglutarateGenerator
Α-ketoglutarateGenerator
Α-ketoglutaric acidGenerator
OxoglutarateGenerator
2-oxo-1,5-PentanedioateHMDB
2-oxo-1,5-Pentanedioic acidHMDB
2-OxoglutarateHMDB
2-Oxoglutaric acidHMDB
2-OxopentanedioateHMDB
2-Oxopentanedioic acidHMDB
alpha-OxoglutarateHMDB
Oxogluric acidHMDB
2 Oxoglutaric acidHMDB
Ketoglutaric acidHMDB
alpha Ketoglutaric acidHMDB
2 Ketoglutaric acidHMDB
alpha KetoglutarateHMDB
alpha OxoglutarateHMDB
2 KetoglutarateHMDB
2 OxoglutarateHMDB
alpha-Oxoglutaric acidHMDB
alpha-Oxopentanedioic acidHMDB
alpha-Keto-glutaric acidHMDB
Α-oxoglutaric acidHMDB
Α-oxopentanedioic acidHMDB
Α-keto-glutaric acidHMDB
Chemical FormulaC5H6O5
Average Molecular Weight146.1
Monoisotopic Molecular Weight146.0215
IUPAC Name2-oxopentanedioic acid
Traditional Nameoxoglutarate
CAS Registry Number328-50-7
SMILES
OC(=O)CCC(=O)C(O)=O
InChI Identifier
InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChI KeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as gamma-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the C4 carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassKeto acids and derivatives
Sub ClassGamma-keto acids and derivatives
Direct ParentGamma-keto acids and derivatives
Alternative Parents
Substituents
  • Gamma-keto acid
  • Short-chain keto acid
  • Dicarboxylic acid or derivatives
  • Alpha-keto acid
  • Alpha-hydroxy ketone
  • Ketone
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Biological role:

Industrial application:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point115.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility541.5 mg/mLNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.6ALOGPS
logP-0.11ChemAxon
logS-0.44ALOGPS
pKa (Strongest Acidic)2.66ChemAxon
pKa (Strongest Basic)-9.7ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area91.67 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity28.88 m³·mol⁻¹ChemAxon
Polarizability12.17 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-0fba-9200000000-4e367c66e94c51eb1a1bSpectrum
GC-MSOxoglutaric acid, 2 TMS, GC-MS Spectrumsplash10-000b-3910000000-4097b7eb52c2910a4277Spectrum
GC-MSOxoglutaric acid, non-derivatized, GC-MS Spectrumsplash10-0002-1910000000-3277227b9c4da4baa1f7Spectrum
GC-MSOxoglutaric acid, 2 TMS; 1 MEOX, GC-MS Spectrumsplash10-00di-9300000000-974bce546caa4fbe6b0fSpectrum
GC-MSOxoglutaric acid, 1 MEOX; 2 TMS, GC-MS Spectrumsplash10-000i-9710000000-d0aea11e947b042571f9Spectrum
GC-MSOxoglutaric acid, 1 MEOX; 2 TMS, GC-MS Spectrumsplash10-052s-4920000000-bf7ed92c68fd4c8dbb6bSpectrum
GC-MSOxoglutaric acid, non-derivatized, GC-MS Spectrumsplash10-000b-3910000000-4097b7eb52c2910a4277Spectrum
GC-MSOxoglutaric acid, non-derivatized, GC-MS Spectrumsplash10-0002-1910000000-3277227b9c4da4baa1f7Spectrum
GC-MSOxoglutaric acid, non-derivatized, GC-MS Spectrumsplash10-00di-9300000000-974bce546caa4fbe6b0fSpectrum
GC-MSOxoglutaric acid, non-derivatized, GC-MS Spectrumsplash10-000i-9710000000-d0aea11e947b042571f9Spectrum
GC-MSOxoglutaric acid, non-derivatized, GC-MS Spectrumsplash10-052s-4920000000-bf7ed92c68fd4c8dbb6bSpectrum
GC-MSOxoglutaric acid, non-derivatized, GC-MS Spectrumsplash10-000b-2900000000-e514f7afea2490bbe9edSpectrum
Predicted GC-MSOxoglutaric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0kfx-9200000000-0ee77a39e9862659f8a7Spectrum
