Cannabis Compound Database: Showing Protein Kinase suppressor of Ras 2 (CDBP04929)

Identification Biological properties Gene properties Protein properties External links References XML Show 16 compounds

Identification

HMDB Protein ID

CDBP04929

Secondary Accession Numbers

Not Available

Name

Kinase suppressor of Ras 2

Description

Not Available

Synonyms

hKSR2

Gene Name

KSR2

Protein Type

Enzyme

Biological Properties

General Function

Involved in intracellular signaling pathway

Specific Function

Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production

GO Classification

Function
protein serine/threonine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
intracellular signaling pathway
signaling
signaling pathway
phosphorylation

Cellular Location

Cytoplasm
Peripheral membrane protein
Membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

12q24.22-q24.23

SNPs

KSR2

Gene Sequence

>2766 bp
ATGATAGACTTGAGCATCTCCAACCTGGAAGGGCTTAGGACCAAATGTGCTACCTCCAAC
GACCTCACACAAAAAGAAATCCGGACCCTGGAGAGCAAGCTGGTGAAGTACTTCAGCCGG
CAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAACGCGGAGCTGGACGGCTTC
CCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAGGAGGTCCTGGAGGAAATC
TCCCCCGGCCAGCTGAGCCTGGAGGACCTCTTGGAGATGACGGATGAACAGGTGTGCGAG
ACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGCCTCAACGCCTCCCTCTCC
TGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAACAAGACTGGACCATCCAG
TGGCCCACGACAGAGACGGGGAAGGAGAACAATCCCGTGTGCCCCCCGGAGCCCACCCCG
TGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCCAAGTGCGTCCAGCACTAT
TGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCACGTGGACAGGCTTACCGTG
GACGCCTACCCGGGCTTGTGCCCGCCCCCGCCACTGGAGTCGGGCCACCGTTCCCTGCCC
CCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGCACCCCCAACATCGTCACC
ACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAACAAGCTGAAGCCCCCGGGG
ACCCCACCGCCCTCCTCCCGAAAACTGATACACTTGATCCCGGGATTCACCGCGCTGCAT
CGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGACGAGGCCCACACGCCCAAA
GCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGCAGCGTAGGCAGCTGCGAG
AACATCCCCTCTCAGCAGCGCTCCCCGCTGCTGTCCGAGCGCTCCCTCCGCTCCTTCTTT
GTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCACACTGAGGCCAACTTCTCT
GCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCTCGCAGAGATCTCGGCAAC
TCCATCAAGCACAGGTTTTCCACCAAGTACTGGATGTCTCAGACGTGCACAGTCTGTGGG
AAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTAAAGTGCCACAACAAATGC
ACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGAGGAGATCCAGCAAGGTTA
GTCCGGACAGAGTCCGTTCCGTGTGACATCAACAACCCTCTACGGAAGCCACCTCGCTAT
TCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAAATCAACAAGGACCACATC
CCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCCACGACGTCCTCCACGCCC
TCCTCGCCAGCACCCCCCCTCCCTCCTAGTGCCACGCCGCCTTCTCCCCTACACCCTTCC
CCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCATCCCACTACTACAAATAC
AAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAGACGCCGACCCGGGCGCCC
CAGGTCATCCTGCATCCGGTGACCTCGAATCCAATCTTGGAAGGAAATCCATTACTTCAA
ATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGATGAGGCCGAAGAGTCAGAG
GATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGGAGCTTCCCACGCAAGGCC
AGCCAGACCAGCATCTTCCTTCAGGAGTGGGACATCCCCTTTGAGCAGCTGGAGATCGGC
GAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGCCGCTGGCATGGCGAGGTG
GCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAGCTCAAGGCCTTCAAGCGG
GAGGTGATGGCCTACAGGCAGACACGGCATGAGAACGTGGTGCTTTTCATGGGTGCCTGC
ATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAGGGACGGACGCTCTATTCC
GTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACCAGGCAGATTGCTCAAGAA
ATTGTGAAGGGCATGGGCTACCTCCACGCCAAGGGAATCCTACACAAGGACCTCAAGTCA
AAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGACTTTGGACTCTTCAGCATT
TCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGCATCCAGAATGGCTGGCTA
TGCCACCTGGCACCAGAGATCATCCGCCAGCTGTCCCCCGACACAGAGGAGGATAAGCTC
CCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATCTGGTATGAACTCCACGCC
AGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATCTGGCAAATGGGCACAGGC
ATGAAACCCAACCTCAGCCAGATTGGCATGGGAAAAGAAATCTCGGACATTCTTCTCTTC
TGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAGCTCATGGACATGCTGGAG
AAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACATTTCTGGAAGTCTGCAGAG
CTGTGA

Protein Properties

Number of Residues

950

Molecular Weight

107631.4

Theoretical pI

8.87

Pfam Domain Function

Pkinase_Tyr (PF07714 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Kinase suppressor of Ras 2
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL

External Links

GenBank ID Protein

167621456

UniProtKB/Swiss-Prot ID

Q6VAB6

UniProtKB/Swiss-Prot Entry Name

KSR2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

Not Available

GeneCard ID