Cannabis Compound Database: Showing Compound Card for Ethanol (CDB006141)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (14)transporters (37) Show 105 proteins XML

Record Information

Version

1.0

Created at

2020-03-18 23:21:31 UTC

Updated at

2020-12-07 19:06:54 UTC

CannabisDB ID

CDB006141

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Ethanol

Description

Ethanol, also known as ethyl alcohol or alcohol, belongs to the class of organic compounds known as primary alcohols. Primary alcohols are compounds having a primary alcohol functional group, with the general structure RCOH (R=alkyl, aryl). Ethanol is a clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. Indeed, ethanol has widespread use as a solvent of substances intended for human contact or consumption, including scents, flavorings, colorings, and medicines. Ethanol has a depressive effect on the central nervous system and because of its psychoactive effects, it is considered a drug. Ethanol has a complex mode of action and affects multiple systems in the brain, most notably it acts as an agonist to the GABA receptors. Death from ethanol consumption is possible when blood alcohol level reaches 0.4%. A blood level of 0.5% or more is commonly fatal. Levels of even less than 0.1% can cause intoxication, with unconsciousness often occurring at 0.3-0.4 %. Ethanol is metabolized by the body as an energy-providing carbohydrate nutrient, as it metabolizes into acetyl CoA, an intermediate common with glucose metabolism, that can be used for energy in the citric acid cycle or for biosynthesis. Ethanol within the human body is converted into acetaldehyde by alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. The product of the first step of this breakdown, acetaldehyde, is more toxic than ethanol. Acetaldehyde is linked to most of the adverse clinical effects of alcohol. Ethanol has been shown to increase the risk of developing cirrhosis of the liver, multiple forms of cancer, and alcoholism. Industrially, ethanol is produced both as a petrochemical, through the hydration of ethylene, and biologically, by fermenting sugars with yeast. Small amounts of ethanol are endogenously produced by gut microflora through anaerobic fermentation. However, most ethanol detected in biofluids and tissues likely comes from consumption of alcoholic beverages. Absolute ethanol or anhydrous alcohol generally refers to purified ethanol, containing no more than one percent water. Absolute alcohol is not intended for human consumption. It often contains trace amounts of toxic benzene (used to remove water by azeotropic distillation). Consumption of this form of ethanol can be fatal over a short time period. Generally absolute or pure ethanol is used as a solvent for lab and industrial settings where water will disrupt a desired reaction. Pure ethanol is classed as 200 proof in the USA and Canada, equivalent to 175 degrees proof in the UK system. Ethanol is a general biomarker for the consumption of alcohol. Ethanol is also a metabolite of Hansenula and Saccharomyces (PMID: 14613880 ).

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
1-Hydroxyethane	ChEBI
[CH2Me(OH)]	ChEBI
[OEtH]	ChEBI
Alcohol	ChEBI
Alcohol etilico	ChEBI
Alcool ethylique	ChEBI
Alkohol	ChEBI
Aethanol	ChEBI
Aethylalkohol	ChEBI
C2H5OH	ChEBI
Dehydrated ethanol	ChEBI
Etanol	ChEBI
Ethyl alcohol	ChEBI
EtOH	ChEBI
Hydroxyethane	ChEBI
Methylcarbinol	ChEBI
Spiritus vini	ChEBI
Anhydrous ethanol	Kegg
Absolute alcohol	HMDB
Absolute ethanol	HMDB
Absolute ethyl alcohol	HMDB
Alcare hand degermer	HMDB
Alcohols	HMDB
Alcool etilico	HMDB
Algrain	HMDB
Alkoholu etylowego	HMDB
Anhydrol	HMDB
Anhydrous alcohol	HMDB
Cologne spirit	HMDB
Cologne spirits	HMDB
Dehydrated alcohol	HMDB
Denatured alcohol	HMDB
Denatured ethanol	HMDB
Desinfektol el	HMDB
Diluted alcohol	HMDB
Distilled spirits	HMDB
Ethanol 200 proof	HMDB
Ethanol solution	HMDB
Ethicap	HMDB
Ethyl alc	HMDB
Ethyl alcohol anhydrous	HMDB
Ethyl alcohol in alcoholic beverages	HMDB
Ethyl alcohol usp	HMDB
Ethyl hydrate	HMDB
Ethyl hydroxide	HMDB
Fermentation alcohol	HMDB
Grain alcohol	HMDB
Hinetoless	HMDB
Infinity pure	HMDB
Jaysol	HMDB
Jaysol S	HMDB
Lux	HMDB
Molasses alcohol	HMDB
Potato alcohol	HMDB
Punctilious ethyl alcohol	HMDB
Pyro	HMDB
Silent spirit	HMDB
Spirit	HMDB
Spirits OF wine	HMDB
Spirt	HMDB
Synasol	HMDB
Tecsol	HMDB
Tecsol C	HMDB
Thanol	HMDB
Undenatured ethanol	HMDB
Alcohol, absolute	HMDB
Alcohol, ethyl	HMDB
Alcohol, grain	HMDB