Predicted GC-MSOxoglutaric acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00di-9730000000-5e17bd8cfd944963c79fSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)splash10-0zfr-6900000000-7fc343a243ce5d2a4f39Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)splash10-0a4i-9200000000-1a7af9946604baa8b3d2Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)splash10-0a4l-9800000000-30495b2afdd3526854e7Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0925200000-af33449c9638276466c2Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0a4i-9000000000-6e43f767847790112b65Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03di-0900000000-4cacc41705b7b385e91eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0udi-0900000000-1367eeeb6ad64c67a0aaSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-000t-0915051100-91cda631ee54800322b8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0a4i-9000000000-4f842c3673925d29c402Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0udi-0900000000-5e751351656f6eb62de3Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0910000000-7729faa24733fbad77b7Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-0002-0900000000-c3c62f83bff99f44f7abSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-0zfr-6900000000-b6d8379db3e3f1480b14Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-0a4i-9300000000-4fde39bb93cde5a27f23Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-00i0-9000000000-4343832f3a55842423a9Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004i-2900000000-5aa3d6d620db1d733a65Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0m30-7900000000-fc77f69ad43f915bf23eSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a6r-9000000000-c597f1f5e416037aa82dSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004i-2900000000-5aa3d6d620db1d733a65Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0m30-7900000000-fc77f69ad43f915bf23eSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a6r-9000000000-c597f1f5e416037aa82dSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-1900000000-f2b463076a150a514f0cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0f9t-8900000000-b2d3fa8d7ab01a220d9aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-053r-9100000000-554bfbd6839bc376cba0Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-1900000000-f2b463076a150a514f0cSpectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Dihydrolipoyl dehydrogenase, mitochondrialDLD7q31-q32P09622 details
4-aminobutyrate aminotransferase, mitochondrialABAT16p13.2P80404 details
Phytanoyl-CoA dioxygenase, peroxisomalPHYH10p13O14832 details
Tyrosine aminotransferaseTAT16q22.1P17735 details
Aspartate aminotransferase, cytoplasmicGOT110q24.1-q25.1P17174 details
Aspartate aminotransferase, mitochondrialGOT216q21P00505 details
Aldehyde dehydrogenase, mitochondrialALDH212q24.2P05091 details
Fatty aldehyde dehydrogenaseALDH3A217p11.2P51648 details
Aldehyde dehydrogenase X, mitochondrialALDH1B19p11.1P30837 details
Branched-chain-amino-acid aminotransferase, cytosolicBCAT112p12.1P54687 details
Prolyl 4-hydroxylase subunit alpha-2P4HA25q31O15460 details
Prolyl 4-hydroxylase subunit alpha-1P4HA110q21.3-q23.1P13674 details
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialAADAT4q33Q8N5Z0 details
Gamma-butyrobetaine dioxygenaseBBOX111p14.2O75936 details
Alanine--glyoxylate aminotransferase 2, mitochondrialAGXT25p13Q9BYV1 details
Ornithine aminotransferase, mitochondrialOAT10q26P04181 details
2-oxoglutarate dehydrogenase, mitochondrialOGDH7p14-p13Q02218 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1PLOD11p36.22Q02809 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2PLOD23q24O00469 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3PLOD37q22O60568 details
Kynurenine--oxoglutarate transaminase 1CCBL19q34.11Q16773 details
Branched-chain-amino-acid aminotransferase, mitochondrialBCAT219q13O15382 details
Glutamate dehydrogenase 2, mitochondrialGLUD2Xq24-q25P49448 details
Glutamate dehydrogenase 1, mitochondrialGLUD110q23.3P00367 details
Serine--pyruvate aminotransferaseAGXT2q37.3P21549 details
Alanine aminotransferase 1GPT8q24.3P24298 details
