Cannabis Compound Database: Showing Compound Card for Oxoglutaric acid (CDB004819)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (66)transporters (1) Show 106 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:40:01 UTC

Updated at

2020-12-07 19:11:01 UTC

CannabisDB ID

CDB004819

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Oxoglutaric acid

Description

Oxoglutaric acid, also known as oxoglutarate or alpha-ketoglutarate, belongs to the class of organic compounds known as gamma-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the C4 carbon atom. Oxoglutaric acid is an extremely weak basic (essentially neutral) compound (based on its pKa). Oxoglutaric acid exists in all living species, ranging from bacteria to humans. Within humans, oxoglutaric acid participates in a number of enzymatic reactions. In particular, oxoglutaric acid can be biosynthesized from isocitric acid; which is mediated by the enzyme isocitrate dehydrogenase. In addition, oxoglutaric acid can be converted into succinyl-CoA; which is mediated by the enzyme oxoglutarate dehydrogenase complex. In humans, oxoglutaric acid is involved in the oncogenic action of fumarate. Oxoglutaric acid is an odorless tasting compound. Outside of the human body, Oxoglutaric acid is found, on average, in the highest concentration within star fruits and milk (cow). Oxoglutaric acid has also been detected, but not quantified in, several different foods, such as common chokecherries, red beetroots, adzuki beans, buffalo currants, and grapefruit/pummelo hybrids. This could make oxoglutaric acid a potential biomarker for the consumption of these foods. Oxoglutaric acid is a potentially toxic compound. An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. Oxoglutaric acid is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
2-Ketoglutaric acid	ChEBI
alpha-Ketoglutaric acid	ChEBI
2-Ketoglutarate	Generator
a-Ketoglutarate	Generator
a-Ketoglutaric acid	Generator
alpha-Ketoglutarate	Generator
Α-ketoglutarate	Generator
Α-ketoglutaric acid	Generator
Oxoglutarate	Generator
2-oxo-1,5-Pentanedioate	HMDB
2-oxo-1,5-Pentanedioic acid	HMDB
2-Oxoglutarate	HMDB
2-Oxoglutaric acid	HMDB
2-Oxopentanedioate	HMDB
2-Oxopentanedioic acid	HMDB
alpha-Oxoglutarate	HMDB
Oxogluric acid	HMDB
2 Oxoglutaric acid	HMDB
Ketoglutaric acid	HMDB
alpha Ketoglutaric acid	HMDB
2 Ketoglutaric acid	HMDB
alpha Ketoglutarate	HMDB
alpha Oxoglutarate	HMDB
2 Ketoglutarate	HMDB
2 Oxoglutarate	HMDB
alpha-Oxoglutaric acid	HMDB
alpha-Oxopentanedioic acid	HMDB
alpha-Keto-glutaric acid	HMDB
Α-oxoglutaric acid	HMDB
Α-oxopentanedioic acid	HMDB
Α-keto-glutaric acid	HMDB

Chemical Formula

C₅H₆O₅

Average Molecular Weight

146.1

Monoisotopic Molecular Weight

146.0215

IUPAC Name

2-oxopentanedioic acid

Traditional Name

oxoglutarate

CAS Registry Number

328-50-7

SMILES

OC(=O)CCC(=O)C(O)=O

InChI Identifier

InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI Key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as gamma-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the C4 carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Keto acids and derivatives

Sub Class

Gamma-keto acids and derivatives

Direct Parent

Gamma-keto acids and derivatives

Alternative Parents

Substituents

Gamma-keto acid
Short-chain keto acid
Dicarboxylic acid or derivatives
Alpha-keto acid
Alpha-hydroxy ketone
Ketone
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

oxo dicarboxylic acid (CHEBI:30915 )

Ontology

Ingestion

Source:

Biological:

Animal

Fungi:

Yeast

Microbe:

Corynebacterium:

Corynebacterium glutamicum

Plant:

Biological location:

Tissue and substructures:

Placenta

Biofluid and excreta:

Cell and elements:

Extracellular

Subcellular:

Role

Biological role:

Metabolite

Industrial application:

