| Identification |
|---|
| HMDB Protein ID
| CDBP02970 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcium-activated potassium channel subunit beta-3 |
| Description
| Not Available |
| Synonyms
|
- BK channel subunit beta-3
- BKbeta3
- Calcium-activated potassium channel, subfamily M subunit beta-3
- Charybdotoxin receptor subunit beta-3
- Hbeta3
- K(VCA)beta-3
- Maxi K channel subunit beta-3
- Slo-beta-3
|
| Gene Name
| KCNMB3 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in calcium-activated potassium channel activity |
| Specific Function
| Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| calcium activated cation channel activity |
| calcium-activated potassium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| Process |
| ion transport |
| cation transport |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| potassium ion transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q26.3-q27 |
| SNPs
| KCNMB3 |
| Gene Sequence
|
>840 bp
ATGGACTTTTCACCAAGCTCTGAACTGGGATTTCATTTTGTTGCATTCATCCTGCTCACG
AGACACAGGACAGCCTTTCCTGCCTCAGGGAAGAAGAGAGAGACAGACTACAGTGATGGA
GACCCACTAGATGTGCACAAGAGGCTGCCATCCAGTGCTGGAGAGGACCGAGCCGTGATG
CTGGGGTTTGCCATGATGGGCTTCTCAGTCCTAATGTTCTTCTTGCTCGGAACAACCATT
CTAAAGCCTTTTATGCTCAGCATTCAGAGAGAAGAATCGACCTGCACTGCCATCCACACA
GATATCATGGACGACTGGCTGGACTGTGCCTTCACCTGTGGTGTGCACTGCCACGGTCAG
GGGAAGTACCCGTGTCTTCAGGTGTTTGTGAACCTCAGCCATCCAGGTCAGAAAGCTCTC
CTACATTATAATGAAGAGGCTGTCCAGATAAATCCCAAGTGCTTTTACACACCTAAGTGC
CACCAAGATAGAAATGATTTGCTCAACAGTGCTCTGGACATAAAAGAATTCTTCGATCAC
AAAAATGGAACCCCCTTTTCATGCTTCTACAGTCCAGCCAGCCAATCTGAAGATGTCATT
CTTATAAAAAAGTATGACCAAATGGCTATCTTCCACTGTTTATTTTGGCCTTCACTGACT
CTGCTAGGTGGTGCCCTGATTGTTGGCATGGTGAGATTAACACAACACCTGTCCTTACTG
TGTGAAAAATATAGCACTGTAGTCAGAGATGAGGTAGGTGGAAAAGTACCTTATATAGAA
CAGCATCAGTTCAAACTGTGCATTATGAGGAGGAGCAAAGGAAGAGCAGAGAAATCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 279 |
| Molecular Weight
| 31603.3 |
| Theoretical pI
| 7.31 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcium-activated potassium channel subunit beta-3
MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVM
LGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQ
GKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDH
KNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLL
CEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS
|
| External Links |
|---|
| GenBank ID Protein
| 25952095 |
| UniProtKB/Swiss-Prot ID
| Q9NPA1 |
| UniProtKB/Swiss-Prot Entry Name
| KCMB3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014407.3 |
| GeneCard ID
| KCNMB3 |
| GenAtlas ID
| KCNMB3 |
| HGNC ID
| HGNC:6287 |
| References |
|---|
| General References
| Not Available |