Cannabis Compound Database: Showing Compound Card for DG(18:0/16:0/0:0) (CDB000876)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (92)transporters (3) Show 148 proteins XML

Record Information

Version

1.0

Created at

2020-03-30 17:48:45 UTC

Updated at

2020-12-07 19:07:49 UTC

CannabisDB ID

CDB000876

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

DG(18:0/16:0/0:0)

Description

DG(18:0/16:0/0:0) belongs to the family of Diacylglycerols. These are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. DG(18:0/16:0/0:0) is also a substrate of diacylglycerol kinase. It is involved in the phospholipid metabolic pathway. This compound is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
1-Stearoyl-2-palmitoyl-sn-glycerol	HMDB
DAG(18:0/16:0)	HMDB
DAG(34:0)	HMDB
DG(18:0/16:0)	HMDB
DG(34:0)	HMDB
Diacylglycerol	HMDB
Diacylglycerol(18:0/16:0)	HMDB
Diacylglycerol(34:0)	HMDB
Diglyceride	HMDB
1-Octadecanoyl-2-hexadecanoyl-sn-glycerol	HMDB
DG(18:0/16:0/0:0)	Lipid Annotator

Chemical Formula

C₃₇H₇₂O₅

Average Molecular Weight

596.96

Monoisotopic Molecular Weight

596.538

IUPAC Name

(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl octadecanoate

Traditional Name

diacylglycerol

CAS Registry Number

Not Available

SMILES

[H][C@](CO)(COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC

InChI Identifier

InChI=1S/C37H72O5/c1-3-5-7-9-11-13-15-17-18-20-21-23-25-27-29-31-36(39)41-34-35(33-38)42-37(40)32-30-28-26-24-22-19-16-14-12-10-8-6-4-2/h35,38H,3-34H2,1-2H3/t35-/m0/s1

InChI Key

VYQDALBEQRZDPL-DHUJRADRSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 1,2-diacylglycerols. These are diacylglycerols containing a glycerol acylated at positions 1 and 2.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerolipids

Sub Class

Diradylglycerols

Direct Parent

1,2-diacylglycerols

Alternative Parents

Substituents

1,2-acyl-sn-glycerol
Fatty acid ester
Fatty acyl
Dicarboxylic acid or derivatives
Carboxylic acid ester
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Diacylglycerols (LMGL02010003 )

Ontology

Ingestion

Source:

Biological:

Animal

Biological location:

Tissue and substructures:

All tissues

Biofluid and excreta:

