Record Information
Version1.0
Created at2020-04-17 19:08:19 UTC
Updated at2020-11-18 16:39:19 UTC
CannabisDB IDCDB005090
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NamePotassium
DescriptionPotassium, also known as K+ or potassium ion, belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. Potassium is a weakly acidic compound (based on its pKa). Potassium exists in all living species, ranging from bacteria to humans. In humans, potassium is involved in the metabolic disorder called the phenytoin (antiarrhythmic) action pathway. Outside of the human body, Potassium is found, on average, in the highest concentration within a few different foods, such as kombus, milk (cow), and garden tomato (var.) and in a lower concentration in yogurts, strawberries, and zwiebacks. Potassium has also been detected, but not quantified in, several different foods, such as sourdocks, half-highbush blueberries, wax apples, jostaberries, and medlars. This could make potassium a potential biomarker for the consumption of these foods. Potassium is a potentially toxic compound. Potassium is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
K(+)ChEBI
K+ChEBI
POTASSIUM ionChEBI
Potassium(1+)Kegg
Nabumeton aKegg
KaliumHMDB
Potassium (ion)HMDB
Potassium (k+)HMDB
Potassium cationHMDB
Potassium ion (k+)HMDB
Potassium ion (K1+)HMDB
Potassium ion(+)HMDB
Potassium ion(1+)HMDB
Potassium monocationHMDB
Potassium(+)HMDB
Potassium(1+) ionHMDB
Potassium(I) cationHMDB
Liver regeneration factor 1HMDB
LRF-1HMDB
LRF1 Transcription factorHMDB
Chemical FormulaK
Average Molecular Weight39.1
Monoisotopic Molecular Weight38.9637
IUPAC Namepotassium(1+) ion
Traditional Namepotassium(1+) ion
CAS Registry Number7440-09-7
SMILES
[K+]
InChI Identifier
InChI=1S/K/q+1
InChI KeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkali metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkali metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkali metal
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point63.2 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.2ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MSNot Available
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598Spectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrialBCKDHA19q13.1-q13.2P12694 details
S-adenosylmethionine synthase isoform type-2MAT2A2p11.2P31153 details
S-adenosylmethionine synthase isoform type-1MAT1A10q22Q00266 details
Pyruvate kinase isozymes M1/M2PKM15q22P14618 details
Pyruvate kinase isozymes R/LPKLR1q21P30613 details
Inosine-5'-monophosphate dehydrogenase 2IMPDH23p21.2P12268 details
Inosine-5'-monophosphate dehydrogenase 1IMPDH17q31.3-q32P20839 details
Pyridoxal kinasePDXK21q22.3O00764 details
Sodium/potassium-transporting ATPase subunit beta-3ATP1B33q23P54709 details
Sodium/potassium-transporting ATPase subunit beta-2ATP1B217p13.1P14415 details
Sodium/potassium-transporting ATPase subunit beta-1ATP1B11q24P05026 details
Potassium-transporting ATPase alpha chain 2ATP12A13q12.1-q12.3P54707 details
Sodium/potassium-transporting ATPase subunit alpha-1ATP1A11p21P05023 details
Sodium/potassium-transporting ATPase subunit alpha-3ATP1A319q13.31P13637 details
Potassium-transporting ATPase subunit betaATP4B13q34P51164 details
Potassium-transporting ATPase alpha chain 1ATP4A19q13.1P20648 details
Sodium/potassium-transporting ATPase subunit alpha-2ATP1A21q23.2P50993 details
Sodium/potassium-transporting ATPase subunit alpha-4ATP1A41q23.2Q13733 details
NADPH-dependent diflavin oxidoreductase 1NDOR19q34.3Q9UHB4 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Tubulin--tyrosine ligaseTTL2q13Q8NG68 details
Pyruvate kinaseQ16715 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Sodium/potassium-transporting ATPase subunit beta-3ATP1B33q23P54709 details
Sodium/potassium-transporting ATPase subunit beta-2ATP1B217p13.1P14415 details
Sodium/potassium-transporting ATPase subunit beta-1ATP1B11q24P05026 details
Potassium-transporting ATPase alpha chain 2ATP12A13q12.1-q12.3P54707 details
Protein ATP1B4ATP1B4Q9UN42 details
Sodium/potassium-transporting ATPase subunit alpha-1ATP1A11p21P05023 details
Sodium/potassium-transporting ATPase subunit alpha-3ATP1A319q13.31P13637 details
Potassium-transporting ATPase subunit betaATP4B13q34P51164 details
Potassium-transporting ATPase alpha chain 1ATP4A19q13.1P20648 details
Sodium/potassium-transporting ATPase subunit alpha-2ATP1A21q23.2P50993 details
Calcium-activated potassium channel subunit alpha-1KCNMA110q22.3Q12791 details
Potassium voltage-gated channel subfamily H member 2KCNH27q36.1Q12809 details
