| Identification |
|---|
| HMDB Protein ID
| CDBP03356 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium voltage-gated channel subfamily H member 1 |
| Description
| Not Available |
| Synonyms
|
- EAG channel 1
- Ether-a-go-go potassium channel 1
- Voltage-gated potassium channel subunit Kv10.1
- h-eag
- hEAG1
|
| Gene Name
| KCNH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts |
| GO Classification
|
| Component |
| cell part |
| membrane |
| Function |
| potassium channel activity |
| catalytic activity |
| voltage-gated potassium channel activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| protein histidine kinase activity |
| two-component sensor activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| molecular transducer activity |
| signal transducer activity |
| protein kinase activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| Process |
| transmembrane transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| signaling process |
| ion transport |
| signal transmission |
| cation transport |
| two-component signal transduction system (phosphorelay) |
| establishment of localization |
| transport |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q32.2 |
| SNPs
| KCNH1 |
| Gene Sequence
|
>2970 bp
ATGACCATGGCTGGGGGCAGGAGGGGACTAGTGGCCCCTCAAAACACGTTTCTGGAGAAT
ATTGTTCGGCGGTCCAATGATACTAATTTTGTGTTGGGGAATGCTCAGATAGTGGACTGG
CCTATTGTGTACAGCAATGATGGATTTTGCAAGCTGTCTGGCTATCACAGGGCAGAAGTG
ATGCAAAAAAGCAGCACCTGCAGTTTTATGTATGGGGAGCTGACTGATAAAGACACGATT
GAAAAAGTGCGGCAAACATTTGAGAACTATGAGATGAATTCCTTTGAAATTCTGATGTAC
AAGAAGAACAGGACACCTGTGTGGTTCTTTGTGAAAATTGCTCCAATTCGAAACGAACAG
GATAAAGTGGTTTTATTTCTTTGCACTTTCAGTGACATAACAGCTTTCAAACAGCCAATT
GAGGATGATTCATGTAAAGGCTGGGGGAAGTTTGCTCGGCTGACAAGAGCACTGACAAGC
AGCAGGGGTGTCCTGCAGCAGCTGGCTCCAAGCGTGCAAAAAGGCGAGAATGTCCACAAG
CACTCCCGCCTGGCAGAGGTCCTACAGCTGGGCTCAGACATCCTTCCCCAGTACAAGCAA
GAGGCACCAAAGACTCCCCCTCACATCATCTTACATTATTGTGTTTTTAAGACCACGTGG
GATTGGATCATCTTGATCTTGACCTTCTATACAGCCATCTTGGTCCCTTATAATGTCTCC
TTCAAAACCAGGCAGAATAATGTGGCCTGGCTGGTTGTTGATAGCATCGTGGATGTTATC
TTTTTGGTGGACATTGTGCTCAATTTTCATACCACCTTTGTTGGACCAGCAGGGGAGGTG
ATTTCTGACCCCAAACTTATCCGCATGAACTACCTGAAGACGTGGTTTGTGATTGACCTT
CTGTCCTGTTTGCCATATGATGTCATCAACGCTTTTGAGAACGTGGATGAGGTTAGTGCC
TTTATGGGTGATCCAGGGAAGATTGGTTTTGCTGATCAGATTCCACCACCACTGGAGGGG
AGAGAGAGTCAGGGCATCAGCAGCCTGTTCAGCTCTCTAAAAGTTGTCCGGCTGCTCCGT
CTTGGGCGAGTGGCCCGTAAGCTGGACCACTACATTGAATATGGAGCTGCTGTGCTGGTC
CTGCTGGTGTGTGTGTTTGGGCTGGCTGCACACTGGATGGCCTGCATCTGGTACAGCATT
GGGGACTATGAGATCTTTGACGAGGACACCAAGACAATCCGCAACAACAGCTGGCTGTAC
CAACTAGCGATGGACATTGGCACCCCTTACCAGTTTAATGGGTCTGGCTCAGGGAAGTGG
GAAGGTGGTCCCAGCAAGAATTCTGTCTACATCTCCTCGTTGTATTTCACAATGACCAGC
CTCACCAGTGTGGGCTTTGGGAACATCGCCCCATCCACAGACATTGAGAAGATCTTTGCA
GTGGCCATCATGATGATTGGCTCACTTCTCTATGCCACCATCTTCGGGAATGTGACGACT
ATTTTCCAACAGATGTATGCCAACACCAACAGATACCATGAGATGCTCAACAGTGTTCGG
GACTTCCTGAAGCTCTACCAGGTGCCAAAAGGATTGAGTGAGCGAGTAATGGATTATATT
GTGTCCACTTGGTCCATGTCCAGAGGCATTGACACAGAGAAGGTCCTGCAGATCTGCCCC
AAGGACATGAGAGCCGACATCTGCGTGCACCTGAACCGCAAGGTGTTCAAGGAGCACCCG