Blood

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	10.16	ALOGPS
logP	12.89	ChemAxon
logS	-7.5	ALOGPS
pKa (Strongest Acidic)	14.58	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	72.83 Å²	ChemAxon
Rotatable Bond Count	36	ChemAxon
Refractivity	176.9 m³·mol⁻¹	ChemAxon
Polarizability	78.94 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	DG(18:0/16:0/0:0), 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0fe0-7193676000-02176a51035bb5071de8	Spectrum
Predicted GC-MS	DG(18:0/16:0/0:0), TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	DG(18:0/16:0/0:0), "DG(18:0/16:0/0:0),1TMS,#1" TMS, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-0000009000-225e45a97a85093b82dc	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03fu-0009030000-ca569c37810c32ea767b	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03dl-0009013000-d6dc916220d606c45bdc	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available	2020-06-30	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available	2020-06-30	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available	2020-06-30	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-0000009000-05c8a9d62d254739db0a	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-014i-0000009000-05c8a9d62d254739db0a	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03e0-0009000000-59c3f0e0ceb618daf530	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0532-1093050000-7dfc139d8608a34c6d50	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-2091000000-d472762cc1703145d1af	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-05o0-1190000000-7876d5937960785e4991	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-01pa-1296060000-0e777cab8c1fd7de08f8	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-3493010000-8cd23e9c43e7b4d3beeb	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0553-9462000000-3b9cc0015f1b06e67534	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-0000009000-af6a422dabc6060234c0	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03fu-0009030000-f6f8dca55460cbe46e3d	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03dl-0009013000-241963e6ecb36ed141c6	2021-09-22	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
De Novo Triacylglycerol Biosynthesis TG(18:0/16:0/18:1(11Z))		Not Available
De Novo Triacylglycerol Biosynthesis TG(18:0/16:0/18:3(9Z,12Z,15Z))		Not Available
De Novo Triacylglycerol Biosynthesis TG(18:0/16:0/18:0)		Not Available
De Novo Triacylglycerol Biosynthesis TG(18:0/16:0/20:0)		Not Available
De Novo Triacylglycerol Biosynthesis TG(18:0/16:0/22:0)		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Diacylglycerol kinase theta	DGKQ	4p16.3	P52824	details
Pancreatic triacylglycerol lipase	PNLIP	10q26.1	P16233	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	PLCB1	20p12	Q9NQ66	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	PLCB4	20p12	Q15147	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	PLCB2	15q15	Q00722	details
Diacylglycerol kinase gamma	DGKG	3q27.2-q27.3	P49619	details
Hepatic triacylglycerol lipase	LIPC	15q21-q23	P11150	details
Lysosomal acid lipase/cholesteryl ester hydrolase	LIPA	10q23.2-q23.3	P38571	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	PLCB3	11q13	Q01970	details
Inactive pancreatic lipase-related protein 1	PNLIPRP1		P54315	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	PLCG2	16q24.1	P16885	details
Lipid phosphate phosphohydrolase 2	PPAP2C	19p13	O43688	details
Patatin-like phospholipase domain-containing protein 3	PNPLA3	22q13.31	Q9NST1	details
Diacylglycerol kinase alpha	DGKA	12q13.3	P23743	details
Diacylglycerol kinase delta	DGKD	2q37.1	Q16760	details
Diacylglycerol kinase epsilon	DGKE	17q22	P52429	details
Gastric triacylglycerol lipase	LIPF	10q23.31	P07098	details
Lipid phosphate phosphohydrolase 1	PPAP2A	5q11	O14494	details
Diacylglycerol kinase beta	DGKB	7p21.2	Q9Y6T7	details
Endothelial lipase	LIPG	18q21.1	Q9Y5X9	details
Diacylglycerol kinase iota	DGKI	7q32.3-q33	O75912	details
Bile salt-activated lipase	CEL	9q34.3	P19835	details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details
