Cannabis Compound Database: Showing Protein Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (CDBP04291)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP04291

Secondary Accession Numbers

Not Available

Name

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Description

Not Available

Synonyms

Dehydrogenase E1 and transketolase domain-containing protein 1

Gene Name

DHTKD1

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity

Specific Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

GO Classification

Biological Process
glycolysis
tricarboxylic acid cycle
Cellular Component
mitochondrion
Function
catalytic activity
vitamin binding
oxidoreductase activity
thiamin pyrophosphate binding
oxoglutarate dehydrogenase (succinyl-transferring) activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
binding
Molecular Function
oxoglutarate dehydrogenase (succinyl-transferring) activity
thiamine pyrophosphate binding
Process
glycolysis
metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
glucose metabolic process
glucose catabolic process

Cellular Location

Mitochondrion (Potential)

Pathways

Name	SMPDB/Pathwhiz	KEGG
Lysine Degradation
Saccharopinuria/Hyperlysinemia II		Not Available
Hyperlysinemia I, Familial		Not Available
Hyperlysinemia II or Saccharopinuria		Not Available
Pyridoxine dependency with seizures		Not Available

Gene Properties

Chromosome Location

Locus

10p14

SNPs

DHTKD1

Gene Sequence

>2760 bp
ATGGCCTCTGCTACTGCGGCAGCAGCACGACGGGGCCTCGGCCGGGCTCTCCCTCTCCTC
TGGCGTGGCTACCAGACCGAGCGGGGCGTTTACGGCTACCGGCCGAGGAAGCCCGAGAGC
CGCGAGCCCCAGGGCGCCCTGGAGCGCCCCCCAGTTGATCATGGCCTTGCCAGGTTGGTG
ACAGTATATTGTGAGCATGGTCATAAAGCTGCCAAAATCAACCCCCTCTTCACCGGACAA
GCCCTGCTGGAGAATGTGCCTGAAATCCAAGCCCTGGTGCAGACACTGCAGGGACCCTTC
CACACGGCAGGATTATTGAACATGGGGAAGGAAGAGGCCTCACTTGAGGAAGTGTTAGTC
TATCTCAATCAAATCTACTGTGGGCAGATTTCTATTGAAACCTCCCAACTTCAGAGCCAG
GATGAGAAAGACTGGTTTGCCAAGCGGTTTGAGGAACTGCAAAAGGAGACGTTTACCACA
GAAGAGCGAAAACATCTGTCGAAACTAATGCTGGAATCTCAGGAGTTTGACCACTTTCTG
GCCACCAAGTTCTCGACAGTGAAGCGATATGGAGGCGAAGGGGCTGAAAGCATGATGGGC
TTTTTCCACGAGCTGCTGAAAATGTCGGCCTACAGCGGGATCACTGATGTCATTATTGGG
ATGCCCCATAGAGGGAGGCTGAATTTATTGACAGGCCTTCTGCAGTTCCCTCCAGAGCTG
ATGTTCCGTAAAATGCGAGGCTTAAGTGAATTTCCAGAGAATTTCTCAGCCACTGGAGAC
GTCCTGTCTCACCTGACCTCCTCTGTGGACCTGTACTTTGGGGCGCACCATCCCCTCCAT
GTGACAATGTTGCCCAATCCCTCGCACCTGGAGGCCGTCAACCCCGTGGCCGTGGGCAAA
ACTCGCGGCAGGCAGCAGTCTCGCCAAGACGGCGATTACTCTCCAGACAACTCAGCCCAG
CCGGGGGACAGGGTCATTTGCTTACAGGTCCATGGTGATGCTTCTTTCTGTGGTCAAGGG
ATTGTTCCTGAAACATTCACGCTGTCCAATCTCCCACATTTCAGAATTGGTGGGAGTGTG
CATTTGATTGTTAATAACCAGCTGGGTTACACCACTCCAGCTGAAAGAGGAAGGTCTTCT
TTATACTGCAGTGATATTGGGAAGCTTGTGGGCTGTGCCATCATCCATGTCAATGGAGAC
AGCCCAGAGGAAGTGGTCCGTGCCACACGACTGGCTTTTGAATACCAACGCCAGTTCCGC
AAGGATGTGATTATTGATCTGTTGTGCTACAGGCAGTGGGGCCACAATGAGCTGGATGAG