Food and nutrition

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	115.5 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	541.5 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.6	ALOGPS
logP	-0.11	ChemAxon
logS	-0.44	ALOGPS
pKa (Strongest Acidic)	2.66	ChemAxon
pKa (Strongest Basic)	-9.7	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	91.67 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	28.88 m³·mol⁻¹	ChemAxon
Polarizability	12.17 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-0fba-9200000000-4e367c66e94c51eb1a1b	2014-09-20	View Spectrum
GC-MS	Oxoglutaric acid, 2 TMS, GC-MS Spectrum	splash10-000b-3910000000-4097b7eb52c2910a4277	Spectrum
GC-MS	Oxoglutaric acid, non-derivatized, GC-MS Spectrum	splash10-0002-1910000000-3277227b9c4da4baa1f7	Spectrum
GC-MS	Oxoglutaric acid, 2 TMS; 1 MEOX, GC-MS Spectrum	splash10-00di-9300000000-974bce546caa4fbe6b0f	Spectrum
GC-MS	Oxoglutaric acid, 1 MEOX; 2 TMS, GC-MS Spectrum	splash10-000i-9710000000-d0aea11e947b042571f9	Spectrum
GC-MS	Oxoglutaric acid, 1 MEOX; 2 TMS, GC-MS Spectrum	splash10-052s-4920000000-bf7ed92c68fd4c8dbb6b	Spectrum
GC-MS	Oxoglutaric acid, non-derivatized, GC-MS Spectrum	splash10-000b-3910000000-4097b7eb52c2910a4277	Spectrum
GC-MS	Oxoglutaric acid, non-derivatized, GC-MS Spectrum	splash10-0002-1910000000-3277227b9c4da4baa1f7	Spectrum
GC-MS	Oxoglutaric acid, non-derivatized, GC-MS Spectrum	splash10-00di-9300000000-974bce546caa4fbe6b0f	Spectrum
GC-MS	Oxoglutaric acid, non-derivatized, GC-MS Spectrum	splash10-000i-9710000000-d0aea11e947b042571f9	Spectrum
GC-MS	Oxoglutaric acid, non-derivatized, GC-MS Spectrum	splash10-052s-4920000000-bf7ed92c68fd4c8dbb6b	Spectrum
GC-MS	Oxoglutaric acid, non-derivatized, GC-MS Spectrum	splash10-000b-2900000000-e514f7afea2490bbe9ed	Spectrum
Predicted GC-MS	Oxoglutaric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0kfx-9200000000-0ee77a39e9862659f8a7	Spectrum
Predicted GC-MS	Oxoglutaric acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00di-9730000000-5e17bd8cfd944963c79f	Spectrum
Predicted GC-MS	Oxoglutaric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TBDMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Oxoglutaric acid, TBDMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)	splash10-0zfr-6900000000-7fc343a243ce5d2a4f39	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)	splash10-0a4i-9200000000-1a7af9946604baa8b3d2	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)	splash10-0a4l-9800000000-30495b2afdd3526854e7	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0925200000-af33449c9638276466c2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-9000000000-6e43f767847790112b65	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-4cacc41705b7b385e91e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0900000000-1367eeeb6ad64c67a0aa	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-000t-0915051100-91cda631ee54800322b8	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-9000000000-4f842c3673925d29c402	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0900000000-5e751351656f6eb62de3	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0910000000-7729faa24733fbad77b7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0900000000-c3c62f83bff99f44f7ab	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0zfr-6900000000-b6d8379db3e3f1480b14	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0a4i-9300000000-4fde39bb93cde5a27f23	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-00i0-9000000000-4343832f3a55842423a9	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-004i-2900000000-5aa3d6d620db1d733a65	2015-05-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0m30-7900000000-fc77f69ad43f915bf23e	2015-05-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0a6r-9000000000-c597f1f5e416037aa82d	2015-05-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-004i-2900000000-5aa3d6d620db1d733a65	2015-05-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0m30-7900000000-fc77f69ad43f915bf23e	2015-05-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0a6r-9000000000-c597f1f5e416037aa82d	2015-05-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-1900000000-f2b463076a150a514f0c	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0f9t-8900000000-b2d3fa8d7ab01a220d9a	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-053r-9100000000-554bfbd6839bc376cba0	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-1900000000-f2b463076a150a514f0c	2015-05-27	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, DMSO-d6, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100.54 MHz, DMSO-d6, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Citric Acid Cycle
Gluconeogenesis
Glutamate Metabolism
Urea Cycle
Glucose-Alanine Cycle		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Dihydrolipoyl dehydrogenase, mitochondrial	DLD	7q31-q32	P09622	details
4-aminobutyrate aminotransferase, mitochondrial	ABAT	16p13.2	P80404	details
Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	10p13	O14832	details
Tyrosine aminotransferase	TAT	16q22.1	P17735	details
Aspartate aminotransferase, cytoplasmic	GOT1	10q24.1-q25.1	P17174	details
Aspartate aminotransferase, mitochondrial	GOT2	16q21	P00505	details
Aldehyde dehydrogenase, mitochondrial	ALDH2	12q24.2	P05091	details
Fatty aldehyde dehydrogenase	ALDH3A2	17p11.2	P51648	details
Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	9p11.1	P30837	details
Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	12p12.1	P54687	details
Prolyl 4-hydroxylase subunit alpha-2	P4HA2	5q31	O15460	details
Prolyl 4-hydroxylase subunit alpha-1	P4HA1	10q21.3-q23.1	P13674	details