GCCTTCCGGCTGGCCAGTGATGGCTGCCTCCGGGCACTGGCCATGGAGTTCCAGACGGTG
CACTGTGCCCCAGGGGACCTCATCTACCATGCAGGAGAGAGCGTTGACAGCCTCTGCTTT
GTGGTTTCTGGCTCCCTGGAGGTGATCCAAGATGATGAGGTGGTGGCCATTCTAGGAAAA
GGAGACGTGTTTGGAGATGTGTTCTGGAAGGAAGCCACCCTTGCCCAGTCCTGTGCCAAT
GTTAGGGCCTTGACCTACTGTGATCTGCATGTGATCAAGCGGGATGCCCTGCAGAAAGTG
CTGGAATTCTACACGGCCTTCTCCCATTCCTTCTCCCGGAACCTGATTCTGACGTACAAC
TTGAGGAAGAGGATTGTGTTCCGGAAGATCAGCGATGTGAAACGTGAAGAGGAAGAACGC
ATGAAACGAAAGAATGAGGCCCCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTC
TTCCAGAGATTCCGACAGCAGAAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGAC
CTGGATGACCTAGATGTGGAGAAGGGCAATGTCCTTACAGAGCATGCCTCCGCCAACCAC
AGCCTCGTGAAGGCCAGCGTGGTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTC
CAGGCAGCCTCCACCTCCGGGGTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAG
TGCCTGGGCCCCAAGGGGGGCGGGGGCGATTGTGCCAAGCGCAAAAGCTGGGCCCGCTTC
AAAGATGCTTGCGGGAAGAGTGAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAG
ACACTTCCCGAGAGGACAAAAGCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGT
GACAGTGGCATCACCAAGAGCGACTTGCGCCTGGACAACGTGGGTGAGGCCAGGAGTCCC
CAGGATCGGAGTCCCATCCTGGCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAG
ACGCTGCAGGCCACAGTCCTGGAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTA
AACGCCAAAATGACCAATATTGAGAAACAGCTCTCTGAGATACTCAGGATATTAACTTCC
AGAAGATCCTCTCAGTCTCCTCAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAA
TCAGAGAGAGACATTTTTGGAGCCAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 989 |
| Molecular Weight
| 111421.8 |
| Theoretical pI
| 7.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["221-241", "249-269", "295-315", "350-370", "377-397", "478-498"]
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily H member 1
MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV
MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ
DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK
HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS
FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL
LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR
LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY
QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA
VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI
VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV
HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN
VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER
MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH
SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF
KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP
QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS
RRSSQSPQELFEISRPQSPESERDIFGAS
|
| External Links |
|---|
| GenBank ID Protein
| 27437001 |
| UniProtKB/Swiss-Prot ID
| O95259 |
| UniProtKB/Swiss-Prot Entry Name
| KCNH1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_172362.2 |
| GeneCard ID
| KCNH1 |
| GenAtlas ID
| KCNH1 |
| HGNC ID
| HGNC:6250 |
| References |
|---|
| General References
| Not Available |