| Identification |
|---|
| HMDB Protein ID
| CDBP04929 |
| Secondary Accession Numbers
| Not Available |
| Name
| Kinase suppressor of Ras 2 |
| Description
| Not Available |
| Synonyms
|
- hKSR2
|
| Gene Name
| KSR2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling pathway |
| Specific Function
| Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| protein serine/threonine kinase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
| phosphorylation |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q24.22-q24.23 |
| SNPs
| KSR2 |
| Gene Sequence
|
>2766 bp
ATGATAGACTTGAGCATCTCCAACCTGGAAGGGCTTAGGACCAAATGTGCTACCTCCAAC
GACCTCACACAAAAAGAAATCCGGACCCTGGAGAGCAAGCTGGTGAAGTACTTCAGCCGG
CAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAACGCGGAGCTGGACGGCTTC
CCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAGGAGGTCCTGGAGGAAATC
TCCCCCGGCCAGCTGAGCCTGGAGGACCTCTTGGAGATGACGGATGAACAGGTGTGCGAG
ACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGCCTCAACGCCTCCCTCTCC
TGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAACAAGACTGGACCATCCAG
TGGCCCACGACAGAGACGGGGAAGGAGAACAATCCCGTGTGCCCCCCGGAGCCCACCCCG
TGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCCAAGTGCGTCCAGCACTAT
TGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCACGTGGACAGGCTTACCGTG
GACGCCTACCCGGGCTTGTGCCCGCCCCCGCCACTGGAGTCGGGCCACCGTTCCCTGCCC
CCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGCACCCCCAACATCGTCACC
ACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAACAAGCTGAAGCCCCCGGGG
ACCCCACCGCCCTCCTCCCGAAAACTGATACACTTGATCCCGGGATTCACCGCGCTGCAT
CGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGACGAGGCCCACACGCCCAAA
GCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGCAGCGTAGGCAGCTGCGAG
AACATCCCCTCTCAGCAGCGCTCCCCGCTGCTGTCCGAGCGCTCCCTCCGCTCCTTCTTT
GTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCACACTGAGGCCAACTTCTCT
GCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCTCGCAGAGATCTCGGCAAC
TCCATCAAGCACAGGTTTTCCACCAAGTACTGGATGTCTCAGACGTGCACAGTCTGTGGG
AAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTAAAGTGCCACAACAAATGC
ACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGAGGAGATCCAGCAAGGTTA
GTCCGGACAGAGTCCGTTCCGTGTGACATCAACAACCCTCTACGGAAGCCACCTCGCTAT
TCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAAATCAACAAGGACCACATC
CCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCCACGACGTCCTCCACGCCC
TCCTCGCCAGCACCCCCCCTCCCTCCTAGTGCCACGCCGCCTTCTCCCCTACACCCTTCC
CCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCATCCCACTACTACAAATAC
AAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAGACGCCGACCCGGGCGCCC
CAGGTCATCCTGCATCCGGTGACCTCGAATCCAATCTTGGAAGGAAATCCATTACTTCAA
ATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGATGAGGCCGAAGAGTCAGAG
GATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGGAGCTTCCCACGCAAGGCC
AGCCAGACCAGCATCTTCCTTCAGGAGTGGGACATCCCCTTTGAGCAGCTGGAGATCGGC
GAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGCCGCTGGCATGGCGAGGTG
GCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAGCTCAAGGCCTTCAAGCGG
GAGGTGATGGCCTACAGGCAGACACGGCATGAGAACGTGGTGCTTTTCATGGGTGCCTGC
ATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAGGGACGGACGCTCTATTCC
GTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACCAGGCAGATTGCTCAAGAA
ATTGTGAAGGGCATGGGCTACCTCCACGCCAAGGGAATCCTACACAAGGACCTCAAGTCA
AAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGACTTTGGACTCTTCAGCATT
TCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGCATCCAGAATGGCTGGCTA
TGCCACCTGGCACCAGAGATCATCCGCCAGCTGTCCCCCGACACAGAGGAGGATAAGCTC
CCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATCTGGTATGAACTCCACGCC
AGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATCTGGCAAATGGGCACAGGC
ATGAAACCCAACCTCAGCCAGATTGGCATGGGAAAAGAAATCTCGGACATTCTTCTCTTC
TGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAGCTCATGGACATGCTGGAG
AAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACATTTCTGGAAGTCTGCAGAG
CTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 950 |
| Molecular Weight
| 107631.4 |
| Theoretical pI
| 8.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Kinase suppressor of Ras 2
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
|
| External Links |
|---|
| GenBank ID Protein
| 167621456 |
| UniProtKB/Swiss-Prot ID
| Q6VAB6 |
| UniProtKB/Swiss-Prot Entry Name
| KSR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| KSR2 |
| GenAtlas ID
| KSR2 |
| HGNC ID
| HGNC:18610 |
| References |
|---|
| General References
| Not Available |