Chemical Formula

C₂H₆O

Average Molecular Weight

46.07

Monoisotopic Molecular Weight

46.0419

IUPAC Name

ethanol

Traditional Name

ethyl alcohol

CAS Registry Number

64-17-5

SMILES

CCO

InChI Identifier

InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3

InChI Key

LFQSCWFLJHTTHZ-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as primary alcohols. Primary alcohols are compounds comprising the primary alcohol functional group, with the general structure RCOH (R=alkyl, aryl).

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Alcohols and polyols

Direct Parent

Primary alcohols

Alternative Parents

Hydrocarbon derivatives

Substituents

Hydrocarbon derivative
Primary alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

primary alcohol (CHEBI:16236 )
alkyl alcohol (CHEBI:16236 )
ethanols (CHEBI:16236 )
a primary alcohol (ETOH )
a short-chain alcohol (ETOH )

Ontology

Physiological effect

Health effect:

Health condition:

Gastrointestinal disorders:

Psychiatric disorders:

Depression

Cancer:

Lung cancer

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Synthetic:

Personal care product

Biological:

Microbe:

Hansenula:

Hansenula polymorpha

Plant:

Biological location:

Role

Indirect biological role:

Industrial application:

Personal care products

Food and nutrition:

Flavoring agent

Household products:

Antimicrobial agent:

