| Identification |
|---|
| HMDB Protein ID
| CDBP04930 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tensin-like C1 domain-containing phosphatase |
| Description
| Not Available |
| Synonyms
|
- C1 domain-containing phosphatase and tensin homolog
- C1-TEN
- Tensin-2
|
| Gene Name
| TENC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling pathway |
| Specific Function
| Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling |
| GO Classification
|
| Function |
| binding |
| protein binding |
| Process |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cell junction
- focal adhesion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q13.13 |
| SNPs
| TENC1 |
| Gene Sequence
|
>4230 bp
ATGAAGTCCAGCGGCCCTGTGGAGAGGCTGCTCAGAGCCCTGGGGAGGAGGGACAGCAGC
CGGGCCGCAAGCAGGCCTAGGAAAGCTGAGCCTCATAGCTTCCGGGAGAAGGTTTTCCGG
AAGAAACCTCCAGTCTGTGCAGTATGTAAGGTGACCATCGATGGGACAGGCGTTTCGTGC
AGAGTCTGCAAGGTGGCGACGCACAGAAAATGTGAAGCAAAGGTGACTTCAGCCTGTCAG
GCCTTGCCTCCCGTGGAGTTGCGGCGAAACACGGCCCCAGTCAGGCGCATAGAGCACCTG
GGATCCACCAAATCTCTGAACCACTCAAAGCAGCGCAGCACTCTGCCCAGGAGCTTCAGC
CTGGACCCGCTCATGGAGCGGCGCTGGGACTTAGACCTCACCTACGTGACGGAGCGCATC
TTGGCCGCCGCCTTCCCCGCGCGGCCCGATGAACAGCGGCACCGGGGCCACCTGCGCGAG
CTGGCCCATGTGCTGCAATCCAAGCACCGGGACAAGTACCTGCTCTTCAACCTTTCAGAG
AAAAGGCATGACCTGACCCGCTTAAACCCCAAGGTTCAAGACTTCGGCTGGCCTGAGCTG
CATGCTCCACCCCTGGACAAGCTGTGCTCCATCTGCAAAGCCATGGAGACATGGCTCAGT
GCTGACCCACAGCACGTGGTCGTACTATACTGCAAGGGAAACAAGGGCAAGCTTGGGGTC
ATCGTTTCTGCCTACATGCACTACAGCAAGATCTCTGCAGGGGCGGACCAGGCACTGGCC
ACTCTTACCATGCGGAAATTCTGCGAGGACAAGGTGGCCACAGAACTGCAGCCCTCCCAG
CGTCGATATATCAGCTACTTCAGTGGGCTGCTATCTGGCTCCATCAGAATGAACAGCAGC
CCTCTCTTCCTGCACTATGTGCTCATCCCCATGCTGCCAGCCTTTGAACCTGGCACAGGC
TTCCAGCCCTTCCTTAAAATCTACCAGTCCATGCAGCTTGTCTACACATCTGGAGTCTAT
CACATTGCAGGCCCTGGTCCCCAGCAGCTTTGCATCAGCCTGGAGCCAGCCCTCCTCCTC
AAAGGCGATGTCATGGTAACATGTTATCACAAGGGTGGCCGGGGCACAGACCGGACCCTC
GTGTTCCGAGTCCAGTTCCACACCTGCACCATCCACGGACCACAGCTCACTTTCCCCAAG
GACCAGCTTGACGAGGCCTGGACTGATGAGAGGTTCCCCTTCCAAGCCTCCGTGGAGTTT
GTCTTCTCCTCCAGCCCCGAGAAGATCAAAGGCAGCACTCCACGGAACGACCCCTCGGTC
TCTGTCGACTACAACACCACTGAGCCAGCCGTGCGCTGGGACTCCTATGAGAACTTCAAC
CAGCACCACGAGGACAGTGTGGATGGCTCCTTGACCCACACCCGGGGTCCCCTGGATGGC
AGTCCTTATGCCCAGGTGCAGCGGCCTCCCCGGCAGACCCCCCCGGCACCCTCTCCAGAG
CCTCCACCACCCCCCATGCTCTCTGTCAGCAGCGACTCAGGCCATTCCTCCACGCTGACC
ACAGAGCCGGCTGCTGAGTCCCCTGGCCGGCCGCCCCCTACAGCTGCTGAACGGCAGGAG
