| Identification |
|---|
| HMDB Protein ID
| CDBP02965 |
| Secondary Accession Numbers
| Not Available |
| Name
| Kv channel-interacting protein 1 |
| Description
| Not Available |
| Synonyms
|
- A-type potassium channel modulatory protein 1
- KChIP1
- Potassium channel-interacting protein 1
- Vesicle APC-binding protein
|
| Gene Name
| KCNIP1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface |
| GO Classification
|
| Function |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| cation binding |
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q35.1 |
| SNPs
| KCNIP1 |
| Gene Sequence
|
>684 bp
ATGGGGGCCGTCATGGGCACCTTCTCATCTCTGCAAACCAAACAAAGGCGACCCTCGAAA
GACATCGCCTGGTGGTATTACCAGTATCAGAGAGATAAGATTGAAGATGAGCTGGAGATG
ACCATGGTTTGCCATCGGCCCGAGGGACTGGAGCAGCTCGAGGCCCAGACCAACTTCACC
AAGAGGGAGCTGCAGGTCCTTTATCGAGGCTTCAAAAATGAGTGCCCCAGTGGTGTGGTC
AACGAAGACACATTCAAGCAGATCTATGCTCAGTTTTTCCCTCATGGAGATGCCAGCACG
TATGCCCATTACCTCTTCAATGCCTTCGACACCACTCAGACAGGCTCCGTGAAGTTCGAG
GACTTTGTAACCGCTCTGTCGATTTTATTGAGAGGAACTGTCCACGAGAAACTAAGGTGG
ACATTTAATTTGTATGACATCAACAAGGACGGATACATAAACAAAGAGGAGATGATGGAC
ATTGTCAAAGCCATCTATGACATGATGGGGAAATACACATATCCTGTGCTCAAAGAGGAC
ACTCCAAGGCAGCATGTGGACGTCTTCTTCCAGAAAATGGACAAAAATAAAGATGGCATC
GTAACTTTAGATGAATTTCTTGAATCATGTCAGGAGGACGACAACATCATGAGGTCTCTC
CAGCTGTTTCAAAATGTCATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 227 |
| Molecular Weight
| 26817.3 |
| Theoretical pI
| 4.89 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Kv channel-interacting protein 1
MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQRDKIEDELEMTMVCHRPEGLEQLEAQTNFT
KRELQVLYRGFKNECPSGVVNEDTFKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFE
DFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKED
TPRQHVDVFFQKMDKNKDGIVTLDEFLESCQEDDNIMRSLQLFQNVM
|
| External Links |
|---|
| GenBank ID Protein
| 78190480 |
| UniProtKB/Swiss-Prot ID
| Q9NZI2 |
| UniProtKB/Swiss-Prot Entry Name
| KCIP1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001034837.1 |
| GeneCard ID
| KCNIP1 |
| GenAtlas ID
| KCNIP1 |
| HGNC ID
| HGNC:15521 |
| References |
|---|
| General References
| Not Available |