Pharmaceutical industry:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	-114.1 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	1000 mg/mL	Not Available
logP	-0.31	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-0.4	ALOGPS
logP	-0.16	ChemAxon
logS	1.1	ALOGPS
pKa (Strongest Acidic)	16.47	ChemAxon
pKa (Strongest Basic)	-2.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	13.01 m³·mol⁻¹	ChemAxon
Polarizability	5.3 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-003s-9000000000-dabf5a61c5a7da9fbe13	2014-09-20	View Spectrum
GC-MS	Ethanol, non-derivatized, GC-MS Spectrum	splash10-001j-9000000000-a705823ce4aeba7f89e1	Spectrum
GC-MS	Ethanol, non-derivatized, GC-MS Spectrum	splash10-001j-9000000000-a705823ce4aeba7f89e1	Spectrum
Predicted GC-MS	Ethanol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-002b-9000000000-7fa80a491183c1cdd23e	Spectrum
Predicted GC-MS	Ethanol, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0fmi-9200000000-587cc3c48ab7fbf9cd3a	Spectrum
Predicted GC-MS	Ethanol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Ethanol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Ethanol, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI RMU-7M) , Positive	splash10-001j-9000000000-a705823ce4aeba7f89e1	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0002-9000000000-d75d9996bc68c673f090	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0002-9000000000-893c2599624722912f25	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-004i-9000000000-8af4124822065023744f	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-9000000000-22231ed69c5f28bfed79	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0002-9000000000-d2881505c47bbef13f18	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0002-9000000000-2ed988bb761ac20ba44a	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0002-9000000000-5c5e98353b75870c1c55	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0002-9000000000-326f4f38d260a85ea469	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-002b-9000000000-f850ab2a079485c4a276	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-9000000000-b6602db69e5662ad67a9	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0002-9000000000-b6602db69e5662ad67a9	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0002-9000000000-4d0d1c69f8440a7fda18	2021-09-24	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 90 MHz, CDCl₃, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 25.16 MHz, CDCl₃, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Ethanol Degradation		Not Available
Disulfiram Action Pathway		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Sulfotransferase family cytosolic 2B member 1	SULT2B1	19q13.3	O00204	details
UDP-glucuronosyltransferase 1-1	UGT1A1	2q37	P22309	details
Alcohol dehydrogenase [NADP(+)]	AKR1A1	1p33-p32	P14550	details
Alcohol dehydrogenase 4	ADH4	4q22	P08319	details
Alcohol dehydrogenase class-3	ADH5	4q23	P11766	details
Alcohol dehydrogenase 1B	ADH1B	4q23	P00325	details
Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	4q23-q24	P40394	details
Alcohol dehydrogenase 1A	ADH1A	4q23	P07327	details
Alcohol dehydrogenase 6	ADH6	4q23	P28332	details
Alcohol dehydrogenase 1C	ADH1C	4q23	P00326	details
Vascular cell adhesion protein 1	VCAM1	1p32-p31	P19320	details
Glutamate receptor 1	GRIA1	5q33\|5q31.1	P42261	details
5-hydroxytryptamine receptor 3A	HTR3A	11q23.1	P46098	details
Equilibrative nucleoside transporter 2	SLC29A2	11q13	Q14542	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	3p14.3	Q01668	details
Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	12p13.3	Q13936	details
Equilibrative nucleoside transporter 1	SLC29A1	6p21.1	Q99808	details
Glutamate receptor 1	GRIA1	5q33\|5q31.1	P42261	details
5-hydroxytryptamine receptor 3A	HTR3A	11q23.1	P46098	details
Equilibrative nucleoside transporter 2	SLC29A2	11q13	Q14542	details
Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	11p15.5	Q9GZZ6	details
Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	4p14	Q9UGM1	details
Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	1q32	Q13698	details
Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	17q21-q22	Q02641	details
Voltage-dependent calcium channel gamma-1 subunit	CACNG1	17q24	Q06432	details
Voltage-dependent calcium channel gamma-2 subunit	CACNG2	22q13.1	Q9Y698	details
Glutamate receptor 2	GRIA2	4q32-q33	P42262	details
Glutamate [NMDA] receptor subunit 3A	GRIN3A	9q31.1	Q8TCU5	details
Gamma-aminobutyric acid receptor subunit alpha-1	GABRA1	5q34-q35	P14867	details
Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	4p12	P47869	details
Gamma-aminobutyric acid receptor subunit alpha-3	GABRA3		P34903	details
Gamma-aminobutyric acid receptor subunit alpha-4	GABRA4	4p12	P48169	details
Gamma-aminobutyric acid receptor subunit alpha-5	GABRA5	15q11.2-q12	P31644	details