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	AADAT	4q33	Q8N5Z0	details
Gamma-butyrobetaine dioxygenase	BBOX1	11p14.2	O75936	details
Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	5p13	Q9BYV1	details
Ornithine aminotransferase, mitochondrial	OAT	10q26	P04181	details
2-oxoglutarate dehydrogenase, mitochondrial	OGDH	7p14-p13	Q02218	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Kynurenine--oxoglutarate transaminase 1	CCBL1	9q34.11	Q16773	details
Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	19q13	O15382	details
Glutamate dehydrogenase 2, mitochondrial	GLUD2	Xq24-q25	P49448	details
Glutamate dehydrogenase 1, mitochondrial	GLUD1	10q23.3	P00367	details
Serine--pyruvate aminotransferase	AGXT	2q37.3	P21549	details
Alanine aminotransferase 1	GPT	8q24.3	P24298	details
Phosphoserine aminotransferase	PSAT1	9q21.2	Q9Y617	details
Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	7q31.3	Q9UDR5	details
Isocitrate dehydrogenase [NADP], mitochondrial	IDH2	15q26.1	P48735	details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	20p13	O43837	details
Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	2q33.3	O75874	details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	15q25.1-q25.2	P50213	details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	Xq28	P51553	details
D-3-phosphoglycerate dehydrogenase	PHGDH	1p12	O43175	details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details
Mitochondrial 2-oxoglutarate/malate carrier protein	SLC25A11	17p13.3	Q02978	details
D-2-hydroxyglutarate dehydrogenase, mitochondrial	D2HGDH	2q37.3	Q8N465	details
L-2-hydroxyglutarate dehydrogenase, mitochondrial	L2HGDH	14q21.3	Q9H9P8	details
Aminoadipate aminotransferase, isoform CRA_b	AADAT	4q33	Q4W5N8	details
Trimethyllysine dioxygenase, mitochondrial	TMLHE	Xq28	Q9NVH6	details
Alanine aminotransferase 2	GPT2	16q12.1	Q8TD30	details
Hydroxyacid-oxoacid transhydrogenase, mitochondrial	ADHFE1	8q13.1	Q8IWW8	details
Aminoadipate-semialdehyde synthase	AASS	7q31.3	A4D0W4	details
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2	ALKBH2	12q24.11	Q6NS38	details
Prolyl 3-hydroxylase 1	LEPRE1	1p34.1	Q32P28	details
Prolyl 3-hydroxylase 2	LEPREL1	3q28	Q8IVL5	details
Prolyl 3-hydroxylase 3	LEPREL2	12q13	Q8IVL6	details
Putative aspartate aminotransferase, cytoplasmic 2	GOT1L1	8p11.23	Q8NHS2	details
Kynurenine--oxoglutarate transaminase 3	CCBL2	1p22.2	Q6YP21	details
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial	DHTKD1	10p14	Q96HY7	details
2-oxoglutarate dehydrogenase-like, mitochondrial	OGDHL		Q9ULD0	details
Prolyl 4-hydroxylase subunit alpha-3	P4HA3	11q13.4	Q7Z4N8	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details
Egl nine homolog 1	EGLN1	1q42.1	Q9GZT9	details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details
Egl nine homolog 3	EGLN3	14q13.1	Q9H6Z9	details
Transmembrane prolyl 4-hydroxylase	P4HTM	3p21.3	Q9NXG6	details
Lysine-specific demethylase 8	KDM8	16p12.1	Q8N371	details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA	MINA	3q11.2	Q8IUF8	details
Omega-amidase NIT2	NIT2	3q12.2	Q9NQR4	details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66	NO66	14q24.3	Q9H6W3	details
Histone lysine demethylase PHF8	PHF8	Xp11.22	Q9UPP1	details
Methylcytosine dioxygenase TET1	TET1	10q21	Q8NFU7	details
Methylcytosine dioxygenase TET2	TET2	4q24	Q6N021	details
Methylcytosine dioxygenase TET3	TET3	2p13.1	O43151	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Mitochondrial 2-oxoglutarate/malate carrier protein	SLC25A11	17p13.3	Q02978	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	10p13	O14832	details
Prolyl 4-hydroxylase subunit alpha-2	P4HA2	5q31	O15460	details
Prolyl 4-hydroxylase subunit alpha-1	P4HA1	10q21.3-q23.1	P13674	details
Gamma-butyrobetaine dioxygenase	BBOX1	11p14.2	O75936	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Isocitrate dehydrogenase [NADP], mitochondrial	IDH2	15q26.1	P48735	details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	20p13	O43837	details
Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	2q33.3	O75874	details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	15q25.1-q25.2	P50213	details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	Xq28	P51553	details
Trimethyllysine dioxygenase, mitochondrial	TMLHE	Xq28	Q9NVH6	details
Hydroxyacid-oxoacid transhydrogenase, mitochondrial	ADHFE1	8q13.1	Q8IWW8	details
Prolyl 3-hydroxylase 1	LEPRE1	1p34.1	Q32P28	details
Prolyl 3-hydroxylase 2	LEPREL1	3q28	Q8IVL5	details
Prolyl 3-hydroxylase 3	LEPREL2	12q13	Q8IVL6	details
Prolyl 4-hydroxylase subunit alpha-3	P4HA3	11q13.4	Q7Z4N8	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details
Egl nine homolog 1	EGLN1	1q42.1	Q9GZT9	details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details
Egl nine homolog 3	EGLN3	14q13.1	Q9H6Z9	details
Transmembrane prolyl 4-hydroxylase	P4HTM	3p21.3	Q9NXG6	details
Lysine-specific demethylase 8	KDM8	16p12.1	Q8N371	details
Methylcytosine dioxygenase TET2	TET2	4q24	Q6N021	details
Methylcytosine dioxygenase TET3	TET3	2p13.1	O43151	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details
Hypoxia-inducible factor 1-alpha inhibitor	HIF1AN	10q24	Q9NWT6	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details
Egl nine homolog 1	EGLN1	1q42.1	Q9GZT9	details
Egl nine homolog 2	EGLN2	19q13.2	Q96KS0	details
Egl nine homolog 3	EGLN3	14q13.1	Q9H6Z9	details
Lysine-specific demethylase 8	KDM8	16p12.1	Q8N371	details
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66	NO66	14q24.3	Q9H6W3	details
Histone lysine demethylase PHF8	PHF8	Xp11.22	Q9UPP1	details
Methylcytosine dioxygenase TET1	TET1	10q21	Q8NFU7	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000208