Inward rectifier potassium channel 2KCNJ217q24.3P63252 details
Potassium voltage-gated channel subfamily KQT member 1KCNQ111p15.5P51787 details
ATP-sensitive inward rectifier potassium channel 1KCNJ111q24P48048 details
ATP-sensitive inward rectifier potassium channel 11KCNJ1111p15.1Q14654 details
Sodium/potassium-transporting ATPase subunit alpha-4ATP1A41q23.2Q13733 details
Calcium-activated potassium channel subunit beta-3KCNMB33q26.3-q27Q9NPA1 details
Potassium voltage-gated channel subfamily E member 3KCNE311q13.4Q9Y6H6 details
Potassium voltage-gated channel subfamily H member 1KCNH11q32.2O95259 details
Potassium voltage-gated channel subfamily E member 1KCNE121q22.1-q22.2|21q22.12P15382 details
Potassium voltage-gated channel subfamily KQT member 2KCNQ220q13.3O43526 details
Potassium voltage-gated channel subfamily A member 1KCNA112p13.32Q09470 details
Potassium voltage-gated channel subfamily KQT member 3KCNQ38q24O43525 details
Potassium voltage-gated channel subfamily E member 2KCNE221q22.12Q9Y6J6 details
Potassium voltage-gated channel subfamily D member 2KCND27q31Q9NZV8 details
Potassium voltage-gated channel subfamily D member 3KCND31p13.3Q9UK17 details
Potassium voltage-gated channel subfamily KQT member 5KCNQ56q14Q9NR82 details
Potassium voltage-gated channel subfamily A member 4KCNA411p14P22459 details
Potassium voltage-gated channel subfamily A member 3KCNA31p13.3P22001 details
Potassium voltage-gated channel subfamily C member 3KCNC319q13.33Q14003 details
Potassium voltage-gated channel subfamily KQT member 4KCNQ41p34P56696 details
Potassium voltage-gated channel subfamily C member 4KCNC41p21Q03721 details
Potassium channel subfamily K member 1KCNK11q42-q43O00180 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrialBCKDHA19q13.1-q13.2P12694 details
S-adenosylmethionine synthase isoform type-2MAT2A2p11.2P31153 details
S-adenosylmethionine synthase isoform type-1MAT1A10q22Q00266 details
Pyruvate kinase isozymes M1/M2PKM15q22P14618 details
Pyruvate kinase isozymes R/LPKLR1q21P30613 details
Inosine-5'-monophosphate dehydrogenase 2IMPDH23p21.2P12268 details
Inosine-5'-monophosphate dehydrogenase 1IMPDH17q31.3-q32P20839 details
Potassium-transporting ATPase alpha chain 2ATP12A13q12.1-q12.3P54707 details
Sodium/potassium-transporting ATPase subunit alpha-1ATP1A11p21P05023 details
Sodium/potassium-transporting ATPase subunit alpha-3ATP1A319q13.31P13637 details
Potassium-transporting ATPase alpha chain 1ATP4A19q13.1P20648 details
Sodium/potassium-transporting ATPase subunit alpha-2ATP1A21q23.2P50993 details
Calcium-binding protein p22CHP15q13.3Q99653 details
CalsenilinKCNIP32q21.1Q9Y2W7 details
Steroidogenic factor 1NR5A19q33Q13285 details
Sodium/potassium-transporting ATPase subunit alpha-4ATP1A41q23.2Q13733 details
Kv channel-interacting protein 1KCNIP15q35.1Q9NZI2 details
Kv channel-interacting protein 2KCNIP210q24Q9NS61 details
NADPH-dependent diflavin oxidoreductase 1NDOR19q34.3Q9UHB4 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Pyruvate kinaseQ16715 details
Potassium voltage-gated channel subfamily A member 4KCNA411p14P22459 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Sodium/potassium-transporting ATPase subunit alpha-3ATP1A319q13.31P13637 details
Gamma-aminobutyric acid type B receptor subunit 1GABBR16p21.31Q9UBS5 details
Steroidogenic factor 1NR5A19q33Q13285 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Potassium voltage-gated channel subfamily H member 2KCNH27q36.1Q12809 details
Steroidogenic factor 1NR5A19q33Q13285 details
Potassium voltage-gated channel subfamily H member 1KCNH11q32.2O95259 details
Concentrations Data
Cannabis CultivarStatusValueReferenceDetails
Alien DawgDetected and Quantified46.935 mg/g dry wt
    • Jiamin Zheng, Yil...
details
GabriolaDetected and Quantified44.449 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Island HoneyDetected and Quantified41.741 mg/g dry wt
    • Jiamin Zheng, Yil...
details
QuadraDetected and Quantified36.899 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Sensi StarDetected and Quantified44.703 mg/g dry wt
    • Jiamin Zheng, Yil...
details
Tangerine DreamDetected and Quantified29.918 mg/g dry wt
    • Jiamin Zheng, Yil...
details
HMDB IDHMDB0000586
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB003521
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDC00238
BioCyc IDNot Available
BiGG ID34349
Wikipedia LinkPotassium
METLIN ID3197
PubChem Compound813
PDB IDNot Available
ChEBI ID29103
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 84 proteins in total.

