Showing Compound Card for Potassium (CDB005090)

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Record Information
Version1.0
Created at2020-04-17 19:08:19 UTC
Updated at2020-11-18 16:39:19 UTC
CannabisDB IDCDB005090
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NamePotassium
DescriptionPotassium, also known as K+ or potassium ion, belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. Potassium is a weakly acidic compound (based on its pKa). Potassium exists in all living species, ranging from bacteria to humans. In humans, potassium is involved in the metabolic disorder called the phenytoin (antiarrhythmic) action pathway. Outside of the human body, Potassium is found, on average, in the highest concentration within a few different foods, such as kombus, milk (cow), and garden tomato (var.) and in a lower concentration in yogurts, strawberries, and zwiebacks. Potassium has also been detected, but not quantified in, several different foods, such as sourdocks, half-highbush blueberries, wax apples, jostaberries, and medlars. This could make potassium a potential biomarker for the consumption of these foods. Potassium is a potentially toxic compound. Potassium is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
Chemical FormulaK
Average Molecular Weight39.1
Monoisotopic Molecular Weight38.9637
IUPAC Namepotassium(1+) ion
Traditional Namepotassium(1+) ion
CAS Registry Number7440-09-7
SMILES
[K+]
InChI Identifier
InChI=1S/K/q+1
InChI KeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkali metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkali metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkali metal
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point63.2 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.2ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MSNot Available
MS/MS
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Transporters
Metal Bindings
Receptors
Protein NameGene NameLocusUniprot IDDetails
Sodium/potassium-transporting ATPase subunit alpha-3ATP1A319q13.31P13637 details
Gamma-aminobutyric acid type B receptor subunit 1GABBR16p21.31Q9UBS5 details
Steroidogenic factor 1NR5A19q33Q13285 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Potassium voltage-gated channel subfamily H member 2KCNH27q36.1Q12809 details
Steroidogenic factor 1NR5A19q33Q13285 details
Potassium voltage-gated channel subfamily H member 1KCNH11q32.2O95259 details
Concentrations Data
Cannabis CultivarStatusValueReferenceDetails
Alien DawgDetected and Quantified46.935 mg/g dry wt
    • David S. Wishart,...
 details
GabriolaDetected and Quantified44.449 mg/g dry wt
    • David S. Wishart,...
 details
Island HoneyDetected and Quantified41.741 mg/g dry wt
    • David S. Wishart,...
 details
QuadraDetected and Quantified36.899 mg/g dry wt
    • David S. Wishart,...
 details
Sensi StarDetected and Quantified44.703 mg/g dry wt
    • David S. Wishart,...
 details
Tangerine DreamDetected and Quantified29.918 mg/g dry wt
    • David S. Wishart,...
 details
HMDB IDHMDB0000586
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB003521
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDC00238
BioCyc IDNot Available
BiGG ID34349
Wikipedia LinkPotassium
METLIN ID3197
PubChem Compound813
PDB IDNot Available
ChEBI ID29103
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 84 proteins in total.

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Enzymes

Enzyme Details
1. 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:
BCKDHA
Uniprot ID:
P12694
Molecular weight:
50470.58
Enzyme Details
2. S-adenosylmethionine synthase isoform type-2
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT2A
Uniprot ID:
P31153
Molecular weight:
43660.37
Enzyme Details
3. S-adenosylmethionine synthase isoform type-1
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT1A
Uniprot ID:
Q00266
Molecular weight:
43647.6
Enzyme Details
4. Pyruvate kinase isozymes M1/M2
General function:
Involved in magnesium ion binding
Specific function:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Gene Name:
PKM
Uniprot ID:
P14618
Molecular weight:
65930.14
Enzyme Details
5. Pyruvate kinase isozymes R/L
General function:
Involved in magnesium ion binding
Specific function:
Plays a key role in glycolysis (By similarity).
Gene Name:
PKLR
Uniprot ID:
P30613
Molecular weight:
61829.575
Enzyme Details
6. Inosine-5'-monophosphate dehydrogenase 2
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH2
Uniprot ID:
P12268
Molecular weight:
55804.495
Enzyme Details
7. Inosine-5'-monophosphate dehydrogenase 1
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH1
Uniprot ID:
P20839
Molecular weight:
63252.24
Enzyme Details
8. Pyridoxal kinase
General function:
Involved in pyridoxal kinase activity
Specific function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name:
PDXK
Uniprot ID:
O00764
Molecular weight:
35102.105
Enzyme Details
9. Sodium/potassium-transporting ATPase subunit beta-3
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known
Gene Name:
ATP1B3
Uniprot ID:
P54709
Molecular weight:
31512.3
Enzyme Details
10. Sodium/potassium-transporting ATPase subunit beta-2
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Gene Name:
ATP1B2
Uniprot ID:
P14415
Molecular weight:
33366.9

Transporters

Enzyme Details
1. Sodium/potassium-transporting ATPase subunit beta-3
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known
Gene Name:
ATP1B3
Uniprot ID:
P54709
Molecular weight:
31512.3
Enzyme Details
2. Sodium/potassium-transporting ATPase subunit beta-2
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Gene Name:
ATP1B2
Uniprot ID:
P14415
Molecular weight:
33366.9
Enzyme Details
3. Sodium/potassium-transporting ATPase subunit beta-1
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane
Gene Name:
ATP1B1
Uniprot ID:
P05026
Molecular weight:
35061.1
Enzyme Details
4. Potassium-transporting ATPase alpha chain 2
General function:
Involved in ATP binding
Specific function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
Gene Name:
ATP12A
Uniprot ID:
P54707
Molecular weight:
116052.03
Enzyme Details
5. Protein ATP1B4
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit
Gene Name:
ATP1B4
Uniprot ID:
Q9UN42
Molecular weight:
41597.4
Enzyme Details
6. Sodium/potassium-transporting ATPase subunit alpha-1
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A1
Uniprot ID:
P05023
Molecular weight:
112895.01
Enzyme Details
7. Sodium/potassium-transporting ATPase subunit alpha-3
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A3
Uniprot ID:
P13637
Molecular weight:
113132.965
Enzyme Details
8. Potassium-transporting ATPase subunit beta
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
Not Available
Gene Name:
ATP4B
Uniprot ID:
P51164
Molecular weight:
33367.0
Enzyme Details
9. Potassium-transporting ATPase alpha chain 1
General function:
Involved in ATP binding
Specific function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
Gene Name:
ATP4A
Uniprot ID:
P20648
Molecular weight:
114117.74
Enzyme Details
10. Sodium/potassium-transporting ATPase subunit alpha-2
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A2
Uniprot ID:
P50993
Molecular weight:
112264.385

Only showing the first 10 proteins. There are 84 proteins in total.

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