| Identification |
|---|
| HMDB Protein ID
| CDBP02521 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sn1-specific diacylglycerol lipase alpha |
| Description
| Not Available |
| Synonyms
|
- DGL-alpha
- Neural stem cell-derived dendrite regulator
|
| Gene Name
| DAGLA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in triglyceride lipase activity |
| Specific Function
| Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| triglyceride lipase activity |
| carboxylesterase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q12.2 |
| SNPs
| DAGLA |
| Gene Sequence
|
>3129 bp
ATGCCCGGGATCGTGGTGTTCCGGCGGCGCTGGTCTGTGGGCAGTGATGACCTCGTCCTA
CCGGCCATCTTCCTCTTTCTCCTGCATACCACCTGGTTTGTGATCCTGTCCGTGGTGCTC
TTCGGCCTGGTCTATAACCCGCACGAGGCCTGCTCCCTGAACCTGGTGGACCACGGCCGC
GGCTACCTGGGCATCCTGCTGAGCTGCATGATCGCTGAGATGGCCATCATCTGGCTGAGC
ATGCGCGGGGGCATCCTCTACACGGAGCCCCGTGACTCCATGCAGTACGTGCTCTACGTG
CGCCTGGCCATCCTGGTGATCGAGTTCATCTACGCCATCGTGGGCATCGTCTGGCTCACT
CAGTACTACACCTCCTGCAACGACCTCACTGCCAAGAATGTCACCCTCGGAATGGTTGTC
TGCAACTGGGTAGTCATCCTCAGTGTGTGCATCACTGTCCTCTGCGTCTTCGACCCCACG
GGCCGCACCTTTGTCAAGCTGAGAGCCACCAAGAGGAGGCAGCGTAACCTGCGGACCTAC
AACCTGCGGCACCGCTTAGAGGAGGGTCAAGCCACCAGCTGGTCGCGCCGGCTCAAAGTG
TTCCTCTGCTGCACGCGGACGAAGGACTCCCAGTCAGATGCCTACTCAGAAATCGCCTAC
CTCTTTGCGGAGTTCTTCCGGGACCTTGACATTGTGCCATCCGACATCATTGCTGGCCTG
GTGCTGCTCCGGCAGCGGCAGCGGGCCAAGCGCAACGCCGTGCTGGACGAGGCAAACAAT
GACATCTTGGCCTTCCTGTCTGGGATGCCGGTGACCAGAAACACCAAGTACCTCGACCTC
AAGAATTCACAAGAGATGCTCCGCTACAAAGAGGTCTGCTACTACATGCTCTTTGCCCTG
GCTGCCTACGGGTGGCCCATGTACCTGATGCGGAAGCCCGCCTGCGGCCTCTGCCAACTG
GCTCGGTCCTGCTCGTGTTGCCTGTGTCCTGCGAGGCCGCGGTTCGCCCCTGGAGTCACC
ATCGAGGAAGACAACTGCTGTGGCTGTAATGCCATTGCCATCCGGCGCCACTTCCTGGAC
GAGAACATGACTGCGGTGGACATCGTCTATACCTCCTGCCATGATGCGGTCTATGAAACG
CCCTTCTACGTGGCGGTGGACCATGACAAGAAGAAAGTGGTGATCAGTATCCGGGGGACC
CTGTCCCCCAAGGATGCCCTGACTGACCTGACGGGTGATGCTGAGCGCCTCCCCGTGGAG
GGGCACCACGGCACCTGGCTGGGCCACAAGGGTATGGTCCTCTCAGCTGAGTACATCAAG
AAGAAACTGGAGCAGGAGATGGTCCTGTCCCAGGCCTTTGGGCGAGACCTGGGCCGCGGA
ACCAAACACTACGGCCTGATTGTGGTGGGCCACTCCCTGGGCGCGGGCACTGCTGCCATC
CTCTCCTTCCTTCTGCGCCCACAGTATCCGACCCTCAAGTGCTTTGCCTACTCCCCGCCA
GGGGGCCTGCTGAGTGAGGATGCGATGGAGTATTCCAAGGAGTTCGTGACTGCTGTGGTT
CTGGGCAAAGACCTCGTCCCCAGGATTGGCCTCTCTCAGCTGGAAGGCTTCCGCAGACAG
CTCCTGGATGTCCTGCAGCGAAGCACCAAGCCCAAATGGCGGATCATCGTGGGGGCCACC
AAATGCATCCCCAAGTCGGAGCTGCCTGAGGAGGTAGAGGTGACCACCCTGGCCAGCACG
CGGCTCTGGACCCACCCCAGCGACCTAACTATAGCCCTCTCAGCCAGCACTCCACTCTAC