Phosphoserine aminotransferasePSAT19q21.2Q9Y617 details
Alpha-aminoadipic semialdehyde synthase, mitochondrialAASS7q31.3Q9UDR5 details
Isocitrate dehydrogenase [NADP], mitochondrialIDH215q26.1P48735 details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialIDH3B20p13O43837 details
Isocitrate dehydrogenase [NADP] cytoplasmicIDH12q33.3O75874 details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIDH3A15q25.1-q25.2P50213 details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialIDH3GXq28P51553 details
D-3-phosphoglycerate dehydrogenasePHGDH1p12O43175 details
Aspartyl/asparaginyl beta-hydroxylaseASPH8q12.1Q12797 details
Mitochondrial 2-oxoglutarate/malate carrier proteinSLC25A1117p13.3Q02978 details
D-2-hydroxyglutarate dehydrogenase, mitochondrialD2HGDH2q37.3Q8N465 details
L-2-hydroxyglutarate dehydrogenase, mitochondrialL2HGDH14q21.3Q9H9P8 details
Aminoadipate aminotransferase, isoform CRA_bAADAT4q33Q4W5N8 details
Trimethyllysine dioxygenase, mitochondrialTMLHEXq28Q9NVH6 details
Alanine aminotransferase 2GPT216q12.1Q8TD30 details
Hydroxyacid-oxoacid transhydrogenase, mitochondrialADHFE18q13.1Q8IWW8 details
Aminoadipate-semialdehyde synthaseAASS7q31.3A4D0W4 details
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2ALKBH212q24.11Q6NS38 details
Prolyl 3-hydroxylase 1LEPRE11p34.1Q32P28 details
Prolyl 3-hydroxylase 2LEPREL13q28Q8IVL5 details
Prolyl 3-hydroxylase 3LEPREL212q13Q8IVL6 details
Putative aspartate aminotransferase, cytoplasmic 2GOT1L18p11.23Q8NHS2 details
Kynurenine--oxoglutarate transaminase 3CCBL21p22.2Q6YP21 details
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialDHTKD110p14Q96HY7 details
2-oxoglutarate dehydrogenase-like, mitochondrialOGDHLQ9ULD0 details
Prolyl 4-hydroxylase subunit alpha-3P4HA311q13.4Q7Z4N8 details
Lysine-specific demethylase 2AKDM2A11q13.2Q9Y2K7 details
Lysine-specific demethylase 2BKDM2B12q24.31Q8NHM5 details
Egl nine homolog 1EGLN11q42.1Q9GZT9 details
Egl nine homolog 2EGLN219q13.2Q96KS0 details
Egl nine homolog 3EGLN314q13.1Q9H6Z9 details
Transmembrane prolyl 4-hydroxylaseP4HTM3p21.3Q9NXG6 details
Lysine-specific demethylase 8KDM816p12.1Q8N371 details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINAMINA3q11.2Q8IUF8 details
Omega-amidase NIT2NIT23q12.2Q9NQR4 details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66NO6614q24.3Q9H6W3 details
Histone lysine demethylase PHF8PHF8Xp11.22Q9UPP1 details
Methylcytosine dioxygenase TET1TET110q21Q8NFU7 details
Methylcytosine dioxygenase TET2TET24q24Q6N021 details
Methylcytosine dioxygenase TET3TET32p13.1O43151 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Mitochondrial 2-oxoglutarate/malate carrier proteinSLC25A1117p13.3Q02978 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Phytanoyl-CoA dioxygenase, peroxisomalPHYH10p13O14832 details
Prolyl 4-hydroxylase subunit alpha-2P4HA25q31O15460 details
Prolyl 4-hydroxylase subunit alpha-1P4HA110q21.3-q23.1P13674 details
Gamma-butyrobetaine dioxygenaseBBOX111p14.2O75936 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1PLOD11p36.22Q02809 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2PLOD23q24O00469 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3PLOD37q22O60568 details
Isocitrate dehydrogenase [NADP], mitochondrialIDH215q26.1P48735 details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialIDH3B20p13O43837 details
Isocitrate dehydrogenase [NADP] cytoplasmicIDH12q33.3O75874 details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIDH3A15q25.1-q25.2P50213 details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialIDH3GXq28P51553 details
Trimethyllysine dioxygenase, mitochondrialTMLHEXq28Q9NVH6 details
Hydroxyacid-oxoacid transhydrogenase, mitochondrialADHFE18q13.1Q8IWW8 details
Prolyl 3-hydroxylase 1LEPRE11p34.1Q32P28 details
