Showing Protein Lipid phosphate phosphohydrolase 3 (CDBP00236)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 20 compounds
Identification
HMDB Protein ID CDBP00236
Secondary Accession Numbers Not Available
Name Lipid phosphate phosphohydrolase 3
Description Not Available
Synonyms
  1. PAP-2b
  2. PAP2-beta
  3. PAP2b
  4. Phosphatidate phosphohydrolase type 2b
  5. Phosphatidic acid phosphatase 2b
  6. VCIP
  7. Vascular endothelial growth factor and type I collagen-inducible protein
Gene Name PPAP2B
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
GO Classification
Biological Process
sphingolipid biosynthetic process
protein stabilization
germ cell migration
canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion
canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration
canonical Wnt receptor signaling pathway involved in positive regulation of wound healing
gastrulation with mouth forming second
homotypic cell-cell adhesion
negative regulation of protein phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
regulation of Wnt receptor signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
blood vessel development
small molecule metabolic process
phospholipid metabolic process
Cellular Component
adherens junction
integral to membrane
endoplasmic reticulum membrane
plasma membrane
Golgi apparatus
Component
membrane
cell part
Function
catalytic activity
Molecular Function
phosphoprotein phosphatase activity
lipid phosphatase activity
phosphatidate phosphatase activity
Cellular Location
  1. Cell membrane
  2. Golgi apparatus
  3. Multi-pass membrane protein
  4. Multi-pass membrane protein
  5. trans-Golgi network membrane
Pathways
Gene Properties
Chromosome Location 1
Locus 1p32.2
SNPs PPAP2B
Gene Sequence 
>936 bp
ATGCAAAACTACAAGTACGACAAAGCGATCGTCCCGGAGAGCAAGAACGGCGGCAGCCCG
GCGCTCAACAACAACCCGAGGAGGAGCGGCAGCAAGCGGGTGCTGCTCATCTGCCTCGAC
CTCTTCTGCCTCTTCATGGCGGGCCTCCCCTTCCTCATCATCGAGACAAGCACCATCAAG
CCTTACCACCGAGGGTTTTACTGCAATGATGAGAGCATCAAGTACCCACTGAAAACTGGT
GAGACAATAAATGACGCTGTGCTCTGTGCCGTGGGGATCGTCATTGCCATCCTCGCGATC
ATCACGGGGGAATTCTACCGGATCTATTACCTGAAGAAGTCGCGGTCGACGATTCAGAAC
CCCTACGTGGCAGCACTCTATAAGCAAGTGGGCTGCTTCCTCTTTGGCTGTGCCATCAGC
CAGTCTTTCACAGACATTGCCAAAGTGTCCATAGGGCGCCTGCGTCCTCACTTCTTGAGT
GTCTGCAACCCTGATTTCAGCCAGATCAACTGCTCTGAAGGCTACATTCAGAACTACAGA
TGCAGAGGTGATGACAGCAAAGTCCAGGAAGCCAGGAAGTCCTTCTTCTCTGGCCATGCC
TCCTTCTCCATGTACACTATGCTGTATTTGGTGCTATACCTGCAGGCCCGCTTCACTTGG
CGAGGAGCCCGCCTGCTCCGGCCCCTCCTGCAGTTCACCTTGATCATGATGGCCTTCTAC
ACGGGACTGTCTCGCGTATCAGACCACAAGCACCATCCCAGTGATGTTCTGGCAGGATTT
GCTCAAGGAGCCCTGGTGGCCTGCTGCATAGTTTTCTTCGTGTCTGACCTCTTCAAGACT
AAGACGACGCTCTCCCTGCCTGCCCCTGCTATCCGGAAGGAAATCCTTTCACCTGTGGAC
ATTATTGACAGGAACAATCACCACAACATGATGTAG
Protein Properties
Number of Residues 311
Molecular Weight 35115.61
Theoretical pI 9.149
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Lipid phosphate phosphohydrolase 3
MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIK
PYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKKSRSTIQN
PYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYR
CRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFY
TGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVD
IIDRNNHHNMM
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O14495
UniProtKB/Swiss-Prot Entry Name LPP3_HUMAN
PDB IDs Not Available
GenBank Gene ID AB000889
GeneCard ID PPAP2B
GenAtlas ID PPAP2B
HGNC ID HGNC:9229
References
General References Not Available