Showing Protein Potassium voltage-gated channel subfamily A member 3 (CDBP04850)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04850
Secondary Accession Numbers Not Available
Name Potassium voltage-gated channel subfamily A member 3
Description Not Available
Synonyms
  1. HGK5
  2. HLK3
  3. HPCN3
  4. Voltage-gated K(+) channel HuKIII
  5. Voltage-gated potassium channel subunit Kv1.3
Gene Name KCNA3
Protein Type Transporter
Biological Properties
General Function Involved in protein binding
Specific Function Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient
GO Classification
Component
cation channel complex
potassium channel complex
voltage-gated potassium channel complex
macromolecular complex
protein complex
membrane
cell part
ion channel complex
Function
binding
protein binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
Process
transport
transmembrane transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
establishment of localization
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p13.3
SNPs KCNA3
Gene Sequence 
>1728 bp
ATGGACGAGCGCCTCAGCCTTCTGCGCTCGCCGCCGCCGCCCTCAGCCCGCCACCGCGCC
CACCCTCCTCAGCGCCCAGCGAGCAGCGGCGGTGCCCACACGCTGGTGAACCACGGCTAC
GCGGAGCCCGCCGCAGGCCGCGAGCTGCCGCCCGACATGACCGTGGTGCCCGGGGACCAC
CTGCTGGAGCCGGAGGTGGCCGATGGTGGAGGGGCCCCGCCTCAAGGCGGCTGTGGCGGC
GGCGGCTGCGACCGCTACGAGCCGCTGCCGCCCTCACTGCCGGCCGCGGGCGAGCAGGAC
TGCTGCGGGGAGCGCGTGGTCATCAACATCTCCGGGCTGCGCTTCGAGACGCAGCTGAAG
ACCCTTTGCCAGTTCCCCGAGACGCTGCTGGGCGACCCCAAGCGGCGCATGAGGTACTTC
GACCCGCTCCGCAACGAGTACTTCTTCGACCGCAACCGGCCCAGCTTCGACGCCATCCTC
TACTACTATCAGTCCGGGGGCCGCATCCGCCGGCCGGTCAACGTGCCCATCGACATTTTC
TCCGAGGAGATCCGCTTCTACCAGCTGGGCGAGGAGGCCATGGAGAAGTTCCGCGAGGAC
GAGGGCTTCCTGCGGGAGGAGGAGCGGCCCTTGCCCCGCCGCGACTTCCAGCGCCAGGTG
TGGCTGCTCTTCGAGTACCCCGAGAGCTCCGGGCCGGCCCGGGGCATCGCCATCGTGTCC
GTGCTGGTCATCCTCATCTCCATTGTCATCTTCTGCCTGGAGACGCTGCCGGAGTTCCGC
GACGAGAAGGACTACCCCGCCTCGACGTCGCAGGACTCATTCGAAGCAGCCGGCAACAGC
ACGTCGGGGTCCCGCGCAGGAGCCTCCAGCTTCTCCGATCCCTTCTTCGTGGTGGAGACG
CTGTGCATCATCTGGTTCTCCTTCGAACTGCTGGTGCGGTTCTTCGCTTGTCCTAGCAAA
GCCACCTTCTCGCGAAACATCATGAACCTGATCGACATTGTGGCCATCATTCCTTATTTT
ATCACTCTGGGTACCGAGCTGGCCGAACGACAGGGCAATGGACAGCAGGCCATGTCTCTG
GCCATCCTGAGGGTCATCCGCCTGGTAAGGGTCTTCCGCATCTTCAAGCTGTCGCGCCAC
TCCAAGGGGCTGCAGATCCTCGGGCAAACGCTGAAGGCGTCCATGCGGGAGCTGGGATTG
CTCATCTTCTTCCTCTTTATTGGGGTCATCCTTTTCTCCAGCGCGGTCTACTTTGCCGAG
GCAGACGACCCCACTTCAGGTTTCAGCAGCATCCCGGATGCCTTCTGGTGGGCAGTGGTA
ACCATGACAACAGTGGGTTACGGCGATATGCACCCAGTGACCATAGGGGGCAAGATTGTG
GGATCTCTCTGTGCCATCGCCGGTGTCTTGACCATCGCATTGCCAGTTCCCGTGATTGTT
TCCAACTTCAATTACTTCTACCACCGGGAGACAGAAGGGGAAGAGCAATCCCAGTACATG
CACGTGGGAAGTTGCCAGCACCTCTCCTCTTCAGCCGAGGAGCTCCGAAAAGCAAGGAGT
AACTCGACTCTGAGTAAGTCGGAGTATATGGTGATCGAAGAGGGGGGTATGAACCATAGC
GCTTTCCCCCAGACCCCTTTCAAAACGGGCAATTCCACTGCCACCTGCACCACGAACAAT
AATCCCAACTCTTGTGTCAACATCAAAAAGATATTCACCGATGTTTAA
Protein Properties
Number of Residues 575
Molecular Weight 63841.1
Theoretical pI 5.68
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["235-253", "295-316", "328-348", "363-381", "398-417", "459-481"]
Protein Sequence 
>Potassium voltage-gated channel subfamily A member 3
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDH
LLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLK
TLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIF
SEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVET
LCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSL
AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE
ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV
SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHS
AFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
GenBank ID Protein 55664008
UniProtKB/Swiss-Prot ID P22001
UniProtKB/Swiss-Prot Entry Name KCNA3_HUMAN
PDB IDs
GenBank Gene ID AL365361
GeneCard ID KCNA3
GenAtlas ID KCNA3
HGNC ID HGNC:6221
References
General References Not Available