Identification |
HMDB Protein ID
| CDBP03412 |
Secondary Accession Numbers
| Not Available |
Name
| Gamma-aminobutyric acid receptor subunit alpha-1 |
Description
| Not Available |
Synonyms
|
- GABA(A) receptor subunit alpha-1
|
Gene Name
| GABRA1 |
Protein Type
| Receptor |
Biological Properties |
General Function
| Involved in ion transport |
Specific Function
| GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel |
GO Classification
|
Component |
membrane |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
postsynaptic membrane |
Function |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
molecular transducer activity |
signal transducer activity |
gaba receptor activity |
gaba-a receptor activity |
transporter activity |
ion channel activity |
ligand-gated ion channel activity |
extracellular ligand-gated ion channel activity |
receptor activity |
transmembrane receptor activity |
transmembrane transporter activity |
Process |
cell surface receptor linked signaling pathway |
anion transport |
g-protein coupled receptor protein signaling pathway |
inorganic anion transport |
ion transport |
establishment of localization |
transport |
gamma-aminobutyric acid signaling pathway |
chloride transport |
signaling |
signaling pathway |
|
Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Cell junction
- synapse
- postsynaptic cell membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:5 |
Locus
| 5q34-q35 |
SNPs
| GABRA1 |
Gene Sequence
|
>1371 bp
ATGAGGAAAAGTCCAGGTCTGTCTGACTGTCTTTGGGCCTGGATCCTCCTTCTGAGCACA
CTGACTGGAAGAAGCTATGGACAGCCGTCATTACAAGATGAACTTAAAGACAATACCACT
GTCTTCACCAGGATTTTGGACAGACTCCTAGATGGCTATGACAATCGCCTGAGACCAGGA
TTGGGAGAGCGTGTAACCGAAGTGAAGACTGATATCTTCGTCACCAGTTTCGGACCCGTT
TCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAA
AGGTTAAAATTTAAAGGACCTATGACAGTCCTCCGGTTAAATAACCTAATGGCAAGTAAA
ATCCGGACTCCGGACACATTTTTCCACAATGGAAAGAAGTCAGTGGCCCACAACATGACC
ATGCCCAACAAACTCCTGCGGATCACAGAGGATGGCACCTTGCTGTACACCATGAGGCTG
ACAGTGAGAGCTGAATGTCCGATGCATTTGGAGGACTTCCCTATGGATGCCCATGCTTGC
CCACTAAAATTTGGAAGTTATGCTTATACAAGAGCAGAAGTTGTTTATGAATGGACCAGA
GAGCCAGCACGCTCAGTGGTTGTAGCAGAAGATGGATCACGTCTAAACCAGTATGACCTT
CTTGGACAAACAGTAGACTCTGGAATTGTCCAGTCAAGTACAGGAGAATATGTTGTTATG
ACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCA
TGCATAATGACAGTGATTCTCTCACAAGTCTCCTTCTGGCTCAACAGAGAGTCTGTACCA
GCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACATTGAGCATCAGTGCC
AGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCCGTGTGC
TATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACTAAGAGA
GGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCT
CTTATTAAGAAAAACAACACTTACGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCC
AGGGGCGACCCGGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCTAAAGAGGTC
AAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGAC
CGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCT
ACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAG
|
Protein Properties |
Number of Residues
| 456 |
Molecular Weight
| 51801.4 |
Theoretical pI
| 9.61 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["252-273", "279-300", "313-334", "422-443"]
|
Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit alpha-1
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
|
External Links |
GenBank ID Protein
| 31633 |
UniProtKB/Swiss-Prot ID
| P14867 |
UniProtKB/Swiss-Prot Entry Name
| GBRA1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| X14766 |
GeneCard ID
| GABRA1 |
GenAtlas ID
| GABRA1 |
HGNC ID
| HGNC:4075 |
References |
General References
| Not Available |