DrugBank ID

DB08845

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB003361

KNApSAcK ID

C00000769

Chemspider ID

KEGG Compound ID

C00026

BioCyc ID

2-KETOGLUTARATE

BiGG ID

33565

Wikipedia Link

Alpha-Ketoglutaric_acid

METLIN ID

5218

PubChem Compound

PDB ID

Not Available

ChEBI ID

30915

References

General References

Not Available

Only showing the first 10 proteins. There are 106 proteins in total.

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Enzymes

Enzyme Details

1. Dihydrolipoyl dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Gene Name:: DLD
Uniprot ID:: P09622
Molecular weight:: 54176.91

Enzyme Details

2. 4-aminobutyrate aminotransferase, mitochondrial

General function:: Involved in 4-aminobutyrate transaminase activity
Specific function:: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:: ABAT
Uniprot ID:: P80404
Molecular weight:: 56438.405

Enzyme Details

3. Phytanoyl-CoA dioxygenase, peroxisomal

General function:: Involved in electron carrier activity
Specific function:: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
Gene Name:: PHYH
Uniprot ID:: O14832
Molecular weight:: 38538.065

Enzyme Details

4. Tyrosine aminotransferase

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Gene Name:: TAT
Uniprot ID:: P17735
Molecular weight:: 50398.895

Enzyme Details

5. Aspartate aminotransferase, cytoplasmic

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Plays a key role in amino acid metabolism (By similarity).
Gene Name:: GOT1
Uniprot ID:: P17174
Molecular weight:: 46247.14

Enzyme Details

6. Aspartate aminotransferase, mitochondrial

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:: GOT2
Uniprot ID:: P00505
Molecular weight:: 47517.285

Enzyme Details

7. Aldehyde dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Not Available
Gene Name:: ALDH2
Uniprot ID:: P05091
Molecular weight:: 56380.93

Enzyme Details

8. Fatty aldehyde dehydrogenase

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Gene Name:: ALDH3A2
Uniprot ID:: P51648
Molecular weight:: 54847.36

Enzyme Details

9. Aldehyde dehydrogenase X, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Gene Name:: ALDH1B1
Uniprot ID:: P30837
Molecular weight:: 57248.96

Enzyme Details

10. Branched-chain-amino-acid aminotransferase, cytosolic

General function:: Involved in catalytic activity
Specific function:: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Gene Name:: BCAT1
Uniprot ID:: P54687
Molecular weight:: 38644.77

Transporters

Enzyme Details

1. Mitochondrial 2-oxoglutarate/malate carrier protein

General function:: Involved in transporter activity
Specific function:: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
Gene Name:: SLC25A11
Uniprot ID:: Q02978
Molecular weight:: 34061.405

Only showing the first 10 proteins. There are 106 proteins in total.

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Showing Compound Card for Oxoglutaric acid (CDB004819)

Structure for CDB004819 (Oxoglutaric acid)

Enzymes

Transporters