Identification |
HMDB Protein ID
| CDBP00225 |
Secondary Accession Numbers
| Not Available |
Name
| Lipid phosphate phosphohydrolase 2 |
Description
| Not Available |
Synonyms
|
- PAP-2c
- PAP2-G
- PAP2-gamma
- PAP2c
- Phosphatidate phosphohydrolase type 2c
- Phosphatidic acid phosphatase 2c
|
Gene Name
| PPAP2C |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
|
GO Classification
|
Biological Process |
small molecule metabolic process |
phospholipid metabolic process |
sphingolipid biosynthetic process |
Cellular Component |
plasma membrane |
integral to membrane |
Component |
membrane |
cell part |
Function |
catalytic activity |
Molecular Function |
phosphoprotein phosphatase activity |
phosphatidate phosphatase activity |
|
Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glycerophospholipid metabolism | Not Available | | Ether lipid metabolism | Not Available | | Fc gamma R-mediated phagocytosis | Not Available | | Fat digestion and absorption | Not Available | | Glycerolipid Metabolism | | |
|
Gene Properties |
Chromosome Location
| 19 |
Locus
| 19p13 |
SNPs
| PPAP2C |
Gene Sequence
|
>867 bp
ATGCAGCGGAGGTGGGTCTTCGTGCTGCTCGACGTGCTGTGCTTACTGGTCGCCTCCCTG
CCCTTCGCTATCCTGACGCTGGTGAACGCCCCGTACAAGCGAGGATTTTACTGCGGGGAT
GACTCCATCCGGTACCCCTACCGTCCAGATACCATCACCCACGGGCTCATGGCTGGGGTC
ACCATCACGGCCACCGTCATCCTTGTCTCGGCCGGGGAAGCCTACCTGGTGTACACAGAC
CGGCTCTATTCTCGCTCGGACTTCAACAACTACGTGGCTGCTGTATACAAGGTGCTGGGG
ACCTTCCTGTTTGGGGCTGCCGTGAGCCAGTCTCTGACAGACCTGGCCAAGTACATGATT
GGGCGTCTGAGGCCCAACTTCCTAGCCGTCTGCGACCCCGACTGGAGCCGGGTCAACTGC
TCGGTCTATGTGCAGCTGGAGAAGGTGTGCAGGGGAAACCCTGCTGATGTCACCGAGGCC
AGGTTGTCTTTCTACTCGGGACACTCTTCCTTTGGGATGTACTGCATGGTGTTCTTGGCG
CTGTATGTGCAGGCACGACTCTGTTGGAAGTGGGCACGGCTGCTGCGACCCACAGTCCAG
TTCTTCCTGGTGGCCTTTGCCCTCTACGTGGGCTACACCCGCGTGTCTGATTACAAACAC
CACTGGAGCGATGTCCTTGTTGGCCTCCTGCAGGGGGCACTGGTGGCTGCCCTCACTGTC
TGCTACATCTCAGACTTCTTCAAAGCCCGACCCCCACAGCACTGTCTGAAGGAGGAGGAG
CTGGAACGGAAGCCCAGCCTGTCACTGACGTTGACCCTGGGCGAGGCTGACCACAACCAC
TATGGATACCCGCACTCCTCCTCCTGA
|
Protein Properties |
Number of Residues
| 288 |
Molecular Weight
| 32573.435 |
Theoretical pI
| 8.357 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Lipid phosphate phosphohydrolase 2
MQRRWVFVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGV
TITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMI
GRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFLA
LYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTV
CYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEADHNHYGYPHSSS
|
External Links |
GenBank ID Protein
| 4505977 |
UniProtKB/Swiss-Prot ID
| O43688 |
UniProtKB/Swiss-Prot Entry Name
| LPP2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_003712.2 |
GeneCard ID
| PPAP2C |
GenAtlas ID
| PPAP2C |
HGNC ID
| HGNC:9230 |
References |
General References
| Not Available |