CTGGATCGCCTCCTAGGAGGCTGCGGAGTGGCCAGTGGGGGCCGGGGAGCTGGGCGCGAG
ACGGCCATCCTAGATGACGAAGAGCAGCCCACTGTGGGCGGAGGCCCCCACCTCGGAGTG
TATCCAGGCCATAGGCCTGGCCTCAGCCGCCACTGCTCCTGCCGCCAGGGCTACCGGGAG
CCCTGCGGGGTTCCCAATGGGGGCTACTACCGGCCAGAGGGAACCCTGGAGAGGAGGCGA
CTGGCCTACGGGGGCTATGAGGGATCCCCCCAGGGCTACGCCGAGGCCTCGATGGAGAAG
AGGCGCCTCTGCCGATCGCTGTCAGAGGGGCTATACCCCTACCCACCTGAGATGGGGAAA
CCAGCCACTGGGGACTTTGGCTACCGCGCCCCAGGCTACCGGGAGGTGGTCATCCTGGAG
GACCCTGGGCTGCCTGCCCTATACCCATGCCCAGCCTGCGAGGAGAAGCTGGCGCTGCCT
ACAGCAGCCTTGTATGGACTGCGGCTGGAGAGGGAGGCTGGAGAAGGGTGGGCAAGTGAG
GCTGGCAAGCCTCTCCTGCACCCAGTGCGGCCTGGGCACCCGCTGCCTCTGCTCTTGCCT
GCCTGTGGGCATCACCATGCCCCGATGCCTGACTACAGCTGCCTGAAGCCACCCAAGGCA
GGCGAGGAAGGGCACGAGGGCTGCTCCTACACCATGTGCCCCGAAGGCAGGTATGGGCAT
CCAGGGTACCCTGCCCTGGTGACATACAGCTATGGAGGAGCAGTTCCCAGTTACTGCCCA
GCATATGGCCGTGTGCCTCATAGCTGTGGCTCTCCAGGAGAGGGCAGAGGGTATCCCAGC
CCTGGTGCCCACTCCCCACGGGCTGGCTCCATTTCCCCGGGCAGCCCGCCCTATCCACAA
TCTAGGAAGCTGAGCTACGAGATCCCTACGGAGGAGGGAGGGGACAGGTACCCATTGCCT
GGGCACCTGGCCTCAGCAGGACCTTTGGCATCTGCAGAGTCGCTGGAGCCGGTGTCCTGG
AGGGAGGGCCCCAGTGGGCACAGCACACTGCCTCGGTCTCCCCGAGATGCCCCATGCAGT
GCTTCGTCAGAGTTGTCTGGTCCCTCCACGCCCCTGCACACCAGCAGTCCAGTCCAGGGC
AAGGAAAGCACCCGGCGACAGGACACCAGGTCCCCCACCTCAGCGCCCACTCAGAGACTG
AGTCCTGGCGAGGCCTTGCCCCCTGTTTCCCAGGCAGGCACCGGAAAGGCCCCTGAGCTG
CCGTCGGGAAGTGGGCCTGAGCCTCTGGCCCCTAGCCCAGTCTCTCCGACCTTCCCTCCC
AGCTCGCCCAGTGACTGGCCTCAGGAAAGGAGTCCAGGGGGCCACTCAGATGGCGCCAGT
CCTCGGAGCCCTGTGCCCACCACACTTCCTGGCCTCCGCCACGCCCCCTGGCAAGGCCCT
CGAGGCCCCCCCGACAGCCCAGATGGGTCTCCCCTCACTCCTGTGCCTTCCCAGATGCCC
TGGCTTGTGGCCAGCCCAGAGCCGCCTCAGAGCTCACCTACACCTGCTTTCCCCCTGGCT
GCCTCCTATGACACCAATGGCCTTAGCCAGCCCCCACTTCCTGAGAAACGCCACCTGCCC
GGGCCGGGGCAACAGCCAGGACCCTGGGGCCCAGAGCAGGCATCATCGCCAGCCAGAGGC
ATCAGTCACCATGTCACCTTCGCACCTCTGCTCTCAGATAATGTCCCCCAAACCCCAGAG
CCTCCTACACAAGAGAGCCAAAGCAATGTCAAGTTTGTCCAGGATACATCCAAGTTCTGG
TACAAGCCACACCTGTCCCGTGACCAAGCCATTGCCCTGCTGAAGGACAAGGACCCTGGG
GCCTTCCTGATCAGGGACAGTCATTCATTCCAAGGAGCTTATGGGCTGGCCCTCAAGGTG
GCCACACCGCCACCCAGTGCCCAGCCCTGGAAAGGGGACCCCGTGGAACAGCTGGTCCGC
CATTTCCTCATCGAGACTGGGCCCAAAGGGGTGAAGATCAAGGGCTGCCCCAGTGAGCCC
TACTTTGGCAGCCTGTCCGCCTTGGTCTCCCAGCACTCCATCTCCCCCATCTCCCTGCCC
TGCTGCCTGCGCATTCCCAGCAAAGATCCTCTGGAAGAGACCCCAGAGGCTCCAGTGCCC
ACCAACATGAGCACAGCGGCAGACCTCCTGCGTCAGGGTGCTGCCTGCAGCGTGCTCTAC
TTGACCTCAGTGGAGACAGAGTCACTGACGGGCCCCCAAGCTGTGGCCCGGGCCAGCTCT
GCAGCTCTGAGCTGTAGCCCCCGCCCGACACCAGCTGTTGTCCACTTCAAGGTGTCAGCC
