Identification
HMDB Protein ID CDBP02023
Secondary Accession Numbers Not Available
Name Short transient receptor potential channel 3
Description Not Available
Synonyms
  1. TRP-3
  2. Transient receptor protein 3
  3. TrpC3
  4. hTrp-3
  5. hTrp3
Gene Name TRPC3
Protein Type Receptor
Biological Properties
General Function Involved in ion channel activity
Specific Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion
GO Classification
Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
calcium channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
Process
di-, tri-valent inorganic cation transport
divalent metal ion transport
calcium ion transport
establishment of localization
transport
transmembrane transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q27
SNPs TRPC3
Gene Sequence
>2547 bp
ATGGAGGGAAGCCCATCCCTGAGACGCATGACAGTGATGCGGGAGAAGGGCCGGCGCCAG
GCTGTCAGGGGCCCGGCCTTCATGTTCAATGACCGCGGCACCAGCCTCACCGCCGAGGAG
GAGCGCTTCCTCGACGCCGCCGAGTACGGCAACATCCCAGTGGTGCGCAAGATGCTGGAG
GAGTCCAAGACGCTGAACGTCAACTGCGTGGACTACATGGGCCAGAACGCGCTGCAGCTG
GCTGTGGGCAACGAGCACCTGGAGGTGACCGAGCTGCTGCTCAAGAAGGAGAACCTGGCG
CGCATTGGCGACGCCCTGCTGCTCGCCATCAGCAAGGGCTACGTGCGCATTGTAGAGGCC
ATCCTCAACCACCCTGGCTTCGCGGCCAGCAAGCGTCTCACTCTGAGCCCCTGTGAGCAG
GAGCTGCAGGACGACGACTTCTACGCTTACGATGAGGACGGCACGCGCTTCTCGCCGGAC
ATCACCCCCATCATCCTGGCGGCGCACTGCCAGAAATACGAAGTGGTGCACATGCTGCTG
ATGAAGGGTGCCAGGATCGAGCGGCCGCACGACTATTTCTGCAAGTGCGGGGACTGCATG
GAGAAGCAGAGGCACGACTCCTTCAGCCACTCACGCTCGAGGATCAATGCCTACAAGGGG
CTGGCCAGCCCGGCTTACCTCTCATTGTCCAGCGAGGACCCGGTGCTTACGGCCCTAGAG
CTCAGCAACGAGCTGGCCAAGCTGGCCAACATAGAGAAGGAGTTCAAGAATGACTATCGG
AAGCTCTCCATGCAATGCAAAGACTTTGTAGTGGGTGTGCTGGATCTCTGCCGAGACTCA
GAAGAGGTAGAAGCCATTCTGAATGGAGATCTGGAATCAGCAGAGCCTCTGGAGGTACAC
AGGCACAAAGCTTCATTAAGTCGTGTCAAACTTGCCATTAAGTATGAAGTCAAAAAGTTT
GTGGCTCATCCCAACTGCCAGCAGCAGCTCTTGACGATCTGGTATGAGAACCTCTCAGGC
CTAAGGGAGCAGACCATAGCTATCAAGTGTCTCGTTGTGCTGGTCGTGGCCCTGGGCCTT
CCATTCCTGGCCATTGGCTACTGGATCGCACCTTGCAGCAGGCTGGGGAAAATTCTGCGA
AGCCCTTTTATGAAGTTTGTAGCACATGCAGCTTCTTTCATCATCTTCCTGGGTCTGCTT
GTGTTCAATGCCTCAGACAGGTTCGAAGGCATCACCACGCTGCCCAATATCACAGTTACT
GACTATCCCAAACAGATCTTCAGGGTGAAAACCACCCAGTTTACATGGACTGAAATGCTA
ATTATGGTCTGGGTTCTTGGAATGATGTGGTCTGAATGTAAAGAGCTCTGGCTGGAAGGA
CCTAGGGAATACATTTTGCAGTTGTGGAATGTGCTTGACTTTGGGATGCTGTCCATCTTC
ATTGCTGCTTTCACAGCCAGATTCCTAGCTTTCCTTCAGGCAACGAAGGCACAACAGTAT
GTGGACAGTTACGTCCAAGAGAGTGACCTCAGTGAAGTGACACTCCCACCAGAGATACAG
TATTTCACTTATGCTAGAGATAAATGGCTCCCTTCTGACCCTCAGATTATATCTGAAGGC
CTTTATGCCATAGCTGTTGTGCTCAGCTTCTCTCGGATTGCGTACATCCTCCCTGCAAAT
GAGAGCTTTGGCCCCCTGCAGATCTCTCTTGGAAGGACTGTAAAGGACATATTCAAGTTC
ATGGTCCTCTTTATTATGGTGTTTTTTGCCTTTATGATTGGCATGTTCATACTTTATTCT
TACTACCTTGGGGCTAAAGTTAATGCTGCTTTTACCACTGTAGAAGAAAGTTTCAAGACT
TTATTTTGGTCAATATTTGGGTTGTCTGAAGTGACTTCCGTTGTGCTCAAATATGATCAC
AAATTCATAGAAAATATTGGATACGTTCTTTATGGAATATACAATGTAACTATGGTGGTC
GTTTTACTCAACATGCTAATTGCTATGATTAATAGCTCATATCAAGAAATTGAGGATGAC
AGTGATGTAGAATGGAAGTTTGCTCGTTCAAAACTTTGGTTATCCTATTTTGATGATGGA
AAAACATTACCTCCACCTTTCAGTCTAGTTCCTAGTCCAAAATCATTTGTTTATTTCATC
ATGCGAATTGTTAACTTTCCCAAATGCAGAAGGAGAAGACTTCAGAAGGATATAGAAATG
GGAATGGGTAACTCAAAGTCCAGGTTAAACCTCTTCACTCAGTCTAACTCAAGAGTTTTT
GAATCACACAGTTTTAACAGCATTCTCAATCAGCCAACACGTTATCAGCAGATAATGAAA
AGACTTATAAAGCGGTATGTCTTGAAAGCACAAGTAGACAAAGAAAATGATGAAGTTAAT
GAAGGTGAATTAAAAGAAATCAAGCAAGATATCTCCAGCCTTCGTTATGAACTTTTGGAA
GACAAGAGCCAAGCAACTGAGGAATTAGCCATTCTAATTCATAAACTTAGTGAGAAACTG
AATCCCAGCATGCTGAGATGTGAATGA
Protein Properties
Number of Residues 848
Molecular Weight 97354.1
Theoretical pI 6.74
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["350-370", "382-402", "431-451", "464-484", "536-556", "580-600", "616-636", "650-670", "707-726"]
Protein Sequence
>Short transient receptor potential channel 3
MEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLE
ESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEA
ILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLL
MKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALE
LSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVH
RHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGL
PFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVT
DYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIF
IAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEG
LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYS
YYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVV
VLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFI
MRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMK
RLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKL
NPSMLRCE
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q13507
UniProtKB/Swiss-Prot Entry Name TRPC3_HUMAN
PDB IDs Not Available
GenBank Gene ID U47050
GeneCard ID TRPC3
GenAtlas ID TRPC3
HGNC ID HGNC:12335
References
General References Not Available