CCATTCTACACCAACCCCATCATGTACAAAATCATCAGAGCTCGAAAGAGCATTCCAGAC
ACATATGCAGAGCACCTCATTGCTGGCGGACTCATGACGCAGGAGGAGGTGTCTGAAATA
AAATCCTCCTACTATGCCAAGTTGAATGATCACTTAAATAACATGGCCCACTACAGGCCC
CCTGCCCTGAACCTGCAGGCCCACTGGCAGGGCCTGGCTCAGCCAGAAGCGCAAATCACC
ACCTGGAGTACAGGTGTGCCCCTCGACCTCCTGCGGTTTGTTGGCATGAAGTCTGTAGAG
GTGCCAAGAGAGCTGCAGATGCACAGTCACCTGCTGAAGACACATGTTCAGTCCAGAATG
GAGAAGATGATGGACGGAATCAAGCTAGACTGGGCCACCGCGGAAGCTCTTGCCTTGGGT
TCTTTACTTGCTCAAGGTTTTAATGTTCGTCTAAGTGGCCAAGATGTTGGTCGTGGAACT
TTCAGTCAGAGGCATGCAATCGTGGTTTGCCAGGAGACGGATGACACCTACATCCCCCTG
AACCATATGGACCCAAATCAGAAGGGGTTTCTAGAGGTCAGCAACAGCCCCCTGTCAGAA
GAGGCCGTCCTGGGATTCGAATATGGGATGAGCATTGAGAGCCCAAAGTTACTGCCCCTG
TGGGAGGCACAGTTTGGCGATTTCTTCAATGGTGCCCAGATCATCTTTGACACATTCATC
TCTGGAGGAGAGGCCAAGTGGCTCCTACAAAGCGGCATCGTCATCCTCCTTCCACATGGC
TACGATGGGGCTGGGCCAGACCACTCATCCTGTCGAATAGAGCGTTTCCTGCAGATGTGT
GACAGTGCGGAAGAGGGGGTGGACGGAGACACTGTGAACATGTTTGTGGTTCACCCAACA
ACTCCTGCACAGTATTTCCACTTGCTTAGGAGACAGATGGTCCGGAACTTCAGAAAACCA
CTCATTGTTGCTTCCCCTAAGATGTTACTCAGGCTCCCGGCAGCCGTGTCAACTCTTCAA
GAAATGGCACCAGGAACAACATTTAACCCGGTCATTGGTGATTCATCTGTGGATCCAAAA
AAGGTTAAGACCCTCGTGTTCTGCTCCGGCAAACATTTCTACTCCCTGGTGAAACAAAGA
GAATCTCTGGGGGCCAAGAAGCATGACTTTGCCATCATCCGAGTAGAGGAACTCTGCCCC
TTCCCGTTGGATTCTTTACAGCAAGAGATGAGCAAATACAAACATGTTAAAGATCATATT
TGGAGTCAGGAGGAACCTCAGAACATGGGTCCGTGGTCGTTTGTTTCTCCAAGGTTTGAA
AAGCAGCTGGCCTGCAAGCTCCGTCTGGTGGGCCGGCCCCCTTTGCCAGTACCCGCTGTA
GGAATTGGCACAGTTCACTTGCACCAGCATGAAGATATCCTCGCCAAGACCTTCGCTTGA

Protein Properties

Number of Residues

919

Molecular Weight

103042.15

Theoretical pI

6.936

Pfam Domain Function

Transket_pyr (PF02779 )
E1_dh (PF00676 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
MASATAAAARRGLGRALPLFWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGLARLV
TVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLV
YLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFL
ATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPEL
MFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGK
TRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSV
HLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFR
KDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEI
KSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVE
VPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGT
FSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPL
WEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMC
DSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQ
EMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCP
FPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAV
GIGTVHLHQHEDILAKTFA

External Links

GenBank ID Protein

38788380

UniProtKB/Swiss-Prot ID

Q96HY7

UniProtKB/Swiss-Prot Entry Name

DHTK1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_018706.5

GeneCard ID