CCGCCCGGCCGCATCATCCACGTGGTCCACAACCACCCTGCAGAGCAGTGCTGCTGCTGT
GAGCAGGAGGAGCCCACATACTTTGCCATCTGGGGCGACAACAAGGCCTTCAATGAGGTG
ATCATCTCGCCAGCCATGCTGCATGAGCACCTGCCCTATGTGGTCATGGAGGGGCTCAAC
AAGGTGCTGGAGAACTACAACAAGGGGAAGACCGCTCTGCTCTCTGCAGCCAAGGTCATG
GTGAGCCCTACCGAGGTGGACCTGACTCCTGAGCTCATCTTCCAGCAGCAGCCACTCCCC
ACGGGGCCGCCCATGCCCACTGGCCTTGCCCTGGAGCTGCCGACTGCAGACCACCGCAAC
AGCAGCGTCAGGAGCAAGTCCCAGTCTGAGATGAGCCTGGAGGGCTTCTCGGAGGGGCGG
CTGCTGTCGCCAGTGGTTGCGGCGGCGGCCCGCCAGGACCCGGTGGAGCTGCTGCTGCTG
TCTACCCAGGAGCGGCTGGCGGCGGAGCTGCAGGCCCGGCGGGCACCACTGGCCACCATG
GAGAGCCTCTCGGACACTGAGTCCCTGTACAGCTTCGACTCGCGCCGCTCCTCAGGCTTC
CGCAGCATCCGGGGCTCCCCCAGCCTCCACGCTGTGCTGGAGCGTGATGAAGGCCACCTC
TTCTACATTGACCCTGCCATCCCCGAGGAAAACCCATCCCTGAGCTCGCGCACTGAGCTG
CTGGCGGCCGACAGCCTGTCCAAGCACTCACAGGACACGCAGCCCCTGGAGGCGGCCCTG
GGCAGTGGCGGCGTCACTCCTGAGCGGCCCCCCAGTGCTGCGGCCAATGACGAGGAGGAA
GAGGTTGGCGGTGGGGGTGGCGGGCCGGCCTCCCGCGGGGAGCTGGCGCTGCACAATGGG
CGCCTGGGGGACTCGCCCAGTCCTCAGGTGCTGGAATTCGCCGAGTTCATCGACAGCCTC
TTCAACCTGGACAGCAAGAGCAGCTCCTTCCAAGACCTCTACTGCATGGTGGTGCCCGAG
AGCCCCACCAGTGACTACGCTGAGGGCCCCAAGTCCCCCAGCCAGCAAGAGATCCTGCTC
CGTGCCCAGTTCGAGCCCAACCTGGTGCCCAAGCCCCCACGGCTCTTTGCCGGCTCAGCC
GACCCCTCCTCGGGCATCTCACTCTCGCCCTCCTTCCCGCTCAGCTCCTCGGGTGAGCTC
ATGGACCTGACGCCCACGGGCCTCAGTAGCCAGGAATGCCTGGCGGCTGACAAGATCCGG
ACTTCTACCCCCACTGGCCACGGAGCCAGCCCCGCCAAGCAAGATGAGCTGGTCATCTCA
GCACGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1042 |
| Molecular Weight
| 114950.7 |
| Theoretical pI
| 6.31 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["23-43", "61-81", "102-122", "137-157"]
|
| Protein Sequence
|
>Sn1-specific diacylglycerol lipase alpha
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLY
PPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLN
KVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRN
SSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATM
ESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTEL
LAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNG
RLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILL
RAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIR
TSTPTGHGASPAKQDELVISAR
|
| External Links |
|---|
| GenBank ID Protein
| 27262632 |
| UniProtKB/Swiss-Prot ID
| Q9Y4D2 |
| UniProtKB/Swiss-Prot Entry Name
| DGLA_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_006133.1 |
| GeneCard ID
| DAGLA |
| GenAtlas ID
| DAGLA |
| HGNC ID
| HGNC:1165 |
| References |
|---|
| General References
| Not Available |