| Identification |
|---|
| HMDB Protein ID
| CDBP04944 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho GTPase-activating protein 29 |
| Description
| Not Available |
| Synonyms
|
- PTPL1-associated RhoGAP protein 1
- Rho-type GTPase-activating protein 29
|
| Gene Name
| ARHGAP29 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling pathway |
| Specific Function
| GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p22.1 |
| SNPs
| ARHGAP29 |
| Gene Sequence
|
>3786 bp
ATGATTGCTCACAAACAGAAAAAGACAAAGAAAAAACGTGCTTGGGCATCAGGTCAACTC
TCTACTGATATTACAACTTCTGAAATGGGGCTCAAGTCCTTAAGTTCCAACTCTATTTTT
GATCCGGATTACATCAAGGAGTTGGTGAATGATATCAGGAAGTTCTCCCACATGTTACTA
TATTTGAAAGAAGCCATATTTTCAGACTGTTTTAAAGAAGTTATTCATATACGTCTAGAG
GAACTGCTCCGTGTTTTAAAGTCTATAATGAATAAACATCAGAACCTCAATTCTGTTGAT
CTTCAAAATGCTGCAGAAATGCTCACTGCAAAAGTGAAAGCTGTGAACTTCACAGAAGTT
AATGAAGAAAACAAAAACGATCTCTTCCAGGAAGTGTTTTCTTCTATTGAAACTTTGGCA
TTTACCTTTGGAAATATCCTTACAAACTTCCTTATGGGAGATGTAGGCAATGATTCATTA
TTGCGACTGCCTGTTTCTCGAGAAACTAAGTCGTTTGAAAATGTTTCTGTGGAATCAGTG
GACTCATCCAGTGAAAAAGGAAATTTTTCCCCTTTAGAACTAGACAACGTGCTGTTAAAG
AACACTGACTCTATCGAGCTGGCTTTGTCATATGCTAAAACTTGGTCAAAATATACTAAG
AACATAGTTTCATGGGTTGAAAAAAAGCTTAACTTGGAATTGGAGTCCACTAGAAATATG
GTCAAGTTGGCAGAGGCAACTAGAACTAACATTGGAATTCAGGAGTTCATGCCACTGCAG
TCTCTGTTTACTAATGCTCTTCTTAATGATATAGAAAGCAGTCACCTTTTACAACAAACA
ATTGCAGCTCTCCAGGCTAACAAATTTGTGCAGCCTCTACTTGGAAGGAAAAATGAAATG
GAAAAACAAAGGAAAGAAATAAAAGAGCTTTGGAAACAGGAGCAAAATAAAATGCTTGAA
GCAGAGAATGCTCTCAAAAAGGCAAAATTATTATGCATGCAACGTCAAGATGAATATGAG
AAAGCAAAGTCTTCCATGTTTCGTGCAGAAGAGGAGCATCTGTCTTCAAGTGGCGGATTA
GCAAAAAATCTCAACAAGCAACTAGAAAAAAAGCGAAGGTTGGAAGAGGAGGCTCTCCAA
AAAGTAGAAGAAGCAAATGAACTTTACAAAGTTTGTGTGACAAATGTTGAAGAAAGAAGA
AATGATCTAGAAAATACCAAAAGAGAAATTTTAGCACAACTCCGGACACTTGTTTTCCAG
TGTGATCTTACCCTTAAAGCTGTAACAGTTAACCTCTTCCACATGCAGCATCTGCAGGCT
GCTTCCCTTGCAGACAGTTTACAGTCTCTCTGTGATAGTGCCAAACTCTATGACCCAGGC
CAAGAGTACAGTGAATTTGTCAAGGCCACAAATTCAACTGAAGAAGAAAAAGTTGATGGA
AATGTAAATAAACATTTAAATAGTTCCCAACCTTCAGGATTTGGACCTGCCAACTCTTTA
GAGGATGTTGTACGCCTTCCTGACAGTTCTAATAAAATTGAAGAGGACAGATGCTCTAAC
AGTGCAGATATAACAGGTCCTTCCTTTATAAGATCATGGACATTTGGGATGTTTAGTGAT
TCTGAGAGCACTGGAGGGAGCAGCGAATCTAGATCTCTGGATTCAGAATCTATAAGTCCA
GGAGACTTTCATCGAAAACTTCCACGAACACCATCCAGTGGAACTATGTCCTCTGCAGAT
GATCTAGATGAAAGAGAGCCACCTTCCCCTTCAGAAACTGGACCCAATTCCCTTGGAACA
TTTAAGAAAACATTGATGTCAAAGGCAGCTCTCACACACAAGTTTCGCAAATTGAGATCC
CCCACGAAATGTAGGGATTGTGAAGGCATTGTAGTGTTCCAAGGTGTTGAATGTGAAGAG