Gamma-aminobutyric acid receptor subunit alpha-6	GABRA6	5q34	Q16445	details
Gamma-aminobutyric acid receptor subunit beta-1	GABRB1	4p12	P18505	details
Gamma-aminobutyric acid receptor subunit beta-2	GABRB2	5q34	P47870	details
Gamma-aminobutyric acid receptor subunit beta-3	GABRB3	15q11.2-q12	P28472	details
Gamma-aminobutyric acid receptor subunit delta	GABRD	1p\|1p36.3	O14764	details
Gamma-aminobutyric acid receptor subunit epsilon	GABRE		P78334	details
Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	4p12	Q8N1C3	details
Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	15q12	Q99928	details
Gamma-aminobutyric acid receptor subunit pi	GABRP	5q33-q34	O00591	details
Gamma-aminobutyric acid receptor subunit theta	GABRQ		Q9UN88	details
Glycine receptor subunit alpha-1	GLRA1	5q32	P23415	details
Glycine receptor subunit alpha-2	GLRA2		P23416	details
G protein-activated inward rectifier potassium channel 1	KCNJ3	2q24.1	P48549	details
G protein-activated inward rectifier potassium channel 4	KCNJ5	11q24	P48544	details
G protein-activated inward rectifier potassium channel 2	KCNJ6	21q22.1\|21q22.1	P48051	details
G protein-activated inward rectifier potassium channel 3	KCNJ9	1q23.2	Q92806	details
Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	8p21	Q15822	details
5-hydroxytryptamine receptor 3B	HTR3B	11q23.1	O95264	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Cytochrome P450 4A11	CYP4A11	1p33	Q02928	details
Alcohol dehydrogenase 4	ADH4	4q22	P08319	details
Alcohol dehydrogenase class-3	ADH5	4q23	P11766	details
Alcohol dehydrogenase 1B	ADH1B	4q23	P00325	details
Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	4q23-q24	P40394	details
Alcohol dehydrogenase 1A	ADH1A	4q23	P07327	details
Alcohol dehydrogenase 6	ADH6	4q23	P28332	details
Alcohol dehydrogenase 1C	ADH1C	4q23	P00326	details
Cytochrome P450 3A4	CYP3A4	7q21.1	P08684	details
Cytochrome P450 2C9	CYP2C9	10q24	P11712	details
Cytochrome P450 2C19	CYP2C19	10q24	P33261	details
Cytochrome P450 2E1	CYP2E1	10q24.3-qter	P05181	details
Cytochrome P450 2B6	CYP2B6	19q13.2	P20813	details
Cytochrome P450 1A1	CYP1A1	15q24.1	P04798	details
Cytochrome P450 1A2	CYP1A2	15q24.1	P05177	details
Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	3p14.3	Q01668	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	4q23-q24	P40394	details
Glutamate receptor 1	GRIA1	5q33\|5q31.1	P42261	details
Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	11p15.5	Q9GZZ6	details
Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	4p14	Q9UGM1	details
Glutamate receptor 2	GRIA2	4q32-q33	P42262	details
Glutamate [NMDA] receptor subunit 3A	GRIN3A	9q31.1	Q8TCU5	details
Gamma-aminobutyric acid receptor subunit alpha-1	GABRA1	5q34-q35	P14867	details
Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	4p12	P47869	details
Gamma-aminobutyric acid receptor subunit alpha-3	GABRA3		P34903	details
Gamma-aminobutyric acid receptor subunit alpha-4	GABRA4	4p12	P48169	details
Gamma-aminobutyric acid receptor subunit alpha-5	GABRA5	15q11.2-q12	P31644	details
Gamma-aminobutyric acid receptor subunit alpha-6	GABRA6	5q34	Q16445	details
Gamma-aminobutyric acid receptor subunit beta-1	GABRB1	4p12	P18505	details
Gamma-aminobutyric acid receptor subunit beta-2	GABRB2	5q34	P47870	details
Gamma-aminobutyric acid receptor subunit beta-3	GABRB3	15q11.2-q12	P28472	details
Gamma-aminobutyric acid receptor subunit delta	GABRD	1p\|1p36.3	O14764	details
Gamma-aminobutyric acid receptor subunit epsilon	GABRE		P78334	details
Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	4p12	Q8N1C3	details
Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	15q12	Q99928	details
Gamma-aminobutyric acid receptor subunit pi	GABRP	5q33-q34	O00591	details
Gamma-aminobutyric acid receptor subunit theta	GABRQ		Q9UN88	details
Glycine receptor subunit alpha-1	GLRA1	5q32	P23415	details
Glycine receptor subunit alpha-2	GLRA2		P23416	details
Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	8p21	Q15822	details
5-hydroxytryptamine receptor 3B	HTR3B	11q23.1	O95264	details
Neuronal acetylcholine receptor subunit beta-2	CHRNB2	1q21.3	P17787	details
Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	15q24	P30532	details
Neuronal acetylcholine receptor subunit beta-4	CHRNB4	15q24	P30926	details
Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	15q24	P32297	details
Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	15q14	P36544	details
Glutamate receptor 3	GRIA3	Xq25-q26	P42263	details
Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	20q13.2-q13.3	P43681	details
Glutamate receptor 4	GRIA4	11q22	P48058	details
Neuronal acetylcholine receptor subunit beta-3	CHRNB3	8p11.2	Q05901	details
Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	8p11.21	Q15825	details
5-hydroxytryptamine receptor 3D	HTR3D		Q70Z44	details
5-hydroxytryptamine receptor 3C	HTR3C		Q8WXA8	details
5-Hydroxytryptamine receptor 3E	HTR3E		A5X5Y0	details

