Cannabis Compound Database: Showing Protein Sulfotransferase family cytosolic 2B member 1 (CDBP00348)

Identification Biological properties Gene properties Protein properties External links References XML Show 13 compounds

Identification

HMDB Protein ID

CDBP00348

Secondary Accession Numbers

Not Available

Name

Sulfotransferase family cytosolic 2B member 1

Description

Not Available

Synonyms

Alcohol sulfotransferase
Hydroxysteroid sulfotransferase 2
ST2B1
Sulfotransferase 2B1

Gene Name

SULT2B1

Protein Type

Enzyme

Biological Properties

General Function

Involved in sulfotransferase activity

Specific Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.

GO Classification

Biological Process
steroid metabolic process
xenobiotic metabolic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
sulfate assimilation
Cellular Component
endoplasmic reticulum
nucleus
cytosol
Function
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity
Molecular Function
steroid sulfotransferase activity
alcohol sulfotransferase activity

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Steroid hormone biosynthesis	Not Available
sulfur metabolism	Not Available
Androgen and Estrogen Metabolism
17-Beta Hydroxysteroid Dehydrogenase III Deficiency		Not Available
Aromatase deficiency		Not Available

Gene Properties

Chromosome Location

Locus

19q13.3

SNPs

SULT2B1

Gene Sequence

>1098 bp
ATGGACGGGCCCGCCGAGCCCCAGATCCCGGGCTTGTGGGACACCTATGAAGATGACATC
TCGGAAATCAGCCAGAAGTTGCCAGGTGAATACTTCCGGTACAAGGGCGTCCCCTTCCCC
GTCGGCCTGTACTCGCTCGAGAGCATCAGCTTGGCGGAGAACACCCAAGATGTGCGGGAC
GACGACATCTTTATCATCACCTACCCCAAGTCAGGCACGACCTGGATGATCGAGATCATC
TGCTTAATCCTGAAGGAAGGGGATCCATCCTGGATCCGCTCCGTGCCCATCTGGGAGCGG
GCACCCTGGTGTGAGACCATTGTGGGTGCCTTCAGCCTCCCGGACCAGTACAGCCCCCGC
CTCATGAGCTCCCATCTTCCCATCCAGATCTTCACCAAGGCCTTCTTCAGCTCCAAGGCC
AAGGTGATCTACATGGGCCGCAACCCCCGGGACGTTGTGGTCTCCCTCTATCATTACTCC
AAGATCGCCGGGCAGTTAAAGGACCCGGGCACACCCGACCAGTTCCTGAGGGACTTCCTC
AAAGGCGAAGTGCAGTTTGGCTCCTGGTTCGACCACATTAAGGGCTGGCTTCGGATGAAG
GGCAAAGACAACTTCCTATTTATCACCTACGAGGAGCTGCAGCAGGACTTACAGGGCTCC
GTGGAGCGCATCTGTGGGTTCCTGGGCCGTCCGCTGGGCAAGGAGGCACTGGGCTCCGTC
GTGGCACACTCAACCTTCAGCGCCATGAAGGCCAACACCATGTCCAACTACACGCTGCTG
CCTCCCAGCCTGCTGGACCACCGTCGCGGGGCCTTCCTCCGGAAAGGGGTCTGCGGCGAC
TGGAAGAACCACTTCACGGTGGCCCAGAGCGAAGCCTTCGATCGTGCCTACCGCAAGCAG
ATGCGGGGGATGCCGACCTTCCCCTGGGATGAAGACCCGGAGGAGGACGGCAGCCCAGAT
CCTGAGCCCAGCCCTGAGCCTGAGCCCAAGCCCAGCCTTGAGCCCAACACCAGCCTGGAG
CGTGAGCCCAGACCCAACTCCAGCCCCAGCCCCAGCCCCGGCCAGGCCTCTGAGACCCCG
CACCCACGACCCTCATAA

Protein Properties

Number of Residues

365

Molecular Weight

39598.595

Theoretical pI

6.547

Pfam Domain Function

Sulfotransfer_1 (PF00685 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Sulfotransferase family cytosolic 2B member 1
MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRD
DDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPR
LMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFL
KGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSV
VAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQ
MRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETP
HPRPS

External Links

GenBank ID Protein

31563386

UniProtKB/Swiss-Prot ID

O00204

UniProtKB/Swiss-Prot Entry Name

ST2B1_HUMAN

PDB IDs