TGTCTCCTTGTTTGTCATCGAAAGTGTTTGGAAAATTTAGTCATTATTTGTGGTCATCAG
AAACTTCCAGGAAAAATACACTTATTTGGAGCAGAATTCACACAAGTTGCAAAAAAGGAA
CCAGATGGTATCCCTTTTATACTCAAAATATGTGCCTCAGAGATTGAAAATAGAGCTTTG
TGTCTACAGGGAATTTATCGTGTGTGTGGAAACAAAATAAAAACTGAAAAATTGTGTCAA
GCTTTGGAAAATGGAATGCACTTGGTAGATATTTCAGAATTTAGTTCACATGATATCTGT
GACGTCTTGAAATTATACCTTCGGCAGCTCCCAGAACCATTTATTTTATTTCGATTGTAC
AAGGAATTTATAGACCTTGCAAAAGAGATCCAACATGTAAATGAAGAACAAGAGACAAAA
AAGAATAGTCTTGAAGACAAAAAATGGCCAAATATGTGTATAGAAATAAACCGAATTCTT
CTAAAAAGCAAAGACCTTCTAAGACAATTGCCAGCATCAAATTTTAACAGTCTTCATTTC
CTTATAGTACATCTAAAGCGGGTAGTAGATCATGCAGAAGAAAACAAGATGAACTCCAAA
AACTTGGGGGTGATATTTGGACCAAGTCTCATTAGGCCAAGGCCCACAACTGCTCCTATC
ACCATCTCCTCCCTTGCAGAGTATTCAAATCAAGCACGCTTGGTAGAGTTTCTCATTACT
TACTCACAGAAGATCTTCGATGGGTCCCTACAACCACAAGATGTTATGTGTAGCATAGGT
GTTGTTGATCAAGGCTGTTTTCCAAAGCCTCTGTTATCACCAGAAGAAAGAGACATTGAA
CGTTCCATGAAGTCACTATTTTTTTCTTCAAAGGAAGATATCCATACTTCAGAGAGTGAA
AGCAAAATTTTTGAACGAGCTACATCATTTGAGGAATCAGAACGCAAGCAAAATGCGTTA
GGAAAATGTGATGCATGTCTCAGTGACAAAGCACAGTTGCTTCTAGACCAAGAGGCTGAA
TCAGCATCCCAAAAGATAGAAGATGGTAAAACCCCTAAGCCACTTTCTCTGAAATCTGAT
AGGTCAACAAACAATGTGGAGAGGCATACTCCAAGGACCAAGATTAGACCTGTAAGTTTG
CCTGTAGATAGACTACTTCTTGCAAGTCCTCCTAATGAGAGAAATGGCAGAAATATGGGA
AATGTAAATTTAGACAAGTTTTGCAAGAATCCTGCCTTTGAAGGAGTTAATAGAAAAGAC
GCTGCTACTACTGTTTGTTCCAAATTTAATGGCTTTGACCAGCAAACTCTACAGAAAATT
CAGGACAAACAGTATGAACAAAACAGCCTAACTGCCAAGACTACAATGATCATGCCCAGT
GCACTCCAGGAAAAAGGAGTGACAACAAGCCTCCAGATTAGTGGGGACCATTCTATCAAT
GCCACTCAACCCAGTAAGCCATATGCAGAGCCAGTCAGGTCAGTGAGAGAGGCATCTGAG
AGACGGTCTTCAGATTCCTACCCTCTCGCTCCTGTCAGAGCACCCAGAACACTGCAGCCT
CAACATTGGACAACATTTTATAAACCACATGCTCCCATCATCAGTATCAGGGGGAATGAG
GAGAAGCCAGCTTCACCCTCAGCAGCAGTGCCTCCTGGCACAGATCACGATCCCCACGGT
CTCGTGGTGAAGTCAATGCCAGACCCAGACAAAGCATCAGCTTGTCCTGGGCAAGCAACT
GGTCAACCTAAAGAAGACTCTGAGGAGCTTGGCTTGCCTGATGTGAATCCAATGTGTCAG
AGACCAAGGCTAAAACGAATGCAACAGTTTGAAGACCTCGAAGGTGAAATTCCACAATTT
GTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1261 |
| Molecular Weight
| 142062.2 |
| Theoretical pI
| 6.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho GTPase-activating protein 29
MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
V
|
| External Links |
|---|
| GenBank ID Protein
| 134304853 |
| UniProtKB/Swiss-Prot ID
| Q52LW3 |
| UniProtKB/Swiss-Prot Entry Name
| RHG29_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004815.3 |
| GeneCard ID
| ARHGAP29 |
| GenAtlas ID
| ARHGAP29 |
| HGNC ID
| HGNC:30207 |
| References |
|---|
| General References
| Not Available |