Enzymes

General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:
BCKDHA
Uniprot ID:
P12694
Molecular weight:
50470.58
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT2A
Uniprot ID:
P31153
Molecular weight:
43660.37
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT1A
Uniprot ID:
Q00266
Molecular weight:
43647.6
General function:
Involved in magnesium ion binding
Specific function:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Gene Name:
PKM
Uniprot ID:
P14618
Molecular weight:
65930.14
General function:
Involved in magnesium ion binding
Specific function:
Plays a key role in glycolysis (By similarity).
Gene Name:
PKLR
Uniprot ID:
P30613
Molecular weight:
61829.575
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH2
Uniprot ID:
P12268
Molecular weight:
55804.495
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH1
Uniprot ID:
P20839
Molecular weight:
63252.24
General function:
Involved in pyridoxal kinase activity
Specific function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name:
PDXK
Uniprot ID:
O00764
Molecular weight:
35102.105
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known
Gene Name:
ATP1B3
Uniprot ID:
P54709
Molecular weight:
31512.3
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Gene Name:
ATP1B2
Uniprot ID:
P14415
Molecular weight:
33366.9

Transporters

General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known
Gene Name:
ATP1B3
Uniprot ID:
P54709
Molecular weight:
31512.3
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Gene Name:
ATP1B2
Uniprot ID:
P14415
Molecular weight:
33366.9
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane
Gene Name:
ATP1B1
Uniprot ID:
P05026
Molecular weight:
35061.1
General function:
Involved in ATP binding
Specific function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
Gene Name:
ATP12A
Uniprot ID:
P54707
Molecular weight:
116052.03
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit
Gene Name:
ATP1B4
Uniprot ID:
Q9UN42
Molecular weight:
41597.4
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A1
Uniprot ID:
P05023
Molecular weight:
112895.01
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A3
Uniprot ID:
P13637
Molecular weight:
113132.965
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
Not Available
Gene Name:
ATP4B
Uniprot ID:
P51164
Molecular weight:
33367.0
General function:
Involved in ATP binding
Specific function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
Gene Name:
ATP4A
Uniprot ID:
P20648
Molecular weight:
114117.74
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A2
Uniprot ID:
P50993
Molecular weight:
112264.385

Only showing the first 10 proteins. There are 84 proteins in total.