Diacylglycerol O-acyltransferase 1	DGAT1	8q24.3	O75907	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLCG1	20q12-q13.1	P19174	details
Pancreatic lipase-related protein 2	PNLIPRP2	10q25.3	P54317	details
Diacylglycerol kinase zeta	DGKZ	11p11.2	Q13574	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	PLCD1	3p22-p21.3	P51178	details
Lipoprotein lipase	LPL	8p22	P06858	details
Galactosylceramide sulfotransferase	GAL3ST1	22q12.2	Q99999	details
Hormone-sensitive lipase	LIPE	19q13.2	Q05469	details
Phosphatidate cytidylyltransferase 2	CDS2	20p13	O95674	details
Choline-phosphate cytidylyltransferase A	PCYT1A	3q29	P49585	details
Phosphatidate cytidylyltransferase 1	CDS1	4q21.23	Q92903	details
Phosphatidylcholine:ceramide cholinephosphotransferase 2	SGMS2	4q25	Q8NHU3	details
CDP-diacylglycerol--inositol 3-phosphatidyltransferase	CDIPT	16p11.2	O14735	details
Phosphatidylcholine:ceramide cholinephosphotransferase 1	SGMS1	10q11.2	Q86VZ5	details
RAF proto-oncogene serine/threonine-protein kinase	RAF1	3p25	P04049	details
Protein kinase C alpha type	PRKCA	17q22-q23.2	P17252	details
Serine/threonine-protein kinase A-Raf	ARAF		P10398	details
Citron Rho-interacting kinase	CIT	12q24	O14578	details
Protein kinase C beta type	PRKCB	16p11.2	P05771	details
Protein kinase C zeta type	PRKCZ	1p36.33-p36.2	Q05513	details
Protein kinase C iota type	PRKCI	3q26.3	P41743	details
Rho-associated protein kinase 1	ROCK1	18q11.1	Q13464	details
Serine/threonine-protein kinase D1	PRKD1	14q11	Q15139	details
Protein kinase C gamma type	PRKCG	19q13.4	P05129	details
Rho-associated protein kinase 2	ROCK2	2p24	O75116	details
Protein kinase C delta type	PRKCD	3p21.31	Q05655	details
Serine/threonine-protein kinase D3	PRKD3	2p21	O94806	details
Protein kinase C theta type	PRKCQ	10p15	Q04759	details
Protein kinase C eta type	PRKCH	14q23.1	P24723	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	PLCH2	1p36.32	O75038	details
Protein kinase C epsilon type	PRKCE	2p21	Q02156	details
Serine/threonine-protein kinase B-raf	BRAF	7q34	P15056	details
Cholinephosphotransferase 1	CHPT1	12q	Q8WUD6	details
2-acylglycerol O-acyltransferase 2	MOGAT2	11q13.5	Q3SYC2	details
Patatin-like phospholipase domain-containing protein 4	PNPLA4	Xp22.3	P41247	details
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial	PGS1	17q25.3	Q32NB8	details
Diacylglycerol kinase eta	DGKH	13q14.11	Q86XP1	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	PLCD4	2q35	Q9BRC7	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	PLCH1	3q25.31	Q4KWH8	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	PLCE1	10q23	Q9P212	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
Diacylglycerol O-acyltransferase 2	DGAT2	11q13.5	Q96PD7	details
2-acylglycerol O-acyltransferase 1	MOGAT1	2q36.1	Q96PD6	details
Acyl-CoA wax alcohol acyltransferase 1	AWAT1	Xq13.1	Q58HT5	details
Acyl-CoA wax alcohol acyltransferase 2	AWAT2	Xq13.1	Q6E213	details
Diacylglycerol O-acyltransferase 2-like protein 6	DGAT2L6		Q6ZPD8	details
Putative diacylglycerol O-acyltransferase 2-like protein 7	DGAT2L7	7q22.1	Q6IED9	details
Sn1-specific diacylglycerol lipase alpha	DAGLA	11q12.2	Q9Y4D2	details
Sn1-specific diacylglycerol lipase beta	DAGLB	7p22.1	Q8NCG7	details
2-acylglycerol O-acyltransferase 3	MOGAT3	7q22.1	Q86VF5	details
Diacylglycerol kinase kappa	DGKK		Q5KSL6	details
Serine/threonine-protein kinase D2	PRKD2	19q13.3	Q9BZL6	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	PLCZ1	12p12.3	Q86YW0	details
Patatin-like phospholipase domain-containing protein 2	PNPLA2	11p15.5	Q96AD5	details
A-kinase anchor protein 13	AKAP13	15q24-q25	Q12802	details
Serine/threonine-protein kinase MRCK alpha	CDC42BPA	1q42.11	Q5VT25	details
Serine/threonine-protein kinase MRCK beta	CDC42BPB	14q32.3	Q9Y5S2	details
Serine/threonine-protein kinase MRCK gamma	CDC42BPG	11q13.1	Q6DT37	details
Acylglycerol kinase, mitochondrial	AGK	7q34	Q53H12	details
Pancreatic lipase-related protein 3	PNLIPRP3	10q25.3	Q17RR3	details
CDC42 binding protein kinase beta (DMPK-like)	CDC42BPB	14q32.3	A9JR72	details
Kinase suppressor of Ras 2	KSR2	12q24.22-q24.23	Q6VAB6	details