Prolyl 3-hydroxylase 2LEPREL13q28Q8IVL5 details
Prolyl 3-hydroxylase 3LEPREL212q13Q8IVL6 details
Prolyl 4-hydroxylase subunit alpha-3P4HA311q13.4Q7Z4N8 details
Lysine-specific demethylase 2AKDM2A11q13.2Q9Y2K7 details
Lysine-specific demethylase 2BKDM2B12q24.31Q8NHM5 details
Egl nine homolog 1EGLN11q42.1Q9GZT9 details
Egl nine homolog 2EGLN219q13.2Q96KS0 details
Egl nine homolog 3EGLN314q13.1Q9H6Z9 details
Transmembrane prolyl 4-hydroxylaseP4HTM3p21.3Q9NXG6 details
Lysine-specific demethylase 8KDM816p12.1Q8N371 details
Methylcytosine dioxygenase TET2TET24q24Q6N021 details
Methylcytosine dioxygenase TET3TET32p13.1O43151 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Egl nine homolog 2EGLN219q13.2Q96KS0 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Aspartyl/asparaginyl beta-hydroxylaseASPH8q12.1Q12797 details
Hypoxia-inducible factor 1-alpha inhibitorHIF1AN10q24Q9NWT6 details
Lysine-specific demethylase 2AKDM2A11q13.2Q9Y2K7 details
Lysine-specific demethylase 2BKDM2B12q24.31Q8NHM5 details
Egl nine homolog 1EGLN11q42.1Q9GZT9 details
Egl nine homolog 2EGLN219q13.2Q96KS0 details
Egl nine homolog 3EGLN314q13.1Q9H6Z9 details
Lysine-specific demethylase 8KDM816p12.1Q8N371 details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66NO6614q24.3Q9H6W3 details
Histone lysine demethylase PHF8PHF8Xp11.22Q9UPP1 details
Methylcytosine dioxygenase TET1TET110q21Q8NFU7 details
Concentrations Data
Not Available
HMDB IDHMDB0000208
DrugBank IDDB08845
Phenol Explorer Compound IDNot Available
FoodDB IDFDB003361
KNApSAcK IDC00000769
Chemspider ID50
KEGG Compound IDC00026
BioCyc ID2-KETOGLUTARATE
BiGG ID33565
Wikipedia LinkAlpha-Ketoglutaric_acid
METLIN ID5218
PubChem Compound51
PDB IDNot Available
ChEBI ID30915
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 106 proteins in total.

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Gene Name:
DLD
Uniprot ID:
P09622
Molecular weight:
54176.91
General function:
Involved in 4-aminobutyrate transaminase activity
Specific function:
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:
ABAT
Uniprot ID:
P80404
Molecular weight:
56438.405
General function:
Involved in electron carrier activity
Specific function:
Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
Gene Name:
PHYH
Uniprot ID:
O14832
Molecular weight:
38538.065
General function:
Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Gene Name:
TAT
Uniprot ID:
P17735
Molecular weight:
50398.895
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Plays a key role in amino acid metabolism (By similarity).
Gene Name:
GOT1
Uniprot ID:
P17174
Molecular weight:
46247.14
General function:
Involved in transferase activity, transferring nitrogenous groups
Specific function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:
GOT2
Uniprot ID:
P00505
Molecular weight:
47517.285
General function:
Involved in oxidoreductase activity
Specific function:
Not Available
Gene Name:
ALDH2
Uniprot ID:
P05091
Molecular weight:
56380.93
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Gene Name:
ALDH3A2
Uniprot ID:
P51648
Molecular weight:
54847.36
General function:
Involved in oxidoreductase activity
Specific function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Gene Name:
ALDH1B1
Uniprot ID:
P30837
Molecular weight:
57248.96
General function:
Involved in catalytic activity
Specific function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Gene Name:
BCAT1
Uniprot ID:
P54687
Molecular weight:
38644.77

Transporters

General function:
Involved in transporter activity
Specific function:
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
Gene Name:
SLC25A11
Uniprot ID:
Q02978
Molecular weight:
34061.405

Only showing the first 10 proteins. There are 106 proteins in total.