Showing Protein Potassium voltage-gated channel subfamily E member 3 (CDBP03355)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03355
Secondary Accession Numbers Not Available
Name Potassium voltage-gated channel subfamily E member 3
Description Not Available
Synonyms
  1. MinK-related peptide 2
  2. Minimum potassium ion channel-related peptide 2
  3. Potassium channel subunit beta MiRP2
Gene Name KCNE3
Protein Type Transporter
Biological Properties
General Function Involved in voltage-gated potassium channel activity
Specific Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
Process
establishment of localization
transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q13.4
SNPs KCNE3
Gene Sequence 
>312 bp
ATGGAGACTACCAATGGAACGGAGACCTGGTATGAGAGCCTGCATGCCGTGCTGAAGGCT
CTAAATGCCACTCTTCACAGCAATTTGCTCTGCCGGCCAGGGCCAGGGCTGGGGCCAGAC
AACCAGACTGAAGAGAGGCGGGCCAGCCTACCTGGCCGTGATGACAACTCCTACATGTAC
ATTCTCTTTGTCATGTTTCTATTTGCTGTAACTGTGGGCAGCCTCATCCTGGGATACACC
CGCTCCCGCAAAGTGGACAAGCGTAGTGACCCCTATCATGTGTATATCAAGAACCGTGTG
TCTATGATCTAA
Protein Properties
Number of Residues 103
Molecular Weight 11710.3
Theoretical pI 9.01
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["58-78"]
Protein Sequence 
>Potassium voltage-gated channel subfamily E member 3
METTNGTETWYESLHAVLKALNATLHSNLLCRPGPGLGPDNQTEERRASLPGRDDNSYMY
ILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
GenBank ID Protein 4704429
UniProtKB/Swiss-Prot ID Q9Y6H6
UniProtKB/Swiss-Prot Entry Name KCNE3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF076531
GeneCard ID KCNE3
GenAtlas ID KCNE3
HGNC ID HGNC:6243
References
General References Not Available