Cannabis Compound Database: Showing Protein Potassium voltage-gated channel subfamily D member 2 (CDBP04846)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04846

Secondary Accession Numbers

Not Available

Name

Potassium voltage-gated channel subfamily D member 2

Description

Not Available

Synonyms

Voltage-gated potassium channel subunit Kv4.2

Gene Name

KCND2

Protein Type

Transporter

Biological Properties

General Function

Involved in protein binding

Specific Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits

GO Classification

Component
ion channel complex
cation channel complex
potassium channel complex
voltage-gated potassium channel complex
macromolecular complex
protein complex
membrane
cell part
Function
binding
protein binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
Process
establishment of localization
transport
transmembrane transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport

Cellular Location

Cell membrane
Multi-pass membrane protein
Cell projection
dendrite

Pathways

Name	SMPDB/Pathwhiz	KEGG
Benzocaine Action Pathway		Not Available
Bupivacaine Action Pathway		Not Available
Chloroprocaine Action Pathway		Not Available
Cocaine Action Pathway		Not Available
Dibucaine Action Pathway		Not Available

Gene Properties

Chromosome Location

Chromosome:7

Locus

7q31

SNPs

KCND2

Gene Sequence

>1893 bp
ATGGCGGCGGGGGTGGCAGCGTGGCTGCCTTTTGCAAGGGCAGCGGCTATCGGGTGGATG
CCTGTGGCCTCGGGGCCTATGCCGGCTCCCCCGAGGCAGGAGAGGAAAAGGACCCAAGAT
GCTCTCATTGTGCTGAATGTGAGTGGCACCCGCTTCCAGACGTGGCAGGACACCCTGGAA
CGTTACCCAGACACTCTACTGGGCAGTTCTGAGAGGGACTTTTTCTACCACCCAGAAACT
CAGCAGTATTTCTTTGACCGTGACCCAGACATCTTCCGCCACATCCTGAATTTCTACCGC
ACTGGGAAGCTCCACTATCCTCGCCACGAGTGCATCTCTGCTTACGATGAAGAACTGGCC
TTCTTTGGCCTCATCCCGGAAATCATCGGCGACTGCTGTTATGAGGAGTACAAGGATCGC
AGGCGAGAGAACGCCGAGCGCCTGCAGGACGACGCGGATACCGACACCGCTGGGGAGAGC
GCCTTGCCCACCATGACTGCAAGGCAGAGGGTCTGGAGGGCCTTCGAGAACCCCCACACC
AGCACGATGGCCCTGGTGTTCTACTATGTCACGGGGTTTTTCATTGCCGTCTCTGTCATC
GCGAATGTGGTGGAAACAGTGCCGTGCGGATCAAGCCCAGGTCACATTAAAGAACTGCCC
TGTGGAGAGCGGTATGCTGTGGCCTTCTTCTGCTTGGACACGGCCTGCGTCATGATCTTC
ACAGTTGAGTATTTGCTTCGCCTGGCTGCAGCGCCTAGTCGTTACCGTTTTGTGCGTAGT
GTCATGAGTATCATCGACGTGGTGGCCATCCTGCCTTATTACATTGGGCTGGTGATGACA
GACAATGAGGACGTCAGCGGAGCCTTTGTCACACTCCGAGTCTTCCGGGTCTTCAGGATC
TTTAAGTTTTCCCGCCACTCTCAAGGCCTGCGCATCCTGGGGTACACACTGAAGAGTTGT
GCCTCAGAATTGGGCTTCTTGCTTTTCTCGCTCACCATGGCTATCATCATTTTCGCTACG
GTTATGTTCTACGCAGAGAAGGGCTCTTCAGCAAGCAAGTTCACCAGCATCCCTGCAGCC
TTCTGGTACACCATCGTCACCATGACAACACTGGGGTATGGCGACATGGTACCAAAAACC
ATAGCAGGGAAGATTTTCGGGTCTATCTGCTCACTGAGCGGAGTCTTGGTCATCGCGCTA
CCCGTGCCTGTGATCGTGTCTAACTTCAGTCGGATCTACCACCAAAACCAACGAGCGGAC
AAACGAAGGGCACAGAAGAAAGCGAGGCTGGCCAGGATCCGGGCAGCCAAAAGTGGAAGT
GCAAATGCCTACATGCAGAGCAAGCGGAGTGGGTTACTGAGCAACCAACTGCAGTCCTCG
GAGGATGAACCGGCCTTCGTTAGCAAATCTGGATCCAGCTTCGAGACGCAACACCACCAC
CTGCTTCACTGCCTGGAGAAAACCACGAACCATGAGTTTGTGGATGAACAAGTCTTTGAA
GAAAGCTGCATGGAAGTGGCCACTGTTAATCGCCCTTCAAGTCACAGCCCCTCCCTCTCT
TCCCAACAAGGAGTCACCAGCACTTGCTGCTCACGGAGACACAAAAAAACTTTCCGAATC
CCAAATGCCAATGTGTCAGGAAGTCATAGAGGCAGCGTGCAAGAACTCAGTACAATTCAG
ATCAGATGTGTGGAGAGAACTCCACTATCCAACAGCCGATCCAGCTTAAATGCCAAAATG
GAAGAGTGTGTCAAACTAAACTGTGAACAACCTTACGTGACCACAGCAATAATTAGCATT
CCAACACCTCCAGTAACCACCCCAGAAGGCGACGACAGGCCCGAGTCTCCTGAGTATTCG
GGAGGAAACATCGTCAGGGTGTCTGCTTTGTAA

Protein Properties

Number of Residues

630

Molecular Weight

70535.8

Theoretical pI

8.03

Pfam Domain Function

Ion_trans (PF00520 )
K_tetra (PF02214 )
Shal-type (PF11601 )

Signals

["None"]

Transmembrane Regions

["184-204", "225-245", "260-280", "290-310", "324-344", "385-405"]

Protein Sequence

>Potassium voltage-gated channel subfamily D member 2
MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE
RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA
FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHT
STMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIF
TVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRI
FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAA
FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD
KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHH
LLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRI
PNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISI
PTPPVTTPEGDDRPESPEYSGGNIVRVSAL

External Links

GenBank ID Protein

4530478

UniProtKB/Swiss-Prot ID

Q9NZV8

UniProtKB/Swiss-Prot Entry Name

KCND2_HUMAN

PDB IDs