Tensin-like C1 domain-containing phosphatase	TENC1	12q13.13	Q63HR2	details
Protein kinase C, alpha variant			Q59FI5	details
Kinase suppressor of Ras 1	KSR1	17q11.1-q11.2	Q8IVT5	details
Protein kinase C, gamma variant			Q59EZ0	details
CDC42-binding protein kinase beta	CDC42BPA	1q42.11	Q8IWQ7	details
Rho GTPase-activating protein 29	ARHGAP29	1p22.1	Q52LW3	details
Rac GTPase-activating protein 1	RACGAP1	12q13.12	Q9H0H5	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Short transient receptor potential channel 3	TRPC3	4q27	Q13507	details
Short transient receptor potential channel 6	TRPC6	11q22.1	Q9Y210	details
Short transient receptor potential channel 7	TRPC7	5q31.1	Q9HCX4	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Pancreatic triacylglycerol lipase	PNLIP	10q26.1	P16233	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	PLCB1	20p12	Q9NQ66	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	PLCB4	20p12	Q15147	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	PLCB2	15q15	Q00722	details
Diacylglycerol kinase gamma	DGKG	3q27.2-q27.3	P49619	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	PLCB3	11q13	Q01970	details
Diacylglycerol kinase alpha	DGKA	12q13.3	P23743	details
Diacylglycerol kinase beta	DGKB	7p21.2	Q9Y6T7	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	PLCD1	3p22-p21.3	P51178	details
Protein kinase C alpha type	PRKCA	17q22-q23.2	P17252	details
Protein kinase C beta type	PRKCB	16p11.2	P05771	details
Protein kinase C zeta type	PRKCZ	1p36.33-p36.2	Q05513	details
Protein kinase C iota type	PRKCI	3q26.3	P41743	details
Protein kinase C gamma type	PRKCG	19q13.4	P05129	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	PLCH2	1p36.32	O75038	details
Cholinephosphotransferase 1	CHPT1	12q	Q8WUD6	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4	PLCD4	2q35	Q9BRC7	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	PLCH1	3q25.31	Q4KWH8	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	PLCE1	10q23	Q9P212	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
Membrane-associated phosphatidylinositol transfer protein 1	PITPNM1	11q13	O00562	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	PLCZ1	12p12.3	Q86YW0	details
RAS guanyl-releasing protein 1	RASGRP1	15q14	O95267	details
RAS guanyl-releasing protein 2	RASGRP2	11q13	Q7LDG7	details
Differentially expressed in FDCP 8 homolog	DEF8	16q24.3	Q6ZN54	details
Aging-associated gene 6 protein			Q2TSD3	details
Ras guanyl-releasing protein 3	RASGRP3	2p25.1-p24.1	Q8IV61	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Diacylglycerol kinase theta	DGKQ	4p16.3	P52824	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	PLCB1	20p12	Q9NQ66	details
Diacylglycerol kinase gamma	DGKG	3q27.2-q27.3	P49619	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	PLCB3	11q13	Q01970	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	PLCG2	16q24.1	P16885	details
Diacylglycerol kinase alpha	DGKA	12q13.3	P23743	details
Diacylglycerol kinase delta	DGKD	2q37.1	Q16760	details
Diacylglycerol kinase epsilon	DGKE	17q22	P52429	details
Lipid phosphate phosphohydrolase 1	PPAP2A	5q11	O14494	details
Diacylglycerol kinase beta	DGKB	7p21.2	Q9Y6T7	details
Diacylglycerol kinase iota	DGKI	7q32.3-q33	O75912	details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLCG1	20q12-q13.1	P19174	details
Diacylglycerol kinase zeta	DGKZ	11p11.2	Q13574	details
RAF proto-oncogene serine/threonine-protein kinase	RAF1	3p25	P04049	details
Serine/threonine-protein kinase A-Raf	ARAF		P10398	details
Serine/threonine-protein kinase B-raf	BRAF	7q34	P15056	details
Short transient receptor potential channel 3	TRPC3	4q27	Q13507	details
Diacylglycerol kinase eta	DGKH	13q14.11	Q86XP1	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	PLCE1	10q23	Q9P212	details
Diacylglycerol kinase kappa	DGKK		Q5KSL6	details
Short transient receptor potential channel 6	TRPC6	11q22.1	Q9Y210	details
Short transient receptor potential channel 7	TRPC7	5q31.1	Q9HCX4	details
Acylglycerol kinase, mitochondrial	AGK	7q34	Q53H12	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	PLCB1	20p12	Q9NQ66	details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0007156