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000108

DrugBank ID

DB00898

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

16236

References

General References

Ryabova OB, Chmil OM, Sibirny AA: Xylose and cellobiose fermentation to ethanol by the thermotolerant methylotrophic yeast Hansenula polymorpha. FEMS Yeast Res. 2003 Nov;4(2):157-64. doi: 10.1016/S1567-1356(03)00146-6. [PubMed:14613880 ]

Only showing the first 10 proteins. There are 105 proteins in total.

Show All

Enzymes

Enzyme Details

1. Sulfotransferase family cytosolic 2B member 1

General function:: Involved in sulfotransferase activity
Specific function:: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
Gene Name:: SULT2B1
Uniprot ID:: O00204
Molecular weight:: 39598.595

Enzyme Details

2. UDP-glucuronosyltransferase 1-1

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:: UGT1A1
Uniprot ID:: P22309
Molecular weight:: 59590.91

Enzyme Details

3. Alcohol dehydrogenase [NADP(+)]

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Gene Name:: AKR1A1
Uniprot ID:: P14550
Molecular weight:: 36572.71

Enzyme Details

4. Alcohol dehydrogenase 4

General function:: Involved in zinc ion binding
Specific function:: Not Available
Gene Name:: ADH4
Uniprot ID:: P08319
Molecular weight:: 40221.335

Enzyme Details

5. Alcohol dehydrogenase class-3

General function:: Involved in zinc ion binding
Specific function:: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
Gene Name:: ADH5
Uniprot ID:: P11766
Molecular weight:: 39723.945

Enzyme Details

6. Alcohol dehydrogenase 1B

General function:: Involved in zinc ion binding
Specific function:: Not Available
Gene Name:: ADH1B
Uniprot ID:: P00325
Molecular weight:: 39835.17

Enzyme Details

7. Alcohol dehydrogenase class 4 mu/sigma chain

General function:: Involved in zinc ion binding
Specific function:: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
Gene Name:: ADH7
Uniprot ID:: P40394
Molecular weight:: 41480.985

Enzyme Details

8. Alcohol dehydrogenase 1A

General function:: Involved in zinc ion binding
Specific function:: Not Available
Gene Name:: ADH1A
Uniprot ID:: P07327
Molecular weight:: 39858.37

Enzyme Details

9. Alcohol dehydrogenase 6

General function:: Involved in zinc ion binding
Specific function:: Not Available
Gene Name:: ADH6
Uniprot ID:: P28332
Molecular weight:: 39072.275

Enzyme Details

10. Alcohol dehydrogenase 1C

General function:: Involved in zinc ion binding
Specific function:: Not Available
Gene Name:: ADH1C
Uniprot ID:: P00326
Molecular weight:: 39867.27

Transporters

Enzyme Details

1. Voltage-dependent L-type calcium channel subunit alpha-1D

General function:: Involved in ion channel activity
Specific function:: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)
Gene Name:: CACNA1D
Uniprot ID:: Q01668
Molecular weight:: 245138.8

Enzyme Details

2. Voltage-dependent L-type calcium channel subunit alpha-1C

General function:: Involved in ion channel activity
Specific function:: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function
Gene Name:: CACNA1C
Uniprot ID:: Q13936
Molecular weight:: 248974.1

Enzyme Details

3. Equilibrative nucleoside transporter 1

General function:: Involved in nucleoside transmembrane transporter activity
Specific function:: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs)
Gene Name:: SLC29A1
Uniprot ID:: Q99808
Molecular weight:: 50218.8

Enzyme Details

4. Glutamate receptor 1

General function:: Involved in ionotropic glutamate receptor activity
Specific function:: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist
Gene Name:: GRIA1
Uniprot ID:: P42261
Molecular weight:: 101505.2

Enzyme Details

5. 5-hydroxytryptamine receptor 3A

General function:: Involved in extracellular ligand-gated ion channel activity
Specific function:: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel
Gene Name:: HTR3A
Uniprot ID:: P46098
Molecular weight:: 55279.8

Enzyme Details

6. Equilibrative nucleoside transporter 2

General function:: Involved in nucleoside transmembrane transporter activity
Specific function:: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine
Gene Name:: SLC29A2
Uniprot ID:: Q14542
Molecular weight:: 50112.3

Enzyme Details

7. Neuronal acetylcholine receptor subunit alpha-10

General function:: Involved in extracellular ligand-gated ion channel activity
Specific function:: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma
Gene Name:: CHRNA10
Uniprot ID:: Q9GZZ6
Molecular weight:: 49704.3

Enzyme Details

8. Neuronal acetylcholine receptor subunit alpha-9

General function:: Involved in extracellular ligand-gated ion channel activity
Specific function:: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion
Gene Name:: CHRNA9
Uniprot ID:: Q9UGM1
Molecular weight:: 54806.6

Enzyme Details

9. Voltage-dependent L-type calcium channel subunit alpha-1S

General function:: Involved in ion channel activity
Specific function:: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle
Gene Name:: CACNA1S
Uniprot ID:: Q13698
Molecular weight:: 212348.1

Enzyme Details

10. Voltage-dependent L-type calcium channel subunit beta-1

General function:: Involved in voltage-gated calcium channel activity
Specific function:: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting
Gene Name:: CACNB1
Uniprot ID:: Q02641
Molecular weight:: 65713.0

Only showing the first 10 proteins. There are 105 proteins in total.

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Showing Compound Card for Ethanol (CDB006141)

Structure for CDB006141 (Ethanol)

Enzymes

Transporters