| Identification |
|---|
| HMDB Protein ID
| CDBP04841 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium voltage-gated channel subfamily E member 1 |
| Description
| Not Available |
| Synonyms
|
- Delayed rectifier potassium channel subunit IsK
- IKs producing slow voltage-gated potassium channel subunit beta Mink
- Minimal potassium channel
|
| Gene Name
| KCNE1 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated potassium channel activity |
| Specific Function
| Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| potassium channel activity |
| voltage-gated potassium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Muscle/Heart Contraction |    | Not Available | | Acebutolol Action Pathway |    | Not Available | | Alprenolol Action Pathway |    | Not Available | | Atenolol Action Pathway |    | Not Available | | Betaxolol Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 21q22.1-q22.2|21q22.12 |
| SNPs
| KCNE1 |
| Gene Sequence
|
>390 bp
ATGATCCTGTCTAACACCACAGCGGTGACGCCCTTTCTGACCAAGCTGTGGCAGGAGACA
GTTCAGCAGGGTGGCAACATGTCGGGCCTGGCCCGCAGGTCCCCCCGCAGCAGTGACGGC
AAGCTGGAGGCCCTCTACGTCCTCATGGTACTGGGATTCTTCGGCTTCTTCACCCTGGGC
ATCATGCTGAGCTACATCCGCTCCAAGAAGCTGGAGCACTCGAACGACCCATTCAACGTC
TACATCGAGTCCGATGCCTGGCAAGAGAAGGACAAGGCCTATGTCCAGGCCCGGGTCCTG
GAGAGCTACAGGTCGTGCTATGTCGTTGAAAACCATCTGGCCATAGAACAACCCAACACA
CACCTTCCTGAGACGAAGCCTTCCCCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 129 |
| Molecular Weight
| 14674.7 |
| Theoretical pI
| 7.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Potassium voltage-gated channel subfamily E member 1
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
|
| External Links |
|---|
| GenBank ID Protein
| 4583499 |
| UniProtKB/Swiss-Prot ID
| P15382 |
| UniProtKB/Swiss-Prot Entry Name
| KCNE1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF135188 |
| GeneCard ID
| KCNE1 |
| GenAtlas ID
| KCNE1 |
| HGNC ID
| HGNC:6240 |
| References |
|---|
| General References
| Not Available |