| Identification |
|---|
| HMDB Protein ID
| CDBP00304 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lipoprotein lipase |
| Description
| Not Available |
| Synonyms
|
- LPL
|
| Gene Name
| LPL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).
|
| GO Classification
|
| Biological Process |
| positive regulation of macrophage derived foam cell differentiation |
| positive regulation of sequestering of triglyceride |
| response to drug |
| triglyceride homeostasis |
| triglyceride catabolic process |
| fatty acid biosynthetic process |
| triglyceride biosynthetic process |
| phospholipid metabolic process |
| lipoprotein metabolic process |
| very-low-density lipoprotein particle remodeling |
| chylomicron remodeling |
| positive regulation of cholesterol storage |
| Cellular Component |
| cell surface |
| anchored to membrane |
| plasma membrane |
| chylomicron |
| very-low-density lipoprotein particle |
| extracellular space |
| extracellular matrix |
| Function |
| hydrolase activity |
| lipoprotein lipase activity |
| carboxylesterase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| Molecular Function |
| phospholipase activity |
| lipoprotein lipase activity |
| triglyceride binding |
| triglyceride lipase activity |
| heparin binding |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerolipid Metabolism |    |  | | PPAR signaling pathway | Not Available |  | | Alzheimer's disease | Not Available |  | | Glycerol Kinase Deficiency |    | Not Available | | D-glyceric acidura |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p22 |
| SNPs
| LPL |
| Gene Sequence
|
>1428 bp
ATGGAGAGCAAAGCCCTGCTCGTGCTGACTCTGGCCGTGTGGCTCCAGAGTCTGACCGCC
TCCCGCGGAGGGGTGGCCGCCGCCGACCAAAGAAGAGATTTTATCGACATCGAAAGTAAA
TTTGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTA
GCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCAT
GGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTAC
AAGAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCAT
TACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAAC
TGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTT
GGAGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACT
GGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCT
GATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGC
ATTGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAG
CCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTGGAGATGTG
GACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTG
AATGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGG
CTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCAATAAAGTC
AGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTC
TTCCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAG
GCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCATTCACTCTG
CCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGA
GAACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGG
TGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGACTCAGAAA
AAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCG
GTATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 475 |
| Molecular Weight
| 53162.07 |
| Theoretical pI
| 8.145 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lipoprotein lipase
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGV
AESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEH
YPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRIT
GLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQ
PGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKG
LCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQ
AFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDW
WSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
|
| External Links |
|---|
| GenBank ID Protein
| 189065397 |
| UniProtKB/Swiss-Prot ID
| P06858 |
| UniProtKB/Swiss-Prot Entry Name
| LIPL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK312311 |
| GeneCard ID
| LPL |
| GenAtlas ID
| LPL |
| HGNC ID
| HGNC:6677 |
| References |
|---|
| General References
| Not Available |