| Identification |
|---|
| HMDB Protein ID
| CDBP00231 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lipid phosphate phosphohydrolase 1 |
| Description
| Not Available |
| Synonyms
|
- PAP-2a
- PAP2-alpha
- PAP2a
- Phosphatidate phosphohydrolase type 2a
- Phosphatidic acid phosphatase 2a
|
| Gene Name
| PPAP2A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| phospholipid metabolic process |
| regulation of lipid metabolic process |
| sphingolipid biosynthetic process |
| phospholipid dephosphorylation |
| germ cell migration |
| protein kinase C-activating G-protein coupled receptor signaling pathway |
| negative regulation of cell proliferation |
| androgen receptor signaling pathway |
| Cellular Component |
| integral to plasma membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| Molecular Function |
| phosphatidate phosphatase activity |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Fc gamma R-mediated phagocytosis | Not Available |  | | Fat digestion and absorption | Not Available |  | | Phospholipid Biosynthesis |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q11 |
| SNPs
| PPAP2A |
| Gene Sequence
|
>855 bp
ATGTTCGACAAGACGCGGCTGCCGTACGTGGCCCTCGATGTGCTCTGCGTGTTGCTGGCT
GGATTGCCTTTTGCAATTCTTACTTCAAGGCATACCCCCTTCCAACGAGGAGTATTCTGT
AATGATGAGTCCATCAAGTACCCTTACAAAGAAGACACCATACCTTATGCGTTATTAGGT
GGAATAATCATTCCATTCAGTATTATCGTTATTATTCTTGGAGAAACCCTGTCTGTTTAC
TGTAACCTTTTGCACTCAAATTCCTTTATCAGGAATAACTACATAGCCACTATTTACAAA
GCCATTGGAACCTTTTTATTTGGTGCAGCTGCTAGTCAGTCCCTGACTGACATTGCCAAG
TATTCAATAGGCAGACTGCGGCCTCACTTCTTGGATGTTTGTGATCCAGATTGGTCAAAA
ATCAACTGCAGCGATGGTTACATTGAATACTACATATGTCGAGGGAATGCAGAAAGAGTT
AAGGAAGGCAGGTTGTCCTTCTATTCAGGCCACTCTTCGTTTTCCATGTACTGCATGCTG
TTTGTGGCACTTTATCTTCAAGCCAGGATGAAGGGAGACTGGGCAAGACTCTTACGCCCC
ACACTGCAATTTGGTCTTGTTGCCGTATCCATTTATGTGGGCCTTTCTCGAGTTTCTGAT
TATAAACACCACTGGAGCGATGTGTTGACTGGACTCATTCAGGGAGCTCTGGTTGCAATA
TTAGTTGCTGTATATGTATCGGATTTCTTCAAAGAAAGAACTTCTTTTAAAGAAAGAAAA
GAGGAGGACTCTCATACAACTCTGCATGAAACACCAACAACTGGGAATCACTATCCGAGC
AATCACCAGCCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 284 |
| Molecular Weight
| 32155.715 |
| Theoretical pI
| 7.965 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lipid phosphate phosphohydrolase 1
MFDKTRLPYVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDESIKYPYKEDTIPYALLG
GIIIPFSIIVIILGETLSVYCNLLHSNSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAK
YSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCML
FVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAI
LVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP
|
| External Links |
|---|
| GenBank ID Protein
| 2467298 |
| UniProtKB/Swiss-Prot ID
| O14494 |
| UniProtKB/Swiss-Prot Entry Name
| LPP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB000888 |
| GeneCard ID
| PPAP2A |
| GenAtlas ID
| PPAP2A |
| HGNC ID
| HGNC:9228 |
| References |
|---|
| General References
| Not Available |