CAGGGCATTACACTGACGGACAACCAAAGGAAGCTCTTCTTTCGCCGCCATTATCCAGTG
AACAGCATCACCTTCTCCAGCACTGACCCTCAAGACCGGAGATGGACCAACCCAGACGGG
ACCACCTCCAAGATCTTTGGTTTCGTGGCCAAGAAGCCGGGAAGCCCCTGGGAGAATGTG
TGTCACCTCTTTGCAGAGCTTGACCCAGATCAGCCTGCTGGCGCCATTGTCACCTTCATC
ACCAAAGTTCTACTGGGCCAGAGAAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1409 |
| Molecular Weight
| 152579.0 |
| Theoretical pI
| 8.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tensin-like C1 domain-containing phosphatase
MKSSGPVERLLRALGRRDSSRAASRPRKAEPHSFREKVFRKKPPVCAVCKVTIDGTGVSC
RVCKVATHRKCEAKVTSACQALPPVELRRNTAPVRRIEHLGSTKSLNHSKQRSTLPRSFS
LDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSE
KRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGV
IVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGSIRMNSS
PLFLHYVLIPMLPAFEPGTGFQPFLKIYQSMQLVYTSGVYHIAGPGPQQLCISLEPALLL
KGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDERFPFQASVEF
VFSSSPEKIKGSTPRNDPSVSVDYNTTEPAVRWDSYENFNQHHEDSVDGSLTHTRGPLDG
SPYAQVQRPPRQTPPAPSPEPPPPPMLSVSSDSGHSSTLTTEPAAESPGRPPPTAAERQE
LDRLLGGCGVASGGRGAGRETAILDDEEQPTVGGGPHLGVYPGHRPGLSRHCSCRQGYRE
PCGVPNGGYYRPEGTLERRRLAYGGYEGSPQGYAEASMEKRRLCRSLSEGLYPYPPEMGK
PATGDFGYRAPGYREVVILEDPGLPALYPCPACEEKLALPTAALYGLRLEREAGEGWASE
AGKPLLHPVRPGHPLPLLLPACGHHHAPMPDYSCLKPPKAGEEGHEGCSYTMCPEGRYGH
PGYPALVTYSYGGAVPSYCPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISPGSPPYPQ
SRKLSYEIPTEEGGDRYPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCS
ASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPEL
PSGSGPEPLAPSPVSPTFPPSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQGP
RGPPDSPDGSPLTPVPSQMPWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLP
GPGQQPGPWGPEQASSPARGISHHVTFAPLLSDNVPQTPEPPTQESQSNVKFVQDTSKFW
YKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVR
HFLIETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETPEAPVP
TNMSTAADLLRQGAACSVLYLTSVETESLTGPQAVARASSAALSCSPRPTPAVVHFKVSA
QGITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTNPDGTTSKIFGFVAKKPGSPWENV
CHLFAELDPDQPAGAIVTFITKVLLGQRK
|
| External Links |
|---|
| GenBank ID Protein
| 38787957 |
| UniProtKB/Swiss-Prot ID
| Q63HR2 |
| UniProtKB/Swiss-Prot Entry Name
| TENC1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_170754.2 |
| GeneCard ID
| TENC1 |
| GenAtlas ID
| TENC1 |
| HGNC ID
| HGNC:19737 |
| References |
|---|
| General References
| Not Available |