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB024350

KNApSAcK ID

Not Available

Chemspider ID

2497483

KEGG Compound ID

C00165

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

4257

PubChem Compound

3246945

PDB ID

Not Available

ChEBI ID

88529

References

General References

Not Available

Only showing the first 10 proteins. There are 148 proteins in total.

Show All

Enzymes

Enzyme Details

1. Diacylglycerol kinase theta

General function:: Involved in diacylglycerol kinase activity
Specific function:: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity
Gene Name:: DGKQ
Uniprot ID:: P52824
Molecular weight:: 101154.0

Enzyme Details

2. Pancreatic triacylglycerol lipase

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: PNLIP
Uniprot ID:: P16233
Molecular weight:: 51156.48

Enzyme Details

3. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

General function:: Involved in calcium ion binding
Specific function:: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene Name:: PLCB1
Uniprot ID:: Q9NQ66
Molecular weight:: 138565.805

Enzyme Details

4. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

General function:: Involved in calcium ion binding
Specific function:: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
Gene Name:: PLCB4
Uniprot ID:: Q15147
Molecular weight:: 136105.065

Enzyme Details

5. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

General function:: Involved in calcium ion binding
Specific function:: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene Name:: PLCB2
Uniprot ID:: Q00722
Molecular weight:: 134023.21

Enzyme Details

6. Diacylglycerol kinase gamma

General function:: Involved in diacylglycerol kinase activity
Specific function:: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid
Gene Name:: DGKG
Uniprot ID:: P49619
Molecular weight:: 89095.3

Enzyme Details

7. Hepatic triacylglycerol lipase

General function:: Involved in catalytic activity
Specific function:: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.
Gene Name:: LIPC
Uniprot ID:: P11150
Molecular weight:: 55914.1

Enzyme Details

8. Lysosomal acid lipase/cholesteryl ester hydrolase

General function:: Involved in lipid metabolic process
Specific function:: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Gene Name:: LIPA
Uniprot ID:: P38571
Molecular weight:: 45418.71

Enzyme Details

9. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

General function:: Involved in calcium ion binding
Specific function:: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Gene Name:: PLCB3
Uniprot ID:: Q01970
Molecular weight:: 138797.725

Enzyme Details

10. Inactive pancreatic lipase-related protein 1

General function:: Involved in catalytic activity
Specific function:: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).
Gene Name:: PNLIPRP1
Uniprot ID:: P54315
Molecular weight:: Not Available

Transporters

Enzyme Details

1. Short transient receptor potential channel 3

General function:: Involved in ion channel activity
Specific function:: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion
Gene Name:: TRPC3
Uniprot ID:: Q13507
Molecular weight:: 97354.1

Enzyme Details

2. Short transient receptor potential channel 6

General function:: Involved in ion channel activity
Specific function:: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion
Gene Name:: TRPC6
Uniprot ID:: Q9Y210
Molecular weight:: 106325.3

Enzyme Details

3. Short transient receptor potential channel 7

General function:: Involved in ion channel activity
Specific function:: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion
Gene Name:: TRPC7
Uniprot ID:: Q9HCX4
Molecular weight:: 99561.3

Only showing the first 10 proteins. There are 148 proteins in total.

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Showing Compound Card for DG(18:0/16:0/0:0) (CDB000876)

Structure for CDB000876 (DG(18:0/16:0/0:0